Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities

Heterozygosity at a conserved candidate sex determination locus is associated with female development in the clonal raider ant (Ooceraea biroi)

The paper identifies a conserved CSD locus in Ooceraea biroi where heterozygosity triggers female development, showing evolutionary conservation across ant species.

A Y-linked duplication of anti-Mullerian hormone is the sex determination gene in threespine stickleback

This paper identifies a Y-linked duplication of the anti-Mullerian hormone gene (amhy) as the primary sex determination gene in threespine stickleback, showing its necessity and sufficiency for male sex determination.

Parallel evolution of X chromosome-specific SMC complexes in two nematode lineages

This study shows that X chromosome dosage compensation mechanisms evolved independently in two nematode lineages through parallel evolution of SMC complexes.

Gonadal Transcriptome Differences Between the Sexes in Wild Caught Southern Flounder (Paralichthys lethostigma) During a Critical Development Period

This study identifies genes related to sex determination in southern flounder using transcriptome analysis of wild-caught juveniles with differing sex ratios.

A human induced pluripotent stem cell toolbox for studying sex chromosome effects

The paper generates isogenic hiPSCs with controlled sex chromosomes to study sex differences and X-haploinsufficiency effects on gene expression.

Structural and evolutionary features of red algal UV sex chromosomes

This study characterizes the U and V sex chromosomes in red algae, revealing their evolutionary origin and structural features, and highlights their role in sex determination.

Identification of a sex-determining locus potentially involved in a conflict over sex-ratio

The paper identifies a genomic region containing a gene related to male sexual differentiation in the pill bug Armadillidium vulgare, potentially involved in sex-ratio distortion.

X-chromosome upregulation operates on a gene-by-gene basis at RNA and protein levels

The paper shows that X-chromosome upregulation occurs gene-by-gene at both RNA and protein levels in mouse pluripotent stem cells.

Single cell RNA-sequencing reveals no evidence for meiotic sex chromosome inactivation in the threespine stickleback fish

The paper uses single-cell RNA-seq to show no evidence of meiotic sex chromosome inactivation in threespine stickleback fish, suggesting MSCI is not conserved in teleosts.

Reproducible autosomal gene expression changes with loss of typical X and Y complement across tumor types

The paper examines gene expression changes in tumors with altered sex chromosome complements and finds associations with poorer survival and reduced sex-based gene expression differences.

Comparative genomics of sex determination related genes reveals shared evolutionary patterns between bivalves and mammals, but not Drosophila

This study compares the sequence evolution of sex-determination related genes in bivalves, mammals, and Drosophila, finding shared patterns in bivalves and mammals but not in Drosophila.

HCFC1 and YY1 mediate recruitment of COMPASS and Integrator to initiate X chromosome inactivation.

This study identifies HCFC1 and YY1 as factors that recruit COMPASS and Integrator complexes to initiate X chromosome inactivation by regulating Xist and its cis-regulatory elements.

Gene duplication, translocation and molecular evolution of Dmrt1 and related sex-determining genes in anurans

This study investigates the evolution of sex-determining genes in anurans, finding that gene duplication is rare and sex chromosome turnover is driven by mutations in developmental pathway genes rather than translocation.

Meiotic Sex Chromosome Inactivation: conservation across the Drosophila genus

The paper investigates the evolutionary conservation of Meiotic Sex Chromosome Inactivation (MSCI) across Drosophila species by analyzing transcriptomes during spermatogenesis, revealing its role in regulating gene expression patterns.

Sex-specific transcriptome dynamics of Anopheles gambiae during embryonic development

This study maps sex-specific transcriptome dynamics in Anopheles gambiae embryos, revealing early sex-biased gene expression and dosage compensation mechanisms.

Tissue-Specific and NF-kappaB-Independent Xist RNA Localization Patterns in Female Intestinal, Blood, and Muscle Progenitors

The paper investigates Xist RNA localization patterns in female progenitor cells from different tissues, showing tissue-specific and NF-kappaB-independent mechanisms of X chromosome inactivation.

Influence of gonadal and chromosomal sex on the brain transcriptome in a mouse species with natural sex reversal

The paper compares brain transcriptomes of four sexual genotypes in African pygmy mice to show that both gonadal and chromosomal sex influence gene expression, with X*Y females showing unique patterns linked to sex-linked genes.

A Quantitative Polymerase Chain Reaction Protocol for Sex Identification of Zebra Finch and Chicken Using Blood Samples

The paper develops a quantitative PCR protocol to accurately determine the sex of zebra finches and chickens using blood samples by targeting two W chromosome loci.

Sex-biased Transcriptome in in vitro Produced Bovine Early Embryos

This study identifies sex-biased gene expression, alternative splicing, and isoform dynamics in bovine embryos, linking male-biased metabolism to faster development and female-biased X-linked gene expression to sex-specific regulation.

Genome Report: Genome of the Amazon Guppy (Poecilia bifurca) reveals conservation of sex chromosomes and dosage compensation

The paper reports the genome of the Amazon guppy, revealing conserved sex chromosomes and complete X chromosome dosage compensation despite Y chromosome degeneration.

Gene traffic mediated by transposable elements shaped the dynamic evolution of ancient sex chromosomes of varanid lizard

The paper investigates the evolution of sex chromosomes in varanid lizards, showing retrotransposons mediated gene recruitment and recombination suppression in the W chromosome.

Identification of Y-chromosome turnover in newts fails to support a sex chromosome origin for the Triturus balanced lethal system

The paper identifies the Y-chromosome in newts and finds it not homologous to the balanced lethal system, refuting a proposed sex chromosome origin for the system.

Deletion of Xist upstream sequences alters TAD interactions and leads to defects in Xist coating and expression

The paper shows that deleting Xist upstream sequences disrupts TAD organization, affects Xist expression, and leads to dysregulation of autosomal genes.

Paralog-dependent Specialization of Paf1C subunit, Ctr9, for Sex Chromosome Gene Regulation and Male Germline Differentiation in Drosophila

This study identifies Ctr9t, a testis-specific paralog of Paf1C subunit, as critical for male germline differentiation and sex chromosome gene regulation in Drosophila.

Dosage compensation and meiotic sex chromosome inactivation are maintained in the absence of selection

The paper investigates whether dosage compensation and meiotic sex chromosome inactivation persist in parthenogenetic stick insects with relaxed selection, finding both mechanisms are conserved despite the absence of male selection.

A trade-off mechanism underpins the evolution of a young two-gene sex-determining system in plants

The paper identifies two Y-linked mutations in a dioecious plant that regulate a male-female developmental trade-off through a regulatory module involving SUN, KUN, and YUN.

The gene regulatory landscape driving mouse gonadal supporting cell differentiation

The paper identifies key transcription factors and regulatory elements involved in mouse gonadal sex determination through integrated transcriptomic and chromatin accessibility analyses.

Sharks and rays have the oldest vertebrate sex chromosome with unique sex determination mechanisms

This study identifies the oldest vertebrate sex chromosomes in sharks and rays, revealing a unique dosage-dependent sex determination mechanism distinct from other vertebrates.

A whole-organism landscape of X-inactivation in humans

The paper determines X-inactivation status of 380 X-linked genes across 30 tissues in non-mosaic X-inactivation females, revealing new insights into X-inactivation and its implications for sex-bias in human traits.

An ancient X chromosomal region harbours three genes potentially controlling sex determination in Cannabis sativa

The paper identifies a locus on the X chromosome in Cannabis sativa that contains three genes potentially controlling sex determination, with distinct expression patterns across monoecious and dioecious plants.