Genetics, Aging, and Longevity in Model Organisms

RNAAgeCalc: A multi-tissue transcriptional age calculator

RNAAgeCalc calculates transcriptional age across tissues using age-related genes identified from GTEx and validates its predictive power using TCGA data.

Targeted downregulation of estradiol binding Na+/H+ exchanger nhx-2, mimics calorie restriction, extends reproductive longevity and ameliorates effects associated with alpha synuclein aggregation in C. elegans

This study identifies nhx-2 as a modulator that extends reproductive longevity and ameliorates alpha-synuclein aggregation effects in C. elegans by mimicking dietary restriction.

The SEM-4 transcription factor is required for regulation of the oxidative stress response in Caenorhabditis elegans

The paper identifies SEM-4 as a transcription factor required for regulating oxidative stress response by activating skn-1c and phase II detoxification genes in C. elegans.

ADAM17-triggered TNF signalling protects the ageing Drosophila retina from lipid droplet mediated degeneration

The paper shows that ADAM17-triggered TNF signaling in Drosophila retina protects against age-related lipid droplet-mediated degeneration by initially buffering ROS but later causing toxic lipid release.

Multidimensional phenotyping predicts lifespan and quantifies health in C. elegans

The paper uses multidimensional phenotyping of C. elegans to predict lifespan and quantify health, showing that more features improve prediction accuracy.

Daphnia magna modifies its gene expression extensively in response to caloric restriction revealing a novel effect on haemoglobin isoform preference

This study shows that caloric restriction in Daphnia magna causes extensive gene expression changes, including a shift in haemoglobin isoform preference, similar to hypoxia responses.

An epigenetic landscape governs early fate decision in cellular aging

The paper shows that interactions between chromatin silencing and mitochondrial pathways create an epigenetic landscape that determines cell fate during aging, and introduces a genetically engineered long-lived state.

Age-dependent ribosomal DNA variations and their effect on cellular function in mammalian cells

This study identifies age-dependent changes in rDNA copy number, methylation, and sequence variations in mice, linking these alterations to reduced pre-rRNA levels and shortened yeast lifespan.

Healthspan pathway maps in C. elegans and humans highlight transcription, prolifera-tion/biosynthesis and lipids

The paper compiles healthspan-related gene pathways in C. elegans and humans using literature review and molecular interaction data, identifying common themes like transcription and lipids.

Mapping Drosophila insulin receptor structure to the regulation of aging through analysis of amino acid substitutions

The paper identifies an amino acid substitution in the Drosophila insulin receptor that extends lifespan without affecting growth or reproduction.

The genome of North American beaver provides insights into the mechanisms of its longevity and cancer resistance

This study identifies genes contributing to beaver longevity and cancer resistance through genomic analysis of gene copy number, expression, and evolutionary changes.

Multi-faceted deregulation of gene expression and protein synthesis with age

This study examines age-related changes in the transcriptome and translatome of mouse tissues, revealing U-shaped gene expression patterns and age-related declines in protein synthesis.

IMPACT OF PHENOLIC ACIDS ON THE ENERGY METABOLISM AND LONGEVITY IN C. ELEGANS

This study examines the effects of phenolic acids on aging and metabolism in C. elegans, finding they improve lifespan and stress resistance but do not enhance mitochondrial function.

Identification and genomic analysis of pedigrees with exceptional longevity identifies candidate rare variants

The paper identifies rare genetic variants associated with exceptional longevity through pedigree analysis and genomic screening in Utah populations.

CREB non-autonomously regulates Reproductive Aging through Hedgehog/Patched Signalling

This paper shows that CREB regulates reproductive aging in C. elegans by controlling a Hedgehog-related signaling factor, WRT-10, through the TGF-β Sma/Mab pathway in the hypodermis.

Genome-wide analysis reveals distinct genetic mechanisms of diet-dependent lifespan and healthspan in D. melanogaster

The paper identifies genetic mechanisms underlying diet-dependent lifespan and healthspan in D. melanogaster using GWAS and validates gene effects on lifespan and climbing ability.

Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation

This study shows that reduced proteasome activity in aging brains leads to ribosome stoichiometry loss and aggregation, increasing mortality risk in killifish.

An Optimized Competitive-Aging Method Reveals Gene-Drug Interactions Underlying the Chronological Lifespan of Saccharomyces cerevisiae

The paper introduces an optimized competitive-aging method to identify gene-drug interactions affecting yeast chronological lifespan, revealing a link between protein glycosylation and metformin-induced lifespan extension.

Hypoxic response regulators RHY-1 and EGL-9/PHD promote longevity through a VHL-1 independent transcriptional response.

This study shows that mutations in egl-9 and rhy-1 suppress the long-lived phenotype of vhl-1 mutants in C. elegans, indicating a VHL-1-independent role for EGL-9 and RHY-1 in longevity regulation.

An evolutionarily conserved metallophosphodiesterase is a determinant of lifespan in Drosophila

This study identifies a conserved metallophosphodiesterase in Drosophila that influences lifespan, with neuronal expression capable of rescuing lifespan defects.

The changes in the p53 protein across the animal kingdom pointing to its involvement in longevity

The paper investigates amino acid variations in p53 across species and finds correlations between specific substitutions and extended lifespan.

C. elegans processes sensory information to choose between freeloading and self-defense strategies

The paper identifies a neuronal circuit in C. elegans that modulates hydrogen peroxide defenses based on sensory input and bacterial presence.

Intragenic repeat expansions control yeast chronological aging

The paper identifies intragenic repeat expansions in yeast that influence chronological aging by altering cellular metabolism and environmental interaction.

The self-organization model reveals systematic characteristics of aging

This paper models the aging self-organization system using supervised learning to optimize aging networks and study molecular mechanisms of aging and related diseases.

The landscape of longevity across phylogeny

The paper analyzes longevity interventions across species and identifies a structured 'landscape of longevity' with soft bounds on achievable lifespan, including a human upper limit of ~138 years.

C. elegans ELT-3 regulates cuticle collagen expression in response to environmental stimuli

The paper identifies ELT-3 as a GATA transcription factor that regulates cuticle collagen expression in C. elegans in response to environmental stimuli.

The GATA transcription factor Gaf1 represses tRNA genes, inhibits growth, and extends chronological lifespan downstream of fission yeast TORC1

Transcriptome analysis reveals the difference between \"healthy\" and \"common\" aging and their connection with age-related diseases

The paper compares gene regulations in 'healthy' and 'common' aging using GTEx data to identify differences and connections with age-related diseases.

Agewise mapping of genomic oxidative DNA modification demonstrates oxidative-driven reprogramming of pro-longevity genes

The paper maps oxidative DNA damage in C. elegans across age periods, showing age-specific patterns and a negative association between oxidative modification and pro-longevity gene expression.

Hedgehog Signalling Modulates Glial Proteostasis and Lifespan.

This study shows that Hedgehog signaling in Drosophila glial cells protects proteostasis and extends lifespan, with potential therapeutic implications for degenerative diseases.