metabolomics

Chronic Social Isolation Reshapes the Metabolome in Drosophila

This study identifies a distinct metabolomic signature in Drosophila under chronic social isolation, linking it to changes in sleep, feeding, and metabolism.

Characterization of central carbon metabolism of Acinetobacter sp. Tol 5 based on 13C-metabolic flux analysis

This study characterizes central carbon metabolism in Acinetobacter sp. Tol 5 using 13C-MFA, revealing flux patterns under different carbon sources and metabolic pathways.

Effects of different shading levels on growth, physiology and leaf surface micromorphology of Sorbus sibirica "Dong Hong" seedlings

This study evaluates how different shading levels affect growth, physiology, and leaf structure of Sorbus sibirica seedlings, finding that 30% shade promotes growth and chlorophyll content while inhibiting 70% shade.

Sugarcane's drought memory legacy: how past stress shapes future resilience

This study shows that recurrent drought in sugarcane creates a stress memory that enhances future resilience through metabolic changes and improved physiological responses.

Growth phase-dependent priming of galactose metabolism in Escherichia coli

This study shows that prior growth phase in Escherichia coli influences its metabolic response to galactose, revealing a history-dependent behavior regulated by GalR and GalS.

Age-Related Differences in Carbohydrate and Fat Oxidation Over 24 Hours and During Daily Activities in Humans

This study compares carbohydrate and fat oxidation in young and older adults over 24 hours and during daily activities, finding older adults oxidize more fat and less carbohydrate.

Histomonas meleagridis infection and vaccination protection in chickens -- a metabolomics study

This study uses metabolomics to show that H. meleagridis infection disrupts the cecal host-microbiota metabolic interface, with cloacal vaccination offering better metabolic protection than oral vaccination.

Blood Biochemical Responses to Acute Exercise: Findings from the Molecular Transducers of Physical Activity Consortium (MoTrPAC)

The paper identifies shared and distinct biochemical responses to different exercise modes through plasma proteomics, metabolomics, and transcriptomics in sedentary humans.

Odor-based real-time detection of pests on maize plant

This study evaluates odor-based pest detection in maize using sensors and mass spectrometry, showing promising results with mass spectrometry under field conditions.

Comparison of Extraction Methods for the Quantification of Phytohormones from Tomato Fruits and Leaves by LC-MS/MS

The paper compares three phytohormone extraction methods in tomato tissues, finding that solid-phase extraction methods do not consistently outperform a simpler single-phase method in reducing matrix effects.

Multiomics dissection of the CO2-dependent fast growth of Picochlorum celeri

This study profiles multi-omics data in Picochlorum celeri under CO2 limitation, revealing a CO2-dependent switch in Rubisco subunits and extensive post-translational modifications.

COMPARATIVE PHENOMICS IN Limnospira platensis STRAINS REVEALS PHOTOBIOENERGETIC SIMILARITIES AND DIFFERENCES IN AMERICAN AND AFRICAN STRAINS

This study compares phenotypic differences in Limnospira platensis strains from America and Africa under controlled and fluctuating light conditions, revealing variations in growth and light stress response mechanisms.

Microbial metabolite p-cresol associates with constipation in adults with high-functioning autism spectrum disorder and induces constipation-like symptoms in mice

This study links elevated serum p-cresol levels to constipation in adults with high-functioning autism spectrum disorder and shows p-cresol induces constipation-like symptoms in mice.

Fitting dynamics is not identifying causal edges: a white-box masked ODE benchmark for trans-omics digital twins of drug action mechanisms

The paper evaluates the ability of ODE models to infer causal relationships from time-series omics data using a synthetic benchmark based on real biological data.

Targeted Quantitative Analysis of Polar and Phosphorylated Intermediates of Algal and Plant Primary Carbon Metabolism Using an Optimized HILIC-Amide Tandem MS Workflow

The paper develops an optimized targeted metabolomics workflow for analyzing central carbon metabolism intermediates in algae and plants with high sensitivity and accuracy.

Plasma Extracellular Vesicle Lipidomics Reveals an SMPD1-Driven Sphingomyelin Salvage Pathway Collapse in Parkinson's Disease

The paper identifies SMPD1-driven disruption of the ceramide-sphingomyelin axis in Parkinson's disease using plasma extracellular vesicle lipidomics and validates findings across multiple models.

Integrative holo-omic data analysis predicts interactions across the host-microbiome axis

The paper integrates holo-omic data from porcine hosts and gut microbiomes to predict host-microbiome interactions, identifying both known and novel relationships.

Combined Loss of VHL and TSC1 Drives Clear Cell Renal Cell Carcinoma with Metabolic and Redox Reprogramming that Creates an NRF2 Dependency

This study creates a mouse model of VHL-/-TSC1-/- ccRCC, identifies metabolic and redox reprogramming, and highlights NRF2 as a therapeutic target.

Enabling subcellular DESI-MSI for broad adoption: Acquisition, analysis, and application

This paper demonstrates subcellular mass spectrometry imaging using standard hardware and open-source software, enabling accessible spatial metabolomics with subcellular resolution.

MCT6 is an intestinal Lac-Phe exporter required for metformin-associated weight loss

This study identifies MCT6 as an intestinal exporter of Lac-Phe, showing its role in metformin-induced weight loss and systemic metabolite regulation.

Mechanosignaling Promotes Macrophage Apoptosis Resistance in Pulmonary Fibrosis via Metabolic Reprogramming

This study shows that mechanical stiffness in fibrotic lungs promotes macrophage apoptosis resistance through metabolic reprogramming, contributing to fibrosis progression.

Deciphering temporal antifungal dynamics of a rare actinomycete via integrated omics

This study integrates genomic, transcriptomic, and metabolomic analyses to reveal temporally coordinated biosynthetic programs in the rare actinomycete Saccharomonospora xinjiangensis XJ-54 that produce antifungal compounds.

A plasma metabolomics workflow for breast cancer detection using quantitative GC/MS and machine learning

This study develops a plasma metabolomics workflow for breast cancer detection using GC/MS and machine learning, achieving high accuracy in distinguishing breast cancer from healthy controls.

Viral infection and virophage co-infection induce distinct remodeling of host lipidome

This study investigates how giant virus and virophage co-infection alter the host lipidome, finding distinct lipid remodeling patterns associated with each infection type.

Glutamine and GLS1 are key metabolic checkpoints that Limit T cell Infiltration and Function in HNSCC

This study identifies glutamine metabolism as a key mechanism limiting T cell infiltration and function in HNSCC, showing that targeting glutaminase-1 enhances immune response.

Multiomic Profiling Links RDH12-Dependent Retinaldehyde Detoxification to Membrane Remodeling and Ferroptosis

Cereblon Promotes Influenza Virus Replication through AMPK Ubiquitination

This paper identifies cereblon (CRBN) as a host factor that promotes influenza virus replication by degrading AMPK, shifting cellular metabolism to support viral growth.

Gut microbial phenylalanine metabolism contributes to MASLD in a dietary protein-dependent manner

The paper shows dietary protein affects gut microbial phenylalanine metabolism, which contributes to MASLD, and identifies PAGln as a harmful metabolite.

A single bout of mistimed eating is sufficient to cause lasting disruptions in the daily rhythms of metabolism and behavior.

A single bout of mistimed eating disrupts metabolic and behavioral rhythms for several days in mice.

Trustworthy super-resolution reconstruction across spatial omics modalities

This paper introduces spEnhance, a computational framework that improves spatial resolution and reliability of spot-level spatial omics data across multiple modalities.