S. Kumar

Negative DNA supercoiling makes protein-mediated looping deterministic and ergodic within the bacterial doubling time

The paper shows that negative DNA supercoiling reduces stochasticity in protein-mediated DNA looping, making it deterministic and ergodic within bacterial doubling time.

Assessment of immunogenicity and protective efficacy of ZyCoV-D DNA vaccine candidates in Rhesus macaques against SARS-CoV-2 infection

This study evaluates two doses of ZyCoV-D DNA vaccine in rhesus macaques, finding that the 2mg dose via Needle Free Injection System provides better immune response and protection against SARS-CoV-2.

Immunogenic Potential of DNA Vaccine candidate, ZyCoV-D against SARS-CoV-2 in Animal Models

This study evaluates the immunogenic potential of the DNA vaccine ZyCoV-D against SARS-CoV-2 in animal models, showing antibody and Th-1 responses.

Effect of landscape heterogeneity on diurnal raptor community richness and diversity in Jammu Shiwaliks, Jammu and Kashmir

This study assesses diurnal raptor richness and diversity across different land uses in Jammu Shiwaliks, finding higher abundance in farmlands and lower diversity overall.

Systemic inflammation recruits fast-acting anti-inflammatory innate myeloid progenitors from BM into lymphatics

The paper shows that systemic inflammation triggers rapid migration of specific myeloid progenitors from bone marrow to lymphatics via Ccl19/Ccr7, promoting anti-inflammatory responses and replenishment of lymph node dendritic cells.

Osa-miR820 regulatory node primes rice plants to tolerate salt stress in an agronomically advantageous manner

This study identifies Osa-miR820 as a regulator of OsDRM2 that enhances salt stress tolerance in rice with agronomic benefits.

Molecular mechanisms underlying attenuation of live attenuated Japanese encephalitis virus vaccine SA14-14-2

This paper identifies molecular mechanisms of attenuation in the SA14-14-2 Japanese encephalitis vaccine strain, showing loss of NS1 and envelope protein folding defects lead to enhanced immune responses.

Immunogenicity and protective efficacy of a highly thermotolerant, trimeric SARS-CoV-2 receptor binding domain derivative

This study designs a thermotolerant trimeric RBD vaccine candidate that elicits strong neutralizing antibodies against multiple SARS-CoV-2 variants in animal models.

Global transcriptome analysis of Stenotrophomonas maltophilia in response to growth at human body temperature

This study identifies temperature-regulated genes in Stenotrophomonas maltophilia using transcriptome analysis, revealing adaptations for human body temperature.

RNA-protein interaction analysis of SARS-CoV-2 5'- and 3'-untranslated regions identifies an antiviral role of lysosome-associated membrane protein-2

This study identifies host proteins interacting with SARS-CoV-2 5' and 3' UTRs, revealing Lamp2a's antiviral role by reducing viral RNA levels.

Multistability and consequent phenotypic plasticity in AMPK-Akt double negative feedback loop in cancer cells

The paper develops a mathematical model of the AMPK-Akt feedback loop, showing it can generate multistability and phenotypic switching in cancer cells, supported by experimental and clinical data.

Plasma neutralizing antibodies in an infant with interclade HIV-1 superinfection preferentially neutralize superinfecting HIV-1 strains

This study examines nAb responses in an infant with interclade HIV-1 superinfection, finding that neutralizing antibodies primarily target the superinfecting strain and depend on glycans.

Cross-neutralization of SARS-CoV-2 by HIV-1 specific broadly neutralizing antibodies and polyclonal plasma

This study shows that HIV-1 broadly neutralizing antibodies and plasma from HIV-1 infected children can cross-neutralize SARS-CoV-2 by targeting conserved epitopes and glycans on the spike protein.

Neutralizing antibodies induced by first-generation gp41-stabilized HIV-1 envelope trimers and nanoparticles

This study isolates HIV-1 neutralizing antibodies from mice and rabbits immunized with gp41-stabilized trimers and nanoparticles, showing they target different epitopes and elicit Env-dependent breadth.

