3D Printing in Biomedical Research

STARTER : A Stand-Alone Reconfigurable and TranslationalOoC Platorm based on Modularity and Open Design Principles

The paper introduces a modular microfluidic platform for Organ-on-Chips that supports interoperability, reconfigurability, and open design to enhance collaboration and translation.

Flow-Induced Vascular Remodeling On-Chip: Implications for Anti-VEGF Therapy

This study uses a human vasculature-on-chip system to show how flow and VEGF levels affect vascular remodeling and response to anti-VEGF therapy.

Suspended Tissue Open Microfluidic Patterning (STOMP)

The paper introduces STOMP, a method to create multi-regional suspended tissues for studying complex tissue interfaces, and reports altered contractile dynamics in engineered heart tissues and bone-ligament constructs.

Structured light projection using image guide fibers for in situ photo-biofabrication

The paper introduces FaSt-Light, a fiber-based system for in situ photo-biofabrication that enables precise crosslinking of photoresins with spatial control over crosslinking chemistries and fabrication locations.

IN4MER Bioink: A Phosphorescent Biosensing Bio-ink for Multiple Analytes (Glucose, Lactate, Oxygen) Measurements and Temperature Sensing Applications

The paper introduces a phosphorescent biosensing bio-ink that enables real-time monitoring of glucose, lactate, oxygen, and temperature in 3D bioprinted constructs.

MSLASpheroidStamp: 3d cell spheroids for everyone

This paper describes a method to create agarose microwells using a 3D printer for generating 3D cell spheroids, enabling customizable and scalable production for various biological studies.

Engineered patient-derived organotypic bone model for multimodal characterization of donor-specific response to therapy

The paper develops a 3D bioprinted bone model from patient-derived cells to study donor-specific therapeutic responses to DKK1Ab in osteogenesis imperfecta.

Biofabrication of engineered tissues by 3D bioprinting of tissue specific high cell-density bioinks

This study develops tissue-specific high cell-density bioinks for 3D bioprinting, enabling the formation of multi-phase tissues with controlled architecture.

A plug-and-play transepithelial/transendothelial electric resistance (TEER)-upgraded organ-on-chip system to measure barrier dynamics in real-time

This paper introduces a plug-and-play TEER system integrated into an organ-on-chip platform for real-time barrier dynamics monitoring, showing improved sensitivity over conventional methods.

Human Colon Microphysiological System Reproducing Tissue Mechanical Microenvironment With Active Microfluidic Control and Imaging Capacity

The paper introduces a human colon microphysiological system that replicates the 3D topography and matrix stiffness of the colon using hydrogels and microfluidic control, enabling long-term culture and imaging of colonic epithelial cells.

Hybrid bioinks for embedded bioprinting of an artery model

This paper develops hybrid bioinks and an embedding bioprinting technique to create a multilayered artery model that mimics native blood vessel structure and supports cell viability.

Quantifying and modeling loss of steroid hormones in PDMS-based devices

The paper quantifies steroid hormone interactions with PDMS and models how these interactions disrupt dynamic dosing protocols in microfluidic devices.

Hypoxic-Core (HyCo) Spheroids Recapitulate Hallmarks of Clinical Hypoxia: A Simple Chip-Based Method for Translational Oncology

This paper introduces a microfluidic device to generate hypoxic-core spheroids that mimic clinical hypoxia in cancer, showing increased resistance to therapy and invasiveness.

Modeling viral and bacterial infections in human lung organotypic systems reveals strain specific host responses

This study uses human lung organoid-on-chip models to compare host responses to Streptococcus pneumoniae and SARS-CoV-2 variants, showing strain-specific infection and immune responses.

A bioprinting approach for high-throughput production of micropatterned neuroepithelial tissues and modeling TSC2-deficient brain malformations

This paper introduces a bioprinting method to create micropatterned neuroepithelial tissues that model TSC2-deficient brain malformations and enable drug screening.

