Genetics, Aging, and Longevity in Model Organisms

Genome-wide reversal of glial and neurovascular cell transcriptomic aging signatures by GLP-1R agonism

This study shows GLP-1R agonism reverses transcriptomic aging in brain cells and reduces AD-associated signatures in microglia.

Optogenetic control of gut bacterial metabolism to promote longevity

This study uses optogenetic control to manipulate gut bacterial metabolism in C. elegans and shows that increased colanic acid production extends lifespan.

The PP2A/4/6 subfamily of phosphoprotein phosphatases regulates DAF-16 during aging and confers resistance to environmental stress in postreproductive adult C. elegans

This study identifies PP2A/4/6 phosphatase subunits that regulate DAF-16 activity and confer stress resistance in aging C. elegans.

Class I histone deacetylase HDA-3 is required for full maintenance of locomotor ability in Caenorhabditis elegans

This study identifies HDA-3 as a genetic factor contributing to locomotor ability maintenance in C. elegans and finds that mutations in HDA-3 and related genes lead to progressive locomotor decline.

A Multicellular Network Mechanism for Temperature-Robust Food Sensing

This study shows how C. elegans maintains food-responsiveness across temperature changes through a multicellular gene network involving TGF-β and serotonin signaling.

Healthy aging interventions reduce non-coding repetitive element transcripts

The paper investigates how healthy aging interventions affect non-coding repetitive element transcripts in mice and humans, finding they are globally reduced by interventions and increased by aging.

Cellular proteostasis decline in human senescence

This study shows proteostasis decline in human senescence through transcriptome-wide analysis, revealing impaired transcriptional responses and proteasome function.

Identifying Longevity Associated Genes by Integrating Gene Expression and Curated Annotations

The paper compares classification algorithms to predict pro- and anti-longevity genes using gene expression and ontology data in C. elegans and S. cerevisiae, finding elastic net logistic regression performs best.

ninaD regulates cholesterol homeostasis from the midgut which protects against neurodegeneration

The paper shows that ninaD, a gene upregulated in gut cells, regulates cholesterol homeostasis and protects against neurodegeneration by a gut-brain axis mechanism.

DAF-18 is required for the age-dependent increase in DAF-16 activity in Caenorhabditis elegans

This study shows DAF-18 is required for age-dependent DAF-16 activation in C. elegans, contributing to immunity and functioning through post-translational modifications.

C. elegans hermaphrodites undergo semelparous reproductive death

The paper shows that C. elegans hermaphrodites undergo reproductive death after reproduction, which is suppressed by germline removal and linked to lifespan extension.

C. elegans provide milk for their young

This study shows that C. elegans mothers transfer yolk to offspring via lactation, a process promoted by insulin/IGF-1 signalling, leading to reproductive death.

The genetic paradigms of dietary restriction fail to extend life span in cep-1(gk138) mutant of C. elegans p53 due to possible background mutations

The study shows that CEP-1 is not required for genetic dietary restriction-mediated longevity in C. elegans, but background mutations may explain the observed phenotypes.

Social chemical communication determines recovery from L1 arrest via DAF-16 activation

This study shows that social chemical communication via trehalose and DAF-16 activation enhances recovery from L1 arrest in C. elegans.

Impact of high-fat diet on lifespan, metabolism, fecundity and behavioral senescence in Drosophila

This study examines the effects of high-fat diet on lifespan, metabolism, fecundity, and behavioral senescence in Drosophila, finding accelerated aging and impaired reproductive and motor functions.

AMPK Modulates Associative Learning via Neuronal Mitochondrial Fusion in C. elegans

This study shows that AMPK enhances associative learning in C. elegans by promoting neuronal mitochondrial fusion, which is critical for maintaining neuronal function with age and in neurodegenerative conditions.

Dormancy-to-death transition in yeast spores occurs due to gradual loss of gene-expressing ability

The paper shows that yeast spores age by gradually losing gene-expressing ability, leading to death when this ability is irreversibly lost.

SynergyAge: a curated database for synergistic and antagonistic interactions of longevity-associated genes

SynergyAge curates genetic and lifespan data from animal models with multiple longevity-modulating interventions to explore synergistic and antagonistic gene interactions.

The Synergy of Damage Repair and Retention Promotes Rejuvenation and Prolongs Healthy Lifespans in Cell Lineages

The paper shows that damage retention and early repair in yeast promote rejuvenation and longer healthy lifespans by reducing damage variability and stress susceptibility.

High-resolution yeast quiescence profiling in human-like media reveals interacting influences of auxotrophy and nutrient availability

The paper investigates factors influencing yeast quiescence using defined media, revealing interactions between auxotrophy, nutrient availability, and signaling pathways.

PQM-1 controls hypoxic survival via regulation of lipid metabolism

This study identifies PQM-1 as a regulator of hypoxic survival in C. elegans by modulating lipid metabolism and oxygen consumption, with trade-offs between maternal and progeny survival.

Rhesus macaques as a tractable physiological model of human ageing

This paper reviews rhesus macaques as a model for human ageing, showing shared gene regulatory signatures in immune ageing between macaques and humans.

An accurate aging clock developed from the largest dataset of microbial and human gene expression reveals molecular mechanisms of aging

This paper develops an aging clock using human and microbial gene expression data, showing associations between biological age and lifestyle factors.

NHR-49 acts in distinct tissues to promote longevity versus innate immunity

This study shows that NHR-49 promotes longevity and innate immunity in C. elegans through distinct tissue-specific mechanisms and transcriptional programs.

Single-cell RNA-seq reveals early heterogeneity during ageing in yeast

This study uses scRNA-seq to analyze yeast ageing, finding increased transcriptional variability and identifying FIT3 as a marker of early heterogeneity.

Discovering compounds mimicking calorie restriction using mammalian gene expression profiles

The paper identifies compounds that mimic calorie restriction by inducing liver gene signatures similar to those observed under calorie restriction in mice and rats.

Polyploidy in the adult Drosophila brain

This study shows that polyploid cells accumulate in the ageing Drosophila brain and are more resistant to DNA damage-induced cell death than diploid cells.

Distinct aging-vulnerable trajectories of motor circuit functions in oxidation- and temperature-stressed Drosophila

This study identifies age-vulnerable motor circuit functions in Drosophila under oxidative and temperature stress, showing distinct aging patterns and highlighting potential neurophysiological markers.

Social reprogramming in ants induces longevity-associated glia remodeling

The paper uses single-cell RNA-sequencing to show that caste transition in ants leads to glia remodeling associated with extended lifespan.

The SOD-2 protein is the single active SOD enzyme in C. elegans

The paper identifies SOD-2 as the only active SOD enzyme in C. elegans through in-gel activity analysis and mutant studies.