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Transmembrane protein KIRREL1 regulates Hippo signaling via a feedback loop and represents a potential therapeutic target in YAP/TAZ-active cancers

The effector protein CgNLP1 of Colletotrichum gloeosporioides from Hevea brasiliensis disrupts nuclear localization of necrosis-induced transcription factor HbMYB8-like to suppress plant defense signaling

Single-Cell Transcriptomic Analyses of Tumor Ecosystems and Spatial Architectures in Human Small Cell Lung Cancers

This study uses single-cell and spatial transcriptomics to analyze heterogeneity and immunosuppressive microenvironment in human SCLC, identifying hybrid tumor cell states and their origins.

Three amphioxus reference genomes reveal gene and chromosome evolution of chordates

This study presents three amphioxus reference genomes, revealing insights into chordate gene and chromosome evolution, including WGDs, chromatin architecture, and sex chromosome dynamics.

Transcriptomics analysis reveals intracellular mutual regulation of coral-zooxanthella holobionts

The paper analyzes transcriptomes and small RNAs of corals and their symbionts to reveal mutual gene regulation mechanisms and miRNA roles in host-symbiont interactions.

Structures of the human cholecystokinin receptors in complex with agonists and antagonists

The paper reports crystal and cryo-EM structures of human CCKAR and CCKBR with ligands, revealing ligand recognition and activation mechanisms.

The METTL5-TRMT112 N6-methyladenosine methyltransferase complex regulates metabolism and development via translation

This paper identifies the METTL5-TRMT112 complex as the methyltransferase responsible for m6A modification at 18S rRNA, linking it to metabolism and development.

Broad neutralization against SARS-CoV-2 variants induced by a modified B.1.351 protein-based COVID-19 vaccine candidate

This study evaluates a modified B.1.351 spike trimer vaccine candidate, showing it induces broad neutralization against multiple SARS-CoV-2 variants in mice.

Ultrapotent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants

This study identifies three ultrapotent SARS-CoV-2 neutralizing antibodies effective against B.1.351 variants, showing synergistic effects and protective efficacy in mice.

High-Throughput and High-Dimensional Single Cell Analysis of Antigen-Specific CD8+ T cells

This study introduces TetTCR-SeqHD, a method to profile antigen-specific CD8+ T cells, revealing unique phenotypes and cross-reactive TCRs in type 1 diabetes.

Patterns of gene content and co-occurrence constrain the evolutionary path toward animal association in CPR bacteria

This study examines gene content and co-occurrence patterns in CPR bacteria to understand their evolutionary transitions between environmental and animal-associated habitats.

Spatial modulation of individual behaviors enables collective decision-making during bacterial group migration

The paper studies bacterial group migration and finds that spatially modulated individual behaviors enable coherent collective movement without complex computation.

Bacterium-Enabled Transient Gene Activation by Artificial Transcription Factor for Resolving Gene Regulation in Maize

The paper uses synthetic TAL effectors delivered by bacteria to activate the maize gene gl3, revealing its role in cuticular wax biosynthesis and identifying downstream genes involved in this process.

The Prognostic Value of Tumor-Infiltrating Immune Cells in Gynecologic Cancers

This study characterizes immune infiltration patterns in ovarian, cervical, and uterine cancers and identifies immune subtypes associated with prognosis.

Phosphorylation of the selective autophagy receptor TAX1BP1 by canonical and noncanonical IκB kinases promotes its lysosomal localization and clearance of MAVS aggregates

This study shows that phosphorylation of TAX1BP1 by IκB kinases promotes its lysosomal degradation and enhances its ability to clear MAVS aggregates.

Patient-Derived Orthotopic Xenografts and Cell Lines from Pediatric High-Grade Glioma Recapitulate the Heterogeneity of Histopathology, Molecular Signatures, and Drug Response

The paper establishes patient-derived orthotopic xenograft models and cell lines from pediatric high-grade glioma that replicate histopathology, molecular signatures, and drug response, providing a resource for research.

Light spectra modify nitrogen assimilation and nitrogen content in Quercus variabilis Blume seedling components: A bioassay with 15N pulses

This study examines how different light spectra affect nitrogen assimilation and content in Quercus variabilis seedlings under nitrogen pulses.

Controlling Cellular Arrangements via Stretched Bioprinting

This paper introduces a bioprinting method that controls cellular orientation through stretching, enabling aligned myofiber formation and effective tissue repair in vivo.

Characterization of LC-MS based urine metabolomics in healthy subjects across the life span

This study characterizes urine metabolomics across the lifespan in healthy individuals, identifying age- and gender-specific metabolic patterns and pathway enrichments.

N6-methyladenosine modification of HIV-1 RNA evades RIG-I-mediated sensing to suppresses type-I interferon induction in monocytic cells

This study shows that HIV-1 RNA's m6A modifications suppress type-I interferon induction in monocytic cells by evading RIG-I sensing.

Tethering-facilitated DNA 'opening' and complementary roles of β-hairpin motifs in the Rad4/XPC DNA damage sensor protein

This study shows Rad4/XPC can open undamaged DNA in solution without specific β-hairpin motifs and reveals dynamic conformations of open DNA through crystal structures and fluorescence analysis.

A key linear epitope for a potent neutralizing antibody to SARS-CoV-2 S-RBD

This study identifies a linear epitope on SARS-CoV-2 S-RBD recognized by a potent neutralizing antibody and shows its potential for vaccine design.

A rapid and efficient screening system for neutralizing antibodies and its application for the discovery of potent neutralizing antibodies to SARS-CoV-2 S-RBD

This paper introduces a rapid screening system to identify potent neutralizing antibodies against SARS-CoV-2 and demonstrates its effectiveness in discovering high-potency antibodies.

Targeted Genome Editing of Bacteria Within Microbial