Radiopharmaceutical Chemistry and Applications

SSTR2-targeted theranostics in hepatocellular carcinoma

This study evaluates SSTR2-targeted theranostics for hepatocellular carcinoma, showing SSTR2 expression and effective radioligand uptake and cytotoxicity in preclinical and clinical settings.

Localized in vivo prodrug activation using radionuclides

This paper demonstrates RAiDER, a method using radionuclides to locally activate prodrugs at tumor sites, showing significant cytotoxicity enhancement and reduced off-target effects.

Yttrium-90-doped metal-organic frameworks (MOFs) for low-dose rate intratumoral radiotherapy

This paper develops 90Y-doped MOFs for intratumoral radiotherapy, showing sustained radioisotope retention and enhanced anticancer effects in tumor models.

Radiolabeling Isolated Mitochondria with Tc-99m: A First-in-Field Protocol and Early Feasibility Findings

This paper develops a first-in-field protocol for radiolabeling isolated mitochondria with Tc-99m agents and shows early feasibility of tracking transplanted mitochondria in vivo.

In vivo tracking of ex vivo generated 89Zr-oxine labeled plasma cells by PET in a non-human primate model

The paper demonstrates a method to track ex vivo generated B cells in non-human primates using PET imaging, showing stable distribution and feasibility of repeated infusions.

Simulating Alpha Particle Doses at the Micron Scale from Prostate Cancer Patient Derived Bone Metastatic Biopsies Using GATE

The paper simulates alpha particle doses at the micron scale from prostate cancer bone metastatic biopsies using GATE to evaluate energy and dose distributions in patient-derived specimens.

Targeted Alpha Therapy with Ac-Macropa-Isatuximab for CD38-positive Hematological Malignancies

This paper evaluates [225Ac]Ac-Macropa-Isatuximab as a targeted alpha therapy for CD38-positive hematological malignancies, showing significant tumor reduction and survival extension with minimal toxicity.

Engineered Nanobodies Bind Theranostic Main Group Metals

This paper shows that mutating nanobodies to create cysteine motifs enables specific binding of theranostic metals like bismuth, gallium, and indium for medical imaging and therapy.

Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

This paper develops a mathematical model to optimize targeted radionuclide therapy for multiple myeloma by identifying key principles for improving treatment efficacy while minimizing toxicity.

Advantage of the F(ab)'2 fragment over IgG for RIT and PRIT

This paper compares the therapeutic index of IgG and F(ab)2 fragments in preclinical radioimmunotherapy models, finding F(ab)2 improves therapeutic outcomes.

In vivo imaging of T-cell coregulator B7-H4 reveals protumor macrophage status in prostate cancer

This paper develops an immunoPET tracer to visualize B7-H4 in prostate cancer models, showing its ability to detect tumor-associated B7-H4 and macrophage status.

Synthesis of K+ channel radioligand 5-methyl-3-fluoro-4-aminopyridine and PET imaging in mice

This paper synthesizes [18F]5Me3F4AP, a K+ channel PET radioligand, and demonstrates its brain uptake and kinetics in mice, suggesting it as a potential improved tracer for demyelination imaging.

Exploring the PET in vivo generator 134Ce as a theranostic match for 225Ac

This paper compares 225Ac and 134Ce-labeled tracers in cancer models to assess their suitability as a theranostic pair, finding that 134Ce's PET imaging is limited by daughter nuclide redistribution.

A general approach to reduce off-target radioactivity in vivo via Tetrazine-Knock-Out (TKO)

This paper develops a method to rapidly clear radioactivity from blood using a tetrazine-knock-out (TKO) approach, improving imaging contrast and reducing radiation exposure.

Radiosynthesis automation, non-human primate biodistribution and dosimetry of K+ channel tracer 3MeO4AP

The paper develops an automated radiosynthesis protocol for [11C]3MeO4AP and evaluates its biodistribution and dosimetry in non-human primates.

Evaluation of trans- and cis-4-fluorogabapentin for brain PET imaging

This study evaluates two fluorinated gabapentin derivatives for brain PET imaging of 2{delta} receptors in rhesus macaques, showing differential brain uptake and displacement characteristics.

Detection of IL23p40 via Positron Emission Tomography Visualized Inflammatory Bowel Disease

This study demonstrates that immunoPET targeting IL23p40 can detect inflammation in a mouse model of IBD, offering a potential non-invasive diagnostic approach.

Radiochemical Synthesis and Evaluation of 3-methyl-4-aminopyridine in Rodents and Non-Human Primates for Imaging Potassium Channels in the CNS

The paper describes the synthesis and evaluation of [11C]3Me4AP, a tracer for imaging Kv1 channels in the CNS, showing lower brain uptake and slower kinetics compared to related tracers.

High-Contrast PET imaging with -NT160, a Class-IIa Histone Deacetylase (Class-IIa HDAC) Probe for In Vivo Imaging of Epigenetic Machinery in the Central Nervous System

This paper develops [18F]-NT160, a PET tracer for imaging class-IIa HDACs in the brain, showing high-contrast imaging and specific uptake patterns across brain regions.

Antigen-dependent inducible T cell reporter system for PET imaging of breast cancer and glioblastoma

This paper develops a PET imaging system using engineered T cells that report antigen recognition through inducible reporter gene expression, showing enhanced signal in antigen-expressing tumors.

Development of a PET radioligand for α2δ-1 subunit of calcium channels for imaging neuropathic pain

This paper develops two 18F-labeled gabapentin derivatives for imaging the α2δ-1 subunit of calcium channels in neuropathic pain, showing increased uptake in injured nerves.

Design, synthesis, and characterization of mG2P026 as a high contrast PET imaging ligand for metabotropic glutamate receptor 2

The paper describes the synthesis and characterization of [18F]mG2P026 as a PET ligand for mGluR2, showing improved brain permeability and binding compared to existing compounds.

Synthesis and characterization of 5-(2-fluoro-4-pyridine-7-carboxamide as a PET imaging ligand for metabotropic glutamate receptor 2

The paper develops and characterizes [11C]13, a PET ligand for mGluR2, showing its brain distribution and response to mGluR2 NAMs in rats and nonhuman primates.

A metabolically stable PET tracer for imaging synaptic vesicle protein 2A: Synthesis and preclinical characterization of SDM-16

This paper develops and evaluates [18F]SDM-16, a metabolically stable SV2A PET tracer, showing high affinity and specific binding in nonhuman primate brains.

Synthesis and preclinical evaluation of MTP38 as a novel PET ligand for phophodiesterase 7 in the brain

This paper develops [11C]MTP38 as a PET ligand for PDE7 and demonstrates its preclinical success in imaging PDE7 in the brain.

Radiochemical synthesis and evaluation in nonhuman primates of 3-methoxy-4-aminopyridine: a novel PET tracer for imaging potassium channels in the CNS

This paper develops and evaluates [11C]3MeO4AP, a PET tracer for imaging potassium channels in the CNS, showing high brain permeability, metabolic stability, and sensitivity to brain injury.