Neurotransmitter Receptor Influence on Behavior

Concurrent measures of impulsive action and choice are partially related and differentially modulated by dopamine D1- and D2-like receptors in a rat model of impulsivity

This study examines the relationships between impulsive action, risky decision-making, and delay discounting in rats, and how they are modulated by dopamine receptor agonists.

Large-scale brain correlates of sweet versus cocaine reward in rats

The paper identifies brain regions associated with preference for sweet water over cocaine in rats using fos mapping, showing cocaine induces more global activation but saccharin activates regions related to taste and reward delay.

Computational modeling reveals latent components of mouse behavior in the sucrose preference test

The paper decomposes mouse behavior in the sucrose preference test to identify latent behavioral subcomponents and their relationship with stress and optogenetic interventions.

Vector-valued dopamine improves learning of continuous outputs in the striatum

This paper proposes a model where vector-valued dopamine signals enhance learning of continuous outputs in the striatum using a recurrent network and a local plasticity rule.

High frequency DBS-like optogenetic stimulation of nucleus accumbens dopamine D2 receptor-containing neurons attenuates cocaine reinstatement in male rats

The paper tests if optogenetic stimulation of specific dopamine receptor neurons in the nucleus accumbens reduces cocaine seeking in male rats, finding it reduces seeking when targeting D2DR neurons.

Balance between direct and indirect pathways of the nucleus accumbens controls social behavior in mice

This study investigates the role of D1R- and D2R-SPNs in the nucleus accumbens in modulating social behavior and related neuropsychiatric traits in mice.

Molecular, circuit, and stress response characterization of Ventral Pallidum Npas1-neurons

The paper characterizes VP Npas1+ neurons' projections, molecular identity, and role in stress response through RNA-seq and chemogenetic manipulation.

Effects of dopamine D2 and opioid receptor antagonism on the trade-off between model-based and model-free behavior in healthy volunteers

This study investigates how dopamine D2 and opioid receptor antagonism affects the balance between model-based and model-free behavior in healthy volunteers, finding that D2 antagonism increases model-based behavior while opioid antagonism has no significant effect.

Neuron Navigator 1 Regulates Learning, Memory, and the Response to Multiple Potentially Addictive Drugs

This study identifies Nav1 as a gene regulating learning, memory, and responses to addictive drugs through synaptic balance changes in the cortex and hippocampus.

THE ROLE OF ALPHA- AND BETA-ADRENERGIC RECEPTORS ONCOMPULSION-LIKE ALCOHOL DRINKING

This study investigates the role of alpha- and beta-adrenergic receptors in compulsion-like alcohol drinking using rat models and finds that propranolol reduces alcohol intake through mechanisms not limited to specific brain regions.

Differential Patterns of Synaptic Plasticity in the Nucleus Accumbens Caused by Continuous and Interrupted Morphine Exposure

This study compares synaptic plasticity in the nucleus accumbens under continuous vs interrupted morphine exposure in mice, finding divergent effects on inhibitory synapses and D1-MSN output.

Hypodopaminergic state of the nigrostriatal pathway drives compulsive alcohol use

Genetic pathways regulating the longitudinal acquisition of cocaine self-administration in inbred and recombinant inbred mice

The paper identifies genetic loci and pathways associated with cocaine self-administration in mice using GWAS and TWAS, highlighting Trpv2 as a key gene.

D-amphetamine maintenance therapy reduces cocaine use in female rats

This study shows that d-amphetamine maintenance therapy reduces cocaine use and motivation in female rats, both preventing and reversing increased cocaine seeking.

A permissive role for dopamine in the production of vigorous movements

This study investigates the role of dopamine in motor vigor, showing that it acts permissively rather than directly specifying movement speed and amplitude.

Incubation of palatable food craving is associated with brain-wide neuronal activation in mice

The paper establishes a mouse model of incubation of palatable food craving and identifies brain-wide activation patterns using whole-brain activity mapping.

Voluntary and forced exposure to ethanol vapor produces similar escalation of alcohol drinking but differential recruitment of brain regions related to stress, habit, and reward in male rats.

This study compares voluntary and forced ethanol exposure in rats, finding similar drinking escalation and blood alcohol levels but distinct brain region activation during withdrawal.

DAT Val559 Mice Exhibit Compulsive Behavior Under Devalued Reward Conditions Accompanied by Cellular and Pharmacological Changes

Biological Sex Influences the Contribution of Sign-Tracking and Anxiety-Like Behaviour toward Remifentanil Self-Administration

This study shows that biological sex moderates how personality traits like anxiety and sign-tracking affect remifentanil self-administration in rats.

Within-animal comparison of microdialysis and fiber photometry in amphetamine-exposed mice

The paper compares microdialysis and fiber photometry for measuring dopamine in awake mice after amphetamine exposure, finding good correlation between the two methods.

Nucleus-accumbens dopamine tracks aversive-stimulus duration and prediction but not value or prediction error

Striatal dopamine synthesis and cognitive flexibility differ between hormonal contraceptive users and non-users

This study compares dopamine synthesis and cognitive flexibility between hormonal contraceptive users and non-users using PET imaging and behavioral assessments.

Chronic restraint stress decreases resistance to punishment during cocaine self-administration via a dopamine D1-like receptor-mediated mechanism in prelimbic medial prefrontal cortex

This study shows chronic restraint stress reduces resistance to punishment during cocaine self-administration in male rats, an effect mediated by dopamine D1-like receptors in the prelimbic cortex.

The priming effect of rewarding brain stimulation persists following blockade of D2-like dopamine receptors

The paper withdraws its manuscript as its contents have been merged into another preprint.

Behavioral and dopaminergic signatures of resilience

The paper identifies behavioral and neural signatures of resilience to chronic stress by analyzing dopamine activity and behavior in mice during social defeat.

Glutathione in the nucleus accumbens regulates motivation to exert reward-incentivized effort

This study shows that higher glutathione levels in the nucleus accumbens predict better sustained performance in reward-incentivized effort tasks and that manipulating GSH levels affects motivation.

Reinstatement of Pavlovian responses to alcohol cues by stress

This study investigates how stress affects Pavlovian responses to alcohol-paired cues using a rat model, finding that yohimbine enhances responses but other stressors do not.

A novel pH-sensitive reporter reveals the cocaine-regulated trafficking of dopamine transporters in neuronal processes

This study uses a novel pH-sensitive reporter to show cocaine induces transient DAT internalization and prolonged membrane reinsertion in axons.

Towards a machine-learning assisted diagnosis of psychiatric disorders and their operationalization in preclinical research: evidence from studies on addiction-like behaviour in individual rats

The paper develops a machine-learning classifier to identify resilient or vulnerable rats in addiction-like behavior studies, showing high accuracy across different cohorts.

Activity of tonically active neurons in the primate striatum reflects interaction between time processing and reward prediction

This study investigates the role of tonically active neurons (TANs) in primate striatum, finding that their activity reflects interactions between time processing and reward prediction.