A. Lee

Glioblastoma remodeling of neural circuits in the human brain decreases survival

This study shows glioblastomas alter neural circuits in the human brain, reducing survival and impairing cognition through synaptogenic interactions.

GRP78 binds SARS-CoV-2 Spike protein and ACE2 and GRP78 depleting antibody blocks viral entry and infection in vitro

Lipid-based, protein-based, and steric interactions synergize to facilitate transmembrane signaling stimulated by antigen-clustering of IgE receptors

This study investigates how lipid-based, protein-based, and steric interactions synergize to enable transmembrane signaling in mast cells through Ag-crosslinking of IgE-FcεRI.

Decoding the Protein Composition of Whole Nucleosomes with Nuc-MS

The paper introduces Nuc-MS, a method to analyze protein composition of whole nucleosomes, revealing specific histone variants and modifications associated with oncogenic states.

Disulfiram inhibits M. tuberculosis growth by altering methionine pool, redox status and host-immune response

This study identifies disulfiram as a novel inhibitor of Mtb's methionine biosynthesis, showing anti-tubercular effects through redox disruption and immune modulation.

Metformin enhances anti-mycobacterial responses by educating immunometabolic circuits of CD8+ T cells

This study shows metformin improves anti-mycobacterial responses by enhancing metabolic and functional properties of CD8+ T cells in mice and humans.

The Atlas of the In Vivo HIV CD4 T Cell Reservoir

The paper develops a method to trace latently-infected HIV CD4 T cells to their original states using CyTOF, revealing the reservoir's conserved yet tissue-specific composition and enabling isolation of unstimulated latent cells.

Dynamic Loading of Human Engineered Heart Tissue Enhances Contractile Function and Drives Desmosome-linked Disease Phenotype

The paper develops a dynamic EHT model to enhance contractile function and study desmosome-linked disease phenotypes in engineered heart tissues.

Bradycardic mice undergo effective heart rate improvement after specific homing to the sino-atrial node and differentiation of adult muscle derived stem cells.

This study shows that adult muscle-derived stem cells can differentiate into cardiac pacemaker cells and improve heart rate in bradycardic mice.

The quorum-sensing systems of Vibrio campbellii DS40M4 and BB120 are genetically and functionally distinct

This paper compares the quorum-sensing systems of Vibrio campbellii DS40M4 and BB120, finding genetic and functional differences in autoinducer production, regulatory mechanisms, and regulon size.

Within and cross species predictions of plant specialized metabolism genes using transfer learning

The paper uses transfer learning to predict specialized metabolism genes in tomato by leveraging annotations from Arabidopsis thaliana, improving prediction accuracy.

Evaluation of Dose Fractionated Polymyxin B on Acute Kidney Injury: A Translational In Vivo Model

This study evaluates the effect of fractionated polymyxin B dosing on acute kidney injury in rats, finding that thrice-daily dosing caused the most kidney damage.

Marizomib suppresses triple-negative breast cancer via proteasome and oxidative phosphorylation inhibition

Marizomib inhibits primary tumor growth and reduces lung and brain metastases in pre-clinical triple-negative breast cancer models.

Histone acetylome-wide association study of tuberculosis

This study conducts a histone acetylome-wide association study (HAWAS) of tuberculosis, identifying differentially acetylated loci and their association with immune phenotypes.

High-resolution and high-accuracy topographic and transcriptional maps of the nucleosome barrier

The paper maps nucleosome barriers' topography and Pol II dynamics using single-molecule assays and reveals how H2A.Z and uH2B modify barrier height and width, affecting transcription.

A putative enoyl-CoA hydratase contributes to biofilm formation and the antibiotic tolerance of Achromobacter xylosoxidans

This study identifies a putative enoyl-CoA hydratase involved in biofilm formation and antibiotic tolerance in Achromobacter xylosoxidans using a transposon mutagenesis approach.

Aging induces Nlrp3 inflammasome dependent adipose B cell expansion to impair metabolic homeostasis

This study shows aging increases adipose B cells and FALCs via Nlrp3 inflammasome, impairing metabolism, and B cell depletion improves metabolic function in aged mice.

Aerodigestive sampling reveals altered microbial exchange between lung, oropharyngeal, and gastric microbiomes in children with impaired swallow function

This study examines microbial exchange between lung, oropharyngeal, and gastric microbiomes in children with impaired swallow function, finding increased similarity between lung and oropharyngeal microbiomes in those with aspiration.

Reproductive success of Eastern Bluebirds (Sialia sialis) varies with the timing and severity of drought

This study examines how drought timing and severity impact Eastern Bluebird reproductive success using citizen science and climate data.

Systematic Discovery of the Functional Impact of Somatic Genome Alterations in Individual Tumors through Tumor-specific Causal Inference

This paper introduces a tumor-specific causal inference framework to identify causative somatic genome alterations and their impact on molecular phenotypes in individual tumors.

MFF-dependent mitochondrial fission regulates presynaptic release and axon branching by limiting axonal mitochondria size

This study shows that MFF-dependent mitochondrial fission limits axonal mitochondria size, which affects presynaptic release and axon branching by altering Ca2+ uptake capacity.