Genetics, Aging, and Longevity in Model Organisms

Ribosome protein mutant cells rely on the GR64 cluster of gustatory receptors for survival and proteostasis in Drosophila

The paper shows that Rp/+ cells in Drosophila rely on Gr64 gustatory receptors for survival and proteostasis by maintaining autophagy and proteasome function.

Dietary restriction and clock delay eye aging to extend lifespan in D. melanogaster

This study shows dietary restriction extends lifespan in D. melanogaster by protecting the visual system from age and light-related damage through circadian regulation.

Biological mechanisms of aging predict age-related disease multimorbidities in patients

The paper identifies aging mechanisms that predict age-related disease multimorbidities in humans using literature analysis and clinical data integration.

Mitochondrial unfolded protein response transcription factor ATFS-1 increases resistance to exogenous stressors through upregulation of multiple stress response pathways

This study shows that ATFS-1 activates multiple stress response pathways to increase resistance to exogenous stressors but reduces lifespan when chronically active.

DAF-16/FoxO and DAF-12/VDR control cellular plasticity both cell-autonomously and via interorgan signaling

The paper shows that DAF-16/FoxO and DAF-12/VDR control cellular plasticity both cell-autonomously and through interorgan signaling in C. elegans.

Natural variations in reproductive timing of brood size and X-chromosome nondisjunction in Caenorhabditis elegans

The paper measures brood size and male-production rate in 96 C. elegans wild strains across reproductive periods, finding they are not genetically correlated and identifying loci associated with male-production rate.

Serotonin and dopamine modulate aging in response to food perception and availability

The paper identifies compounds that block food perception in C. elegans, increasing longevity by modulating serotonin and dopamine signaling, suggesting a mechanism by which dietary restriction mimetics extend lifespan.

mir-71 mediates age-dependent opposing contributions of the stress activated kinase KGB-1 in Caenorhabditis elegans

This study identifies mir-71 as a mediator of age-dependent antagonistic effects of KGB-1 in C. elegans, showing it regulates DAF-16 and influences both early-life stress resistance and late-life survival.

The HPA stress axis shapes aging rates in long-lived, social mole-rats

The paper investigates how the HPA stress axis influences aging in long-lived mole-rats, finding that reproductive status affects stress regulation and lifespan.

Bacterial processing of glucose modulates C. elegans lifespan and healthspan

This study shows that E. coli processing of glucose reduces C. elegans lifespan and healthspan by increasing oxidative stress and decreasing detoxification gene expression.

DNA methylation clocks show slower progression of aging in naked mole-rat queens

This study develops DNA methylation clocks for naked mole-rats and finds that queens age more slowly than non-breeders, suggesting a link between reproductive status and epigenetic aging.

eIF2B extends lifespan through inhibition of the integrated stress response

This study identifies eIF2B's role in extending lifespan by inhibiting the integrated stress response in C. elegans, improving protein homeostasis without altering overall protein synthesis.

Proteomic and transcriptomic profiling reveal different aspects of aging in the kidney

This study profiles mRNA and protein levels in aging kidneys, finding that protein changes reveal more extensive and functionally significant aging-related alterations than mRNA.

Differential effects on neuromuscular physiology between Sod loss-of-function mutation and paraquat-induced oxidative stress in Drosophila

This study compares the effects of Sod loss-of-function mutations and paraquat-induced oxidative stress on neuromuscular physiology in Drosophila, finding distinct impacts on neurotransmission.

Neuronal SKN-1B Modulates Nutritional Signalling Pathways and Mitochondrial Networks to Control Satiety

This study identifies SKN-1B in C. elegans as a central food-responsive node that controls satiety and metabolic homeostasis by modulating endocrine pathways and mitochondrial networks.

A transcriptome based aging clock near the theoretical limit of accuracy

This paper develops a transcriptome-based aging clock for C. elegans with high accuracy, applicable to human age prediction.

Reduction of insulin/IGF-1 receptor rejuvenates immunity via positive feedback circuit

This study shows that reducing insulin/IGF-1 receptor activity delays immunosenescence and rejuvenates immunity in C. elegans through a positive feedback circuit involving DAF-16/FOXO and HSF-1.

Ageing Transcriptome Meta-Analysis Reveals Similarities Between Key Mammalian Tissues

This study identifies common ageing transcriptomic signatures across mammalian tissues using meta-analysis and machine learning, revealing shared functional changes and network properties.

FOXO regulates neuromuscular junction homeostasis during Drosophila aging

This study shows FOXO maintains neuromuscular junction integrity during aging in Drosophila by repressing MAPK signaling.

miR-1 coordinately regulates lysosomal v-ATPase and biogenesis to affect muscle contractility upon proteotoxic challenge during ageing

This study shows that miR-1 regulates lysosomal v-ATPase and biogenesis in C. elegans muscle to affect contractility during proteotoxic stress and ageing.

Biogenic Amine Neurotransmitters Promote Eicosanoid Production And Protein Homeostasis

This study shows that biogenic amines in C. elegans regulate proteostasis by promoting eicosanoid production and UPS activity through cytochrome P450 enzymes.

Serotonin 2A receptor signaling coordinates central metabolic processes to modulate aging in response to nutrient choice

This study shows that nutrient choice affects aging in Drosophila through serotonin 2A receptor signaling and metabolic reprogramming.

Transcriptomic profiling of long- and short-lived mutant mice implicates mitochondrial metabolism in ageing and shows signatures of normal ageing in progeroid mice

This study compares transcriptomic changes in long- and short-lived mouse models of ageing, identifying mitochondrial metabolism as a key factor and showing that progeroid mice exhibit gene expression patterns similar to normal ageing.

Multiple genetic pathways regulating lifespan extension are neuroprotective in a G2019S LRRK2 nematode model of Parkinson's disease

The paper investigates how lifespan-extending genetic pathways provide neuroprotection in a nematode model of Parkinson's disease, showing dissociation between lifespan extension and neuroprotection.

Steroid hormones sulfatase inactivation extends lifespan and ameliorates age-related diseases

This study shows that inactivating steroid sulfatase in C. elegans extends lifespan and reduces age-related diseases, suggesting potential therapeutic applications for aging.

Long term consumption of green tea EGCG enhances healthspan and lifespan in mice bymitigating multiple aspects of cellular senescence in mitotic and post-mitotic tissues, gutdysbiosis and immunosenescence

This study shows that long-term green tea EGCG consumption improves healthspan and lifespan in mice by reducing cellular senescence, gut dysbiosis, and immunosenescence.

Histone H2A ubiquitination resulting from Brap loss of function connects multiple aging hallmarks and accelerates neurodegeneration

This study shows Brap loss leads to H2A ubiquitination, causing aging hallmarks and neurodegeneration in mice, with similar findings in Alzheimer's human brain tissue.

Increasing glucose uptake into neurons antagonizes brain aging and promotes health and life span under dietary restriction in Drosophila

This study shows that increasing glucose uptake in Drosophila neurons improves ATP levels, reduces aging-related deficits, and extends lifespan, especially under dietary restriction.

Fatty acid metabolic reprogramming promotes C. elegans development

This study shows that fatty acid metabolic reprogramming in C. elegans is essential for development on a specific diet, mediated by acetylcholine signaling and the fatty acid elongase gene elo-6.

Interspecies differences in proteome turnover kinetics are correlated with lifespans and energetic demands

The paper measures protein turnover rates in fibroblasts from long-lived species and finds slower turnover correlates with longer lifespan and reduced ROS.