Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities

Interplay of genotypic and thermal sex determination shapes climatic distribution in herpetofauna

The paper shows that the climatic distribution of amphibians and reptiles is shaped by the interaction between genotypic and temperature-dependent sex determination systems.

Tissue-specific metabolomic signatures for a doublesex model of reduced sexual dimorphism

The paper investigates how knocking out the doublesex gene in Drosophila affects metabolomic differences between sexes, finding that dsx significantly influences sex-specific metabolites across tissues.

Sex effects on gene expression across the human cerebral cortex at single cell resolution

This study identifies sex-biased gene expression patterns across multiple cortical regions and cell types in the human brain using single-cell transcriptomics.

The evolution of separate sexes in waterhemp is associated with surprising chromosomal diversity and complexity

This study investigates the genetic basis of sex determination in waterhemp, revealing complex chromosomal diversity and phenotypic variability associated with the transition to dioecy.

A porcine germ cell depletion model to investigate the role of germ cells in gonadal development.

This study uses a porcine model to show that germ cell depletion leads to defects in gonadal somatic cell development, highlighting germ cells' role in shaping gonadal structure.

Evolution and functioning of an X-A balance sex determination system in hops

The paper studies the evolution of an X-A balance sex determination system in hops by analyzing genome sequences of two hop species and identifies a candidate gene involved in the system.

The evolution of gene regulatory programs controlling gonadal development in primates

This study analyzes gene regulatory programs in primate gonads, finding shared and species-specific regulatory dynamics and candidate genes for sex development disorders.

The Masc-PSI complex directly induces male-type doublesex splicing in silkworms

This study identifies the BmMasc-BmPSI complex as essential for male-type Bmdsx splicing in silkworms by binding to female-specific introns and exons.

Loss of chromosome Y shapes the immune cell fate with aging in men

The paper shows that loss of chromosome Y in immune cells of aging men affects cell fate and X-chromosome inactivation patterns.

The Driving W Hypothesis as an Explanation for Low Within-Population Mitochondrial DNA Diversity and Between-Population Mitochondrial Transfer

The paper proposes and evaluates the W-mtDNA Drive Hypothesis to explain low within-population mitochondrial DNA diversity and between-population mitochondrial transfer.

The SHR/Akr Y chromosome reveals repeated turnover of the rat pseudoautosomal region

The paper sequences the rat Y chromosome and reveals a short pseudoautosomal region with high recombination rate and unique evolutionary features.

Early establishment and life course stability of sex biases in the human brain transcriptome

The paper examines sex biases in the human brain transcriptome across development and adulthood, finding that many sex differences originate in the prenatal period and persist into adulthood.

Disentangling sex-ratio meiotic drive in Drosophila a century after its original discovery

The paper investigates sex-ratio meiotic drive in Drosophila obscura by identifying a driver gene and a suppressor miRNA, revealing an evolutionary arms race between them.

Demographic pathways linking sex-chromosome system to adult sex ratio variation across tetrapods

The paper investigates how sex-chromosome systems influence adult sex ratios in tetrapods through demographic processes like adult mortality and maturation timing.

The fourspine stickleback (Apeltes quadracus) has an XY sex chromosome system with polymorphic inversions on both X and Y chromosomes

The paper identifies an XY sex chromosome system in fourspine stickleback with polymorphic inversions on both X and Y chromosomes, revealing new insights into sex chromosome evolution.

In-depth investigation of genome to refine QTL positions for spontaneous sex-reversal in XX rainbow trout

The paper investigates QTL regions associated with spontaneous sex-reversal in XX rainbow trout using genome-based approaches and statistical methods to identify potential sex-modifier genes.

Whole-genome sequencing reveals the molecular basis of sex determination in the dioecious wild yam Dioscorea tokoro

The paper identifies two candidate genes involved in sex determination in the dioecious wild yam Dioscorea tokoro using whole-genome sequencing and genetic analysis.

A re-evaluation of Muller's sheltering hypothesis for the evolution of sex chromosome gene content

This paper reevaluates Muller's sheltering hypothesis for sex chromosome evolution, finding that restrictive assumptions in earlier models may have excluded its validity.

Convergent Evolution of H4K16ac-mediated Dosage Compensation Shapes Sex-dependent Lifespan in a ZW Species

This study identifies convergent evolution of H4K16ac-mediated dosage compensation in a ZW species and links it to sex-dependent lifespan differences.

Sexual size dimorphism correlates with the number of androgen response in mammals, but only in small-bodied species

The paper examines sexual size dimorphism in mammals, finding that androgen response elements correlate with SSD in small-bodied species but not in larger ones.

The pioneer factor Zelda induces male-to-female somatic sex reversal in adult tissues

The paper shows that the pioneer factor Zelda induces female-specific traits in male Drosophila tissues by upregulating genes that promote feminization and override male identity.

Survey of gene, lncRNA and transposon transcription patterns in four mouse organs highlights shared and organ-specific sex-biased regulation

The paper examines sex-biased transcription of genes, lncRNAs, and TEs in four mouse organs, finding organ-specific patterns and clustering of sex-biased TEs near sex-biased genes and lncRNAs.

Single-nucleus multiomics reveals the gene-regulatory networks underlying sex determination of murine primordial germ cells

This study uses single-nucleus multiomics to uncover gene regulatory networks and chromatin dynamics in murine PGCs during sex determination.

Dynamics of X chromosome hyper-expression and inactivation in male tissues during stick insect development

This study examines dosage compensation and meiotic sex chromosome inactivation in stick insects, finding that X chromosome expression is dynamically regulated in male tissues during development.

A conserved somatic sex determination cascade instructs trait-specific sexual dimorphism in horned dung beetles

This study investigates the somatic sex determination pathway in dung beetles, showing that RNAi targeting transformer induces male-like traits in chromosomal females, supporting conservation of some mechanisms while highlighting evolutionary divergence in others.

The basic helix-loop-helix transcription factor TCF4 recruits the Mediator Complex to activate gonadal genes and drive ovarian development

This study identifies TCF4 as a key regulator of ovarian development by recruiting the Mediator Complex to activate gonadal genes and suppress male-specific pathways.

Recent neo-X and Y sex chromosomes in an ant cricket

The paper identifies young neo-sex chromosomes in ant crickets and estimates their evolutionary origin and recombination suppression events.

Insights into the Evolution of Ancient Shark and Ray Sex Chromosomes

The paper examines sex chromosomes in 14 elasmobranch species, identifying conserved X chromosomes and a shared candidate gene for sex determination.

B cell stimulation changes the structure and higher-order organization of the inactive X chromosome

This study investigates how B cell stimulation affects the structure and organization of the inactive X chromosome, revealing dynamic changes in TAD boundaries and Xi compaction.

The transcriptomic landscape of monosomy X (45,X) during early human fetal and placental development

The paper analyzes the transcriptomic differences in 45,X tissues compared to 46,XX and 46,XY controls during early human fetal and placental development, identifying gene expression changes associated with Turner syndrome.