A. Sette

Immunological memory to SARS-CoV-2 assessed for up to eight months after infection

The paper assesses SARS-CoV-2 immune memory components over eight months post-infection, finding varying kinetics in antibodies, B cells, and T cells.

Antigen-specific induction of CD4+CD8αα+ intraepithelial T lymphocytes byBacteroidetes species

This study identifies Bacteroidetes species that induce CD4+CD8αα+ intraepithelial T lymphocytes, which provide protective immunity against colitis.

PD-1 blockade exacerbates Mycobacterium tuberculosis infection in rhesus macaques

This study shows that PD-1 blockade worsens Mycobacterium tuberculosis infection in rhesus macaques by increasing bacterial loads and altering immune responses.

Identification and characterization of CD4+ T cell epitopes after Shingrix vaccination.

This study identifies and characterizes CD4+ T cell epitopes specific to Shingrix vaccination, showing a shift in immunodominance from non-structural proteins to gE and mapping HLA restrictions for these epitopes.

Comparison of HLA ligand elution data and binding predictions reveals varying prediction performance for the multiple motifs recognized by HLA-DQ2.5

This study compares HLA ligand elution data with binding predictions for HLA-DQ2.5, finding discrepancies due to ambiguous MHC restriction and underprediction of certain peptides.

Single-cell transcriptomic analysis of SARS-CoV-2 reactive CD4+ T cells

This study analyzes single-cell transcriptomes of SARS-CoV-2 reactive CD4+ T cells in COVID-19 patients, finding differences in cell types and gene expression between severe and mild disease.

Generation of a novel SARS-CoV-2 sub-genomic RNA due to the R203K/G204R variant in nucleocapsid: homologous recombination has potential to change SARS-CoV-2 at both protein and RNA level

The paper identifies a novel SARS-CoV-2 sub-genomic RNA generated by homologous recombination involving the R203K/G204R variant in nucleocapsid, which may enhance viral adaptation and expression.

An Effective CTL Peptide Vaccine for Ebola Zaire Based on Survivors' CD8+ Targeting of a Particular Nucleocapsid Protein Epitope with Potential Implications for COVID-19 Vaccine Design

The paper identifies a conserved Ebola Zaire epitope that provides protection in mice and suggests its potential application in COVID-19 vaccine design.

Candidate targets for immune responses to 2019-Novel Coronavirus (nCoV): sequence homology- and bioinformatic-based predictions

The paper identifies potential immune targets for 2019-nCoV using sequence homology and bioinformatic predictions.

The challenge of distinguishing cell-cell complexes from singlet cells in non-imaging flow cytometry and single-cell sorting

The paper identifies molecular signatures and methods to distinguish cell-cell complexes from singlet cells in flow cytometry data, highlighting their impact on data interpretation.

T cell responses induced by attenuated flavivirus vaccination are specific and show limited cross-reactivity with other flavivirus species.

This study shows that T cell responses to flavivirus vaccines are specific and have limited cross-reactivity with other flavivirus species.

Limited recognition of Mycobacterium tuberculosis-infected macrophages by polyclonal CD4 and CD8 T cells from the lungs of infected mice

The paper assesses T cell recognition of Mtb-infected macrophages in mice and finds that CD4 T cells more effectively recognize these cells than CD8 T cells, with BCG vaccination eliciting such responses.

Benchmarking predictions of MHC class I restricted T cell epitopes

This study benchmarks T cell epitope prediction tools using a comprehensive dataset of vaccinia virus epitopes, finding that neural network-based methods trained on MHC binding and ligand elution data perform best.

A Modified Injector and Sample Acquisition Protocol Can Improve Data Quality and Reduce Inter-Instrument Variability of the Helios Mass Cytometer

The paper describes a modified Helios mass cytometer protocol that improves data quality and reduces inter-instrument variability in multi-center studies.

No cell is an island: circulating T cell:monocyte complexes are markers of immune perturbations

The paper identifies T cell:monocyte complexes in human blood as biological immune interactions, not technical artifacts, and shows their frequency changes with immune perturbations.

Immuno-proteomic interrogation of dengue infection reveals novel HLA haplotype-specific MHC-I antigens

This study identifies novel MHC-I antigens specific to dengue virus infection using an immuno-proteomics approach, revealing ligands associated with distinct HLA haplotypes and T-cell recognition.

Footprints of antigen processing boost MHC class II natural ligand binding predictions

This study develops MHC class II ligand binding predictors trained on naturally eluted peptides, showing improved performance by incorporating antigen processing rules.

Evidence that recurrent Group A streptococcus tonsillitis is animmunosusceptibility disease involving antibody deficiency and aberrant Tfh cells

The paper investigates recurrent Group A Streptococcus tonsillitis and finds it involves antibody deficiency and aberrant Tfh cells, with genetic factors contributing to susceptibility.