N6-methyladenosine modification of HIV-1 RNA evades RIG-I-mediated sensing to suppresses type-I interferon induction in monocytic cells

This study shows that HIV-1 RNA's m6A modifications suppress type-I interferon induction in monocytic cells by evading RIG-I sensing.

Using Community Science to Reveal the Global Chemogeography of River Metabolomes

This study uses community science to analyze global river metabolomes, revealing differences between surface water and sediment and significant spatial variation in sediment metabolites.

Relevance of SARS-CoV-2 related factors ACE2 and TMPRSS2 expressions in gastrointestinal tissue with pathogenesis of digestive symptoms, diabetes-associated mortality, and disease recurrence in COVID-19 patients

This study examines ACE2 and TMPRSS2 expression in gastrointestinal tissues to understand their role in digestive symptoms, diabetes mortality, and disease recurrence in COVID-19.

Conditional targeting of phosphatidylserine decarboxylase to lipid droplets

This study identifies a second form of phosphatidylserine decarboxylase, PISD-LD, which localizes to lipid droplets and is regulated by nutritional state, revealing its role in neutral lipid storage.

Structural basis of inhibition of a putative drug efflux transporter NorC, through a single-domain camelid antibody

The paper reports the X-ray structure of NorC, a drug efflux transporter, in complex with a camelid antibody that inhibits its function by stabilizing it in an outward-open conformation.

Vectorchip: Microfluidic platform for highly parallel bite by bite profiling of mosquito-borne pathogen transmission

Vectorchip enables high-throughput analysis of individual mosquito bites to study pathogen transmission dynamics and infectious viral particles.

Codon usage pattern reveals SARS-CoV-2 as a monomorphic pathogen of hybrid origin with role of silent mutations in rapid evolutionary success

The paper analyzes codon usage patterns in SARS-CoV-2 to suggest a single transmission event from a codon-optimized virus and hints at hybrid origins and the role of silent mutations in its evolution.

Isolation and characterization of lumpy skin disease virus from cattle in India

This study isolates and characterizes Lumpy Skin Disease Virus (LSDV) from cattle in India, showing it is closely related to Kenyan strains and demonstrating alternative cell lines for virus isolation and propagation.

BANCOVID, the first D614G variant mRNA-based vaccine candidate against SARS-CoV-2 elicits neutralizing antibody and balanced cellular immune response

This paper develops and characterizes an mRNA-LNP vaccine candidate targeting the D614G variant of SARS-CoV-2, showing neutralizing antibody and balanced cellular immune responses in preclinical trials.

An evolutionary portrait of the progenitor SARS-CoV-2 and its dominant offshoots in COVID-19 pandemic

The paper reconstructs the progenitor SARS-CoV-2 genome and traces its evolution and spread globally, showing multiple dominant strains and lineage replacements in different regions.

The new kid on the block: A dominant-negative mutation of phototropin1 enhances carotenoid content in tomato fruits

A dominant-negative mutation in phototropin1 increases carotenoid content and alters metabolite and protein profiles in tomato fruits.

Exploring the binding of resveratrol to an oncogene promoter DNA sequence d(CCAATTGG)2 through multispectroscopic, nuclear magnetic resonance and molecular dynamics studies

This study investigates resveratrol's binding to an oncogene promoter DNA sequence using spectroscopic and molecular dynamics methods, revealing it binds to the minor groove near AT basepairs.

The deacylase SIRT5 supports melanoma viability by regulating chromatin dynamics

This study identifies SIRT5 as essential for melanoma cell survival and tumor formation, showing it regulates chromatin dynamics and gene expression through histone modifications.

Characterization of neutralizing versus binding antibodies and memory B cells in COVID-19 recovered individuals from India

This study examines humoral and memory B cell responses in Indian COVID-19 recovered individuals, finding that RBD-specific IgG correlates with neutralizing antibodies and can serve as a surrogate for neutralization assays.

Quantification of iPSC-derived vascular networks in novel phototunable angiogenic hydrogels

This paper develops a tunable hydrogel for iPSC-derived vascular network formation and shows that stiffness modulation affects vascular growth.

Structural control of fibrin bioactivity by mechanical deformation

This study shows that mechanical deformation of fibrin induces structural changes that affect its biochemistry and platelet interactions, revealing a mechano-chemical feedback loop.