HIV Research and Treatment

This study identifies structural adaptability in HIV-2 Vif that enables broad antagonism of APOBEC3G through conformational selection.

This study demonstrates that lipid nanoparticle-formulated RNA encoding a potent HIV-1 neutralizing antibody can durably suppress viremia in humanized mice.

This study uses single-molecule imaging to show peptide inhibitors bind to prefusion viral fusion proteins with varying stoichiometry and rapid kinetics, challenging the canonical prehairpin-intermediate model.

The paper identifies eicosanoid-enriched follicular microenvironments in HIV-infected individuals on antiretroviral therapy that may influence antibody responses and viral reservoir persistence.

The paper identifies a subset of HIV elite controllers with proteomic profiles similar to uninfected individuals, associated with lower viral reservoirs and protective HLA alleles.

This study uses single-molecule imaging to show that maturation inhibitors alter Gag conformational dynamics and spatial heterogeneity in immature HIV-1 virions.

In ART-suppressed human brain, an SPP1+ activated microglial subset holds most detected HIV RNA and shows chronic interferon-I and MHC-I signatures, alongside complement signaling and neuronal loss.

The paper identifies CypA as a molecular barrier preventing lentivirus from Eastern chimpanzees from infecting humans, due to its restriction of replication through a unique capsid feature.

This study uses coarse-grained models to simulate CPSF6 binding and oligomerization on HIV-1 capsid, revealing curvature-dependent interactions and their role in nuclear entry.

The paper determines the structure of HIV-1 capsid lattice bound to MxB N-terminal fragment, revealing an alpha-helix stabilizes binding at the trimer interface.

This paper models how memory CD8 T cells can drive post-treatment control of HIV by analyzing SIV-infected non-human primate data and developing a mathematical framework.

This study identifies novel compounds that inhibit HIV-1 replication in primary human macrophages by targeting epigenetic regulators.

The paper shows that 13 out of 16 SIV Vpr isolates activate DDR signaling and nuclear remodeling, with distinct amino acids involved across phylogenetic groups.

This paper develops a high-dimensional HIV-1 quasispecies model to predict viral rebound and guide antibody design without fitting to experimental data.

This study finds that opioid use disorder is linked to persistent immune dysregulation in HIV-positive individuals despite effective antiretroviral therapy.

This study uses spatial transcriptomics to identify compartment-specific immune activation signatures in ileal and lymph node tissues of HIV-treated patients, revealing tissue-specific transcriptional differences linked to immune activation and microbial translocation.

This paper determines the structure of HIV-1 NC(p7)1-55 and shows its interaction with p6, revealing how this interaction may regulate nucleic acid binding during viral assembly.

The paper develops a mechanistic model linking CD8+ T cell expansion sensitivity to HIV post-treatment control, showing strong correlations with Ki-67 and TCF-1 levels.

This study identifies CD205 as a B cell receptor that facilitates HIV-1 binding and transfer to CD4+ T cells through CD40L/IL-4 stimulation.

This study investigates allosteric capsid inhibitors and their resistance mutants, showing they trigger innate immune responses and may reduce HIV-1 transmission.

This study uses ultra-deep single-genome sequencing to show strong purifying selection in early HIV-1 infection, with limited early genetic divergence from founder viruses.

This study shows that inhibiting REV-ERBβ increases HIV-1 reactivation in CD4+ T-cells but limits virion spread.

This paper introduces a new HIV-1 latency reversing agent, D10, which activates HIV-1 Tat to induce viral production from latent cells.

The paper maps glycan composition across HIV-1 pseudoviruses to show how sequence diversity affects the glycan shield and its vulnerability to broadly neutralizing antibodies.

The paper shows that boosting at the same site as the initial immunization preferentially engages bnAb lineage precursors in secondary germinal centers, while contralateral boosting recruits naive and non-specific memory B cells.

The paper identifies a unique CD8+ T cell population that expands during ART and predicts delayed HIV-1 rebound.

This study identifies APOBEC3G splicing defects in nonhuman primates that lead to different viral mutation profiles compared to humans.

This study identifies chromatin regulators of HIV latency and reactivation using RelB proximity proteomics and CRISPR screening, revealing key acetyltransferases involved in noncanonical NF-κB pathway activation.