metabolomics

Metabolomics identifies endocannabinoid system remodeling during obesity associated inflammation in adipose tissue

The paper uses metabolomics to identify endocannabinoid system changes in adipose tissue during obesity-induced inflammation in mice.

Magnetically guided macrophage immunobots coordinate iron-metabolic cascades and immunogenic ferroptosis for tumor immunotherapy

This paper develops magnetically guided macrophage-based immunobots that induce ferroptosis and reprogram the tumor microenvironment to enhance immunotherapy in solid tumors.

Integration of the DD-genome reshapes gene transcription, chromatin architecture and metabolome of allohexaploid wheat leading to enhanced adaptability

This study investigates how integrating the DD genome into tetraploid wheat enhances its adaptability by altering gene transcription, chromatin structure, and metabolome.

Rapid and largely reversible shifts in the canine fecal metabolome during dietary change

The paper examines how the canine fecal metabolome shifts during dietary changes and recovers when the diet is reverted, finding rapid and largely reversible changes with individual variation.

Treatment-Resilient Lipid Remodeling Defines Temozolomide Resistance and Failure of Simvastatin Sensitization in Glioblastoma

This paper identifies treatment-resilient lipid remodeling in TMZ-resistant glioblastoma cells, showing that resistance is linked to coordinated changes in multiple lipid families rather than single species.

Anoxygenic phototrophic Chlorobi use broad metabolic and resource acquisition strategies to support stable near-clonal blooms

This study investigates the formation and persistence of a near-clonal green sulfur bacteria bloom using multi-omics approaches, revealing metabolic strategies that support high cell density and environmental stability.

Systematic mass-spectrometry-guided metabolic fingerprinting elucidates diversity of specialized metabolites across the Brassicaceae

The paper uses mass-spectrometry to systematically profile specialized metabolites across Brassicaceae species, identifying unique profiles and substructure motifs.

A severely affected MRL/Lpr mouse exhibits a divergent clinical-immune profile associated with a profound metabolic alteration.

The paper describes a severely affected MRL/Lpr mouse with divergent clinical-immune features and profound metabolic alterations, highlighting metabolic dysregulation as a key factor in advanced disease.

MetaCarto: biologically faithful automatic layout for genome-scale metabolic maps

MetaCarto automatically generates readable genome-scale metabolic maps by organizing reactions into biologically meaningful layouts, matching curated pathway representations and producing 2621 maps for 108 BiGG models.

Suspension culture drives metabolic rewiring in human pluripotent stem cells

This study compares 2D and 3D suspension cultures of human pluripotent stem cells, finding metabolic rewiring in 3D cultures with increased glycolysis and altered TCA cycle carbon partitioning.

Transcriptional coupling of metabolism and cell mechanics controls humanneuroepithelium morphogenesis

The paper identifies PAX3's role in coupling metabolism and cell mechanics during neuroepithelial morphogenesis, showing mannose metabolism is critical for adherens junction function.

Bittersweet dynamics from flowers to fruits: chemometric molecular networking reveals metabolic changes towards reduced toxicity over ontogeny in above-ground Solanum dulcamara chemotypes

This study uses metabolomics and chemometric analysis to show how toxic metabolites in Solanum dulcamara change during flower and fruit development, revealing detoxification processes in fruits.

Synthesis-driven reverse metabolomics reveals 3-hydroxy N-acyl amides as gut microbial molecules

The paper synthesizes 3-hydroxy N-acyl amides and uses reverse metabolomics to identify their presence in biological samples and link them to microbial production and metabolic disease.

Spatial metabolomics links polyamine turnover and vascular lipid remodeling to barley spikelet fate

The paper maps spatial metabolite distributions in barley inflorescences to link polyamine turnover and vascular lipid remodeling to spikelet fate.

Volatile Metabolic Signatures Reveal Early Pulmonary Responses to PFAS Exposure

This study identifies volatile organic compound (VOC) changes in lung cells exposed to PFAS, linking them to metabolic and transcriptional alterations.