3D Printed Molds for Organ-on-a-Chip and Fluidics: PDMS-Based Rapid and Accessible Prototyping

This paper introduces a method to rapidly fabricate PDMS-based organ-on-a-chip devices using 3D printing and epoxy coatings, enabling accessible and scalable microfluidic systems for biological applications.

CELLNET technology: Spatially organized, functional 3D networks at single cell resolution

The paper introduces CELLNET, a technology to generate organized 3D single-cell networks within native ECM, enabling real-time study of cell signaling and network responses to stimuli.

A data-informed approach for engineering in-vitro experiment design to decipher key features of invasive breast cancer cell phenotypes

The paper introduces a machine learning approach to analyze high-dimensional data from micro-physiological systems to identify key markers distinguishing invasive from non-invasive breast cancer cell phenotypes.

A hollow fiber membrane-based liver organoid-on-a-chip model for examining drug metabolism and transport

This paper develops a liver organoid-on-a-chip model using hollow fiber membranes to study drug metabolism and transport, showing improved hepatocyte-like maturation and functional drug processing.

Microfiber-Templated Porogel Bioinks Enable Tubular Interfaces and Microvascularization Down to the Building Blocks for 3D Bioprinting

This paper introduces a new bioink called microfiber-templated porogel (FTP) bioink that enables the creation of vascularized 3D bioprinted structures with tunable porosity and in-situ endothelialization.

In situ cell-only bioprinting of patterned prevascular tissue into bioprinted high-density stem cell-laden microgel bioinks for vascularized bone tissue regeneration

This paper develops a bioink for 3D bioprinting that enables in situ creation of vascularized bone tissue constructs in mouse calvarial defects.

Vascular network-inspired diffusible scaffolds for engineering functional neural organoids

This paper introduces VID scaffolds to enhance diffusion in neural organoids, improving their function and drug response compared to conventional organoids.

Airway smooth muscle--on-a-chip: a microfluidic approach to study alveolar smooth muscle remodelling

This paper introduces a microfluidic airway smooth muscle-on-a-chip model to study ASM remodelling and dysfunction in respiratory diseases.

Tissue Engineering Applications for Novel Integrated and Mobile Perfusion System

This paper introduces a portable perfusion system called FluidON, demonstrating its ability to maintain continuous flow, support cell viability, and enhance tissue formation through improved nutrient distribution and hydrogel strength.

A rapidly prototyped, simple yet versatile dynamic breathing Exposure-on-a-Chip for investigating nanoparticle deposition in the alveoli

The paper develops a dynamic breathing Exposure-on-a-Chip to study nanoparticle deposition in alveoli, finding that mechanical stretching reduces nanoparticle accumulation in cells.

Artery-on-chip demonstrates smooth muscle function comparable to both healthy and diseased living tissues

The paper develops an artery-on-chip model using human iPSC-derived cells to replicate arterial function and disease states, showing comparable tissue mechanics and disease phenotypes.

Autonomous control of extrusion bioprinting using convolutional neural networks

This paper develops an AI-powered extrusion bioprinting platform using CNNs for real-time quality monitoring and error correction, achieving high accuracy in classifying extrusion quality and correcting errors within 10 seconds.

Three-dimensional tissue platform co-laid with native collagen fibers and cells for phenotypic screening of stem cell interactions

This study develops a 3D tissue platform with collagen and stem cells to screen cell-cell and cell-matrix interactions, showing enhanced vascularization and identifying pathways affecting vasculogenesis and ASD models.

PHIROS: An integrated microfluidic platform for multi-day high-resolution imaging of organotypic slices

PHIROS enables long-term, high-resolution imaging of organotypic brain slices with controlled perfusion, revealing dynamic tumor-astrocyte interactions and mitochondrial transfer.

Single cell-derived spheroids for real-time growth and metabolomic studies in breast cancer

This paper develops a method to generate single cell-derived breast cancer spheroids in a decellularized matrix with plasmonic nanosensors for real-time metabolomic analysis.