Stress Responses and Cortisol

Rapid volumetric brain changes after acute psychosocial stress

This study examines rapid volumetric brain changes after acute psychosocial stress using MRI and finds significant group-by-time interactions in grey matter volume and associations with stress measures.

Effects of early life stress and subsequent re-exposure to stress on neuronal activity in the lateral habenula

This study investigates how early life stress and re-exposure to stress affect neuronal activity in the lateral habenula of adult mice, finding that hypoactivity and sensitized responses contribute to depressive-like behaviors.

CRF neurons of the BNST promote resilience by blunting the internal experience of aversion.

This study shows BNSTovCRF neurons promote resilience by reducing the internal experience of aversion during stress.

Early life trauma leads to escalated aggressive behavior and its inheritance by impairing thyroid hormone availability in brain

This study identifies transthyretin (TTR) as a key regulator of escalated aggression and its intergenerational inheritance through impaired thyroid hormone availability in the brain.

Site-Specific Knockdown of Microglia in the Locus Coeruleus Regulates Hypervigilant Responses to Social Stress in Female Rats

This study shows that microglia in the locus coeruleus of female rats influence hypervigilant responses to social stress, with site-specific microglia depletion reducing stress-induced behaviors.

Optogenetic induction of chronic glucocorticoid exposure in early-life impairs stress-response in larval zebrafish.

This study uses optogenetics to chronically activate glucocorticoid signaling in larval zebrafish, showing impaired stress response and reduced POMC-expressing cells.

Got Milk? Maternal immune activation during the mid-lactational period affects nutritional milk quality and adolescent offspring sensory processing in male and female rats

This study shows that maternal immune activation during lactation alters milk composition and leads to behavioral and physiological changes in offspring.

What the hippocampus tells the HPA axis: Hippocampal output attenuates acute stress responses via disynaptic inhibition of CRF+ PVN neurons

The paper demonstrates that hippocampal output to the BNST inhibits the HPA axis by disynaptic inhibition of CRF+ PVN neurons during acute stress.

Long lasting anxiety following early life stress is dependent on glucocorticoid signaling in zebrafish

This study shows that early life stress in zebrafish affects glucocorticoid signaling during a critical developmental window, leading to long-term anxiety-like behavior and cortisol dysregulation.

Molecular and cellular adaptations in hippocampal parvalbumin neurons mediate behavioral responses to chronic social stress

Impaired developmental microglial pruning of excitatory synapses on CRH-expressing hypothalamic neurons exacerbates stress responses throughout life

The paper shows that early-life adversity impairs microglial pruning of excitatory synapses on CRH-expressing hypothalamic neurons, leading to heightened stress responses later in life.

Long-term consequences of alcohol use in early adolescent mice: focus on neuroadaptations in GR, CRF and BDNF

This study examines long-term effects of adolescent alcohol exposure on behavior and neurobiological markers in mice, finding persistent anxiety and changes in GR, CRF, and BDNF expression in limbic brain regions.

Characterizing the Behavioral and Neuroendocrine Features of Susceptibility and Resilience to Social Stress

The paper characterizes behavioral, physiological, and neuroendocrine profiles of mice before, during, and after chronic social defeat stress, finding that early coping strategies better predict resilience or susceptibility than traditional behavioral read-outs.

Alpha-Amylase increases predict a freezing-like response and cortical alpha oscillations

The paper investigates the relationship between sympathetic nervous activity, measured via salivary alpha-amylase, and changes in alpha power and freezing-like behavior during exposure to affective stimuli.

Recruitment of Corticotropin-releasing Hormone CRH Neurons in response ton Categorically Distinct Stress Challenges in the Mouse Brain

The paper investigates CRH neuron activation in response to different stressors in mice, identifying differential activation patterns across brain regions.

Structural changes after early life adversity in rodents: a systematic review with meta-analysis

This paper conducts a meta-analysis of 64 studies to assess structural brain changes in rodents exposed to early life adversity, finding reduced hippocampal volume and dendritic growth in male rats.

Effects of early life adversity on immediate early gene expression: systematic review and 3-level meta-analysis of rodent studies

This study reviews 39 rodent studies on early-life adversity's effects on immediate-early gene expression, finding that ELA increases cFos expression under specific conditions.

Stress-induced epigenetic regulation of transcription in neocortical excitatory neurons drives depression-like behavior

The paper identifies epigenetic changes in neocortical excitatory neurons under chronic stress that contribute to depression-like behaviors in mice.

Glucocorticoid receptor dysregulation underlies 5-HT2A receptor-dependent synaptic and behavioral deficits in a mouse neurodevelopmental disorder model

This study identifies a negative regulatory relationship between glucocorticoid receptor signaling and 5-HT2A receptor expression in a mouse model of neurodevelopmental disorder, linking it to synaptic and behavioral deficits.

Association of stress-related neural activity and baseline interleukin-6 plasma levels in healthy adults

This study links baseline interleukin-6 plasma levels to neural stress responses in healthy adults, finding negative associations in specific brain regions.

Single-Cell transcriptional changes in hypothalamic CRH-expressing neurons after early-life adversity inform enduring alterations in responses to stress

This study uses single-cell RNA sequencing to identify lasting transcriptional changes in hypothalamic CRH-expressing neurons after early-life adversity, linking these changes to long-term stress responses.

Sustained TNF signaling is required for the synaptic and behavioral response to acute stress

This study shows that sustained TNF signaling in the ventral hippocampus is necessary for stress-induced synaptic and behavioral changes in mice.

Effects of chronic exposure to fluoxetine, eicosapentaenoic acid, and lipopolysaccharide on behavior and hippocampal transcriptome in the rat model of prolonged chronic unpredictable stress

This study examines the effects of chronic exposure to fluoxetine, EPA, and LPS on behavior and hippocampal transcriptome in a rat model of prolonged chronic unpredictable stress, identifying potential therapeutic targets.

Biological Factors and Self-Perception of Stress Predict Human Freeze-Like Responses in the Context of Self-Defence Training and Personal Experience with Violence

The paper shows that simulated physical attacks induce freeze-like responses in men, with EDA, stress perception, and fMRI activity predicting the response, but only in relation to training and experience levels.

Three water restriction schedules used in rodent behavioral tasks transiently impair growth and differentially evoke a stress hormone response without causing dehydration

This study examines the effects of three water restriction schedules on rodent growth, hydration, and stress hormone levels over 80 days, finding no dehydration but differential stress responses.

Chronic stress induces coordinated cortical microcircuit cell type transcriptomic changes consistent with altered information processing

The paper investigates transcriptomic changes in cortical microcircuit cell types under chronic stress and finds coordinated shifts in gene expression patterns associated with altered excitation-inhibition balance.

History of winning and hierarchy landscape influence stress susceptibility in mice

The paper shows that social rank and history of winning influence stress susceptibility in mice, with dominance conferring resilience and subordination increasing susceptibility.

Behavioral and Neurostructural changes associated with Chronic Amygdala Hyperactivation

This study shows chronic amygdala hyperactivation in mice increases anxiety and may worsen stress-induced anxiety but does not cause depressive-like behaviors.

Hippocampal astroglial hypertrophy in mice subjected to early life maternal deprivation

This study shows that maternal deprivation in early life leads to astrocyte hypertrophy in the hippocampus of mice as late as 8 months of age.

Chronic adolescent stress increases exploratory behavior but does not change the acute stress response in adult male C57BL/6 mice

This study shows that chronic adolescent stress increases exploratory behavior and hippocampal gene expression but does not affect acute stress responses in adult mice.