An integrated platform for genome-wide functional analysis in Aspergillus niger through Ac/Ds insertion profiling and metabolic modeling

The paper develops a platform integrating transposon mutagenesis and metabolic modeling in Aspergillus niger to predict gene essentiality and guide strain engineering.

Multi-Omic Profiling Defines the Renal Mechanisms of Cardiovascular-Kidney-Metabolic Syndrome in Pulmonary Arterial Hypertension

This study uses multi-omic profiling to identify renal mechanisms in PAH, revealing structural and metabolic changes and potential therapeutic targets.

The Gibbs free energy landscape based on liver metabolome revealed thermodynamic robustness against fasting and obesity

The paper maps the Gibbs free energy landscape of liver metabolism in mice during fasting and obesity, revealing thermodynamic robustness despite metabolic changes.

Integrated Respirometry and Metabolomics Unveil Circadian Metabolic Dynamics in Drosophila

This study combines respirometry and metabolomics to analyze circadian metabolic dynamics in Drosophila, showing how sleep and circadian disruptions affect metabolic rates and redox homeostasis.

Constitutive PI3K-AKT activation promotes steatohepatitis through de novo lipogenesis despite enhanced mitochondrial β-oxidation, essential fatty acid depletion and reduced lipid peroxidation

A microbiome-derived metabolite from Staphylococcus epidermidis inhibits Staphylococcus aureus biofilm formation and virulence

This study identifies pyroglutamic acid as a metabolite from S. epidermidis that inhibits S. aureus biofilm formation and virulence in vitro and in vivo.

Enhancing Carbon Conversion Efficiency and Product Yield Through Systematic Biocatalyst Design for Microbial Electrosynthesis

This study enhances microbial electrosynthesis efficiency by optimizing biocatalyst conditions and anaerobic environments, achieving high CO2 conversion rates.

Trichome acylsugar defenses are equally effective against leaf-mining and free-living insects

The paper shows that trichome-produced acylsugars inhibit leafminer larvae growth and are translocated into mesophyll tissues via an ABC transporter, defending against both ectophagous and endophagous herbivores.

Enabling predictive modeling of molecular connections between fermented foods and human inflammation through a paired dataset of cell-based models and multi-omics approaches

The paper creates a paired dataset of fermented foods and human cell responses to enable predictive models of their anti-inflammatory effects through multi-omics approaches.

Morphine causes distinct changes in the lipidome throughout the brain and body after acute or chronic administration: implications for novel endogenous lipid signaling systems involved in opioid reward and withdrawal

This study examines how morphine alters lipid levels in different brain and body regions after acute or chronic administration, identifying potential endogenous lipid signaling systems involved in opioid reward and withdrawal.

Heterotrimeric Gβ subunit orchestrates flavonoid metabolism governing drought-tolerance in groundnut (Arachis hypogaea L.)

This study identifies AhGβ1 as a regulator of drought tolerance in groundnut by coordinating transcriptional and metabolic changes that enhance flavonoid production and reduce oxidative stress.

Multiomics Characterization Identifies S1P-secreting USSHigh Skeletal Muscle Stem Cells as Essential Drivers of Niche Remodeling and Muscle Regeneration

The paper identifies a senescent-like muscle stem cell subpopulation that drives muscle regeneration through secretory activity and cell communication.

Lysosomal proteome and lipidome analyses of intestinal cells reveal the crucial role of bis(monoacylglycero)phosphate for autophagosome-lysosome fusion

This study identifies BMP's role in autophagosome-lysosome fusion by analyzing lysosomal proteomes and lipidomes in GNPTAB-deficient intestinal cells.

A dependency-free, streamable format and cross-language toolkit for scalable LC-MS feature detection: reading only what you need

The paper introduces a new binary format and toolkit for efficient LC-MS data processing, enabling faster and more flexible feature detection.

ALDH2 Knockout Induces Dysregulation of Arginine biosynthesis in SKBR-3 Breast Cancer Cells

This study shows that ALDH2 knockout in SKBR-3 cells increases cellular stress and alters arginine biosynthesis and metabolism pathways.