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Exposure to deceased remains of conspecifics extends the lifespan of young and aged C. elegans via distinct pathways

This study shows that exposure to lysed C. elegans remains extends lifespan via distinct pathways in young and aged worms, independent of ascaroside pheromones or bacterial lysates.

Caenorhabditis elegans avoids Todstoff, a novel nociceptive necrotaxis cue

This study identifies Todstoff, a novel aversive cue in C. elegans that induces necrotaxis behaviors by signaling through ASH neurons and GPCR pathways.

Estimation of effective size of large continuously distributed populations

The paper estimates the effective population size (Ne) of a large, structured population using linkage disequilibrium, finding much higher Ne values than previously reported for maritime pine.

Histone H3 availability is more important for development than H3.2 versus H3.3 subtype identity

This study shows that availability of histone H3 is more critical for development than the specific subtype (H3.2 vs H3.3) in Drosophila.

Integrating Enviromics to Predict Performance and Guide Clonal Deployment in Eucalyptus spp.

This paper develops an enviromic framework to predict tree performance and guide clonal deployment in Eucalyptus spp., achieving higher accuracy than traditional GxE models.

Beyond thresholds: a fully Bayesian framework for quantifying allele count evidence for variant pathogenicity

This paper introduces a Bayesian framework to quantify allele count evidence for variant pathogenicity using Bayes factors, showing compatibility with existing criteria while allowing tunable parameters.

Comprehensive Variant Effect Map of Parkin-Mediated Mitophagy in Parkinson's Disease

This paper maps the functional effects of Parkin variants in mitophagy, distinguishing pathogenic from benign variants with high accuracy.

Functional characterization of the 9q34.13 locus identifies RAPGEF1 as modulating risk for melanoma and nevi via RAS activation

This study identifies RAPGEF1 as a gene modulating melanoma and nevi risk through RAS activation, using fine-mapping, expression data, and functional assays.

Stemness factor Mex3a times translation and protein trafficking to ensure robust differentiation of olfactory sensory neurons

This study shows that Mex3a regulates neuronal differentiation by controlling translation and trafficking of cell surface proteins, cilia structure, and planar cell polarity in olfactory sensory neurons.

The conserved N-terminal SANT1-binding domain (SBD) of EZH2 Regulates PRC2 Activity

This study investigates how the conserved SBD of EZH2 regulates PRC2 activity, showing its necessity for histone methylation and cancer cell proliferation.

A Functional Genetic Atlas of Parkin Resolves Variants of Uncertain Significance and Predicts Parkinson's Disease Age at Onset

The paper functionally characterizes PRKN variants using a pooled assay, reclassifies variants of uncertain significance, and predicts Parkinson's disease age at onset.

Ammonium Transporters Govern Nutrient Sensing and Trap Induction in the Nematode-Trapping Fungi Arthrobotrys oligospora

This study identifies ammonium transporters in Arthrobotrys oligospora that regulate trap induction under nitrogen limitation, without affecting trap morphology or function.

A distributive germline restricts the spread of new mutations

The paper shows that multiple early-diverged cell lineages in maize germline reduce mutation recurrence without changing the mutation rate.

Genetic impacts on within-pair DNA methylation variance in monozygotic twins capture gene-environment interactions and cell-type effects

The paper identifies vmeQTLs for blood DNA methylation variance in MZ twins, showing gene-environment interactions and cell-type effects relevant to immune disease.

A reference panel for linkage disequilibrium and genotype imputation using whole-genome sequencing data from 2,680 participants across India

The paper constructs a large-scale LD and genotype imputation reference panel using whole-genome sequencing data from 2,680 Indian participants, improving imputation accuracy and polygenic risk score performance.

Platform-dependent effects of genetic variants on plasma APOL1

The paper identifies platform-dependent effects of APOL1 variants on plasma levels measured by different proteomic technologies.

Whole-genome sequencing analysis of anthropometric traits in 672,976 individuals reveals convergence between rare and common genetic associations

This study uses whole-genome sequencing in 672,976 individuals to show rare and common variants converge in genetic associations for anthropometric traits, with ultra-rare variants explaining less than 10% of heritability.

Assessment of segregation variance estimates from derivation, simulations, and empirical data in autotetraploid species exemplified in potato

The paper derives algebraic methods to predict segregation variance in autotetraploid species, compares them with simulations and empirical data, and finds they correlate well with simulations but not with empirical data due to small family sizes.

Practical utility of sequence-to-omics models for improving the reproducibility of genetic fine-mapping

This study evaluates sequence-to-omics models to improve reproducibility in genetic fine-mapping across eQTL datasets, showing reduced replication failure rates and enhanced SNP prioritization.

Assessing target genes for homing suppression gene drive

This study evaluates CRISPR-based homing gene drives targeting female fertility genes in Drosophila to suppress population growth, finding varying efficiency and fitness costs across targets.