Neurotransmitter Receptor Influence on Behavior

Correspondence between gene expression and neurotransmitter receptor and transporter density in the human brain

The paper examines the relationship between gene expression and neurotransmitter receptor/transporter density in the human brain using PET and autoradiography, finding poor spatial correspondence except for four specific receptors.

Sexually dimorphic neural encoding of threat discrimination in nucleus accumbens afferents drives suppression of reward behavior

The paper investigates sex-specific neural encoding of threat and non-threat cues in nucleus accumbens afferents of male and female mice, revealing differences in behavior suppression.

Chronically elevated corticosterone impairsdopaminergic transmission in the dorsomedialstriatum by sex-divergent mechanisms

This study shows chronic corticosterone impairs reward-seeking in both sexes by sex-specific effects on dopamine content and transporter function in the dorsomedial striatum.

The locus coeruleus mediates behavioral flexibility

This study shows that locus coeruleus (LC) activity influences behavioral flexibility in mice by correlating with faster rule-switching behavior and improved task performance.

Haloperidol-induced immediate early genes in striatopallidal neurons requires the converging action of cAMP/PKA/DARPP-32 and mTOR pathways

The paper investigates how haloperidol induces immediate early genes in striatopallidal neurons through the combined action of cAMP/PKA/DARPP-32 and mTOR pathways.

Dopamine mediates the bidirectional update of interval timing

This study shows dopamine signals modulate subjective time speed during interval timing, supporting a unified theory of reinforcement learning and timing.

Nicotine Modifies Responding for Cocaine in a Concurrent Rodent Self-administration Model

This study examines how adding nicotine to cocaine self-administration in rats affects behavior under different reinforcement schedules, finding reduced responding under long access but increased responding under progressive ratio conditions.

Locus coeruleus norepinephrine selectively controls visual attention

The paper shows that locus coeruleus norepinephrine enhances visual attention by selectively improving sensory discrimination in non-human primates without affecting motor processing.

Common brain areas for processing physiologically and socially 'needed' stimuli

The paper identifies common brain regions activated by both physiologically and socially needed stimuli and links them to serotonin receptor distribution.

Dopamine regulates decision thresholds in human reinforcement learning.

This study investigates dopamine's role in human reinforcement learning using pharmacological interventions and fMRI, finding reduced decision thresholds under dopaminergic manipulations.

The development of compulsive coping behaviors depends on the engagement of dorsolateral striatum dopamine-dependent mechanisms

This study shows that compulsive coping behaviors in rats develop through dopamine-dependent mechanisms in the dorsolateral striatum after prolonged adjunctive drinking.

Predator odor (TMT) exposure potentiates interoceptive sensitivity to alcohol and increases GABAergic gene expression in the anterior insular cortex and nucleus accumbens in male rats

This study shows that predator odor exposure increases sensitivity to alcohol's interoceptive effects and boosts GABAergic gene expression in brain regions linked to stress and addiction.

Striatal dopamine explains novelty-induced behavioral dynamics and individual variability in threat prediction

The paper uses machine learning to analyze novelty-induced behaviors and finds that dopamine in the striatum correlates with individual variability and is explained by a reinforcement learning model of threat prediction.

Medial accumbens shell spiny projection neurons encode relative reward preference

The paper identifies how specific neurons in the medial accumbens shell encode reward preference and show distinct roles in driving reward behavior.

Metabotropic glutamate group II receptor activation in the dorsal striatum suppresses the motivation for cocaine in rats

This study shows that activating mGlu2/3 receptors in the dorsal striatum reduces cocaine-seeking behavior in rats after intermittent cocaine use.

Physiological constraints on the rapid dopaminergic modulation of striatal reward activity

This study investigates the rapid effects of dopaminergic modulation on striatal spiking activity and finds that physiological DA levels do not strongly influence spiking, except when DA exceeds reward-matched levels.

Learning of probabilistic punishment as a model of anxiety produces changes in action but not punishment encoding in the dmPFC and VTA

This study examines neural changes in dmPFC and VTA during probabilistic punishment learning and anxiolytic treatment in rats, finding adaptive responses independent of punishment experience.

Restoring functional D2- to D1-neuron correspondence enables goal-directed action control in long-lived striatal circuits

The paper investigates how restoring D2-to-D1-neuron functional correspondence in aged mice enhances goal-directed action by manipulating striatal neurons.

The individual vulnerability to develop compulsive adjunctive behavior is associated with the recruitment of activity-regulated cytoskeleton-associated protein (Arc) within the Locus Coeruleus

The paper identifies a correlation between low Arc mRNA levels in specific locus coeruleus neurons and the development of compulsive polydipsic drinking in rats.

Methamphetamine Self-Administration Differential Effects on Mesolimbic Glutathione Levels, Mitochondrial Respiration, and Dopamine Neuron Firing Activity

This study examines how long-term methamphetamine self-administration affects glutathione levels, mitochondrial respiration, and dopamine neuron activity in mice.

Differential role of dopamine D3 receptor through balanced modulation of Akt/mTOR and ERK1/2 activity in the reactivation of cocaine rewarding memories evoked by psychological versus physiological stress

This study investigates how D3 receptor antagonists modulate Akt/mTOR and ERK1/2 pathways in response to different stressors during cocaine relapse.

Local and long-distance inputs dynamically regulate striatal acetylcholine during decision making

The paper investigates how dopamine and acetylcholine interact in the striatum during decision making, revealing their dynamic relationship and the role of local and long-range inputs.

Intrinsic reward-like dopamine and acetylcholine dynamics in striatum

The paper shows that dopamine and acetylcholine levels in the striatum of mice fluctuate spontaneously with the same temporal relationship as during reward, driven by glutamatergic afferents rather than direct interactions between the neuromodulators.

Postpartum estrogen withdrawal induces deficits in affective behaviors and increases ΔFosB in D1 and D2 neurons in the nucleus accumbens core in mice

This study shows that postpartum estrogen withdrawal in mice increases anxiety-like behavior and ΔFosB expression in nucleus accumbens D1 and D2 neurons.

Cocaine addiction-like behaviors are associated with long-term changes in gene regulation, energy metabolism, and GABAergic inhibition within the amygdala

The paper identifies cell type-specific gene regulatory changes in the amygdala of rats with varying cocaine addiction-like behaviors, linking them to energy metabolism, GABAergic inhibition, and chromatin accessibility.

NPAS4 supports drug-cue associations and relapse-like behavior through regulation of the cell type-specific activation balance in the nucleus accumbens

This study shows NPAS4 regulates drug-cue associations and relapse-like behavior by controlling the activation balance between D1- and D2-MSNs in the nucleus accumbens.

Nonlinear computation by a habenula-driven recurrent inhibitory network in the raphe

The paper identifies a slow serotonergic recurrent inhibitory network in the dorsal raphe nucleus that generates non-linear dynamics and winner-take-all computations, affecting reward-conditioned behavior.

Lack of the glycine receptor alpha 2 increases striatal activity and motivated behavior

This paper shows that lack of the glycine receptor alpha 2 in mice increases striatal activity and motivated behavior, linking it to psychiatric disorders like schizophrenia and addiction.

Cell-type-specific whole-genome landscape of ΔFOSB binding in nucleus accumbens after chronic cocaine exposure

This study maps ΔFOSB binding sites in nucleus accumbens neurons after chronic cocaine exposure using CUT&RUN, revealing enhancer-like regions and interactions with BRG1 and other transcription factors.

Alcohol dependence modifies brain networks activated during abstinence and reaccess: a c-fos-based analysis in mice

The paper uses c-fos mapping and network analysis to show that alcohol dependence alters brain network activity during abstinence and reaccess in mice, with increased network modularity in high-drinking mice after reaccess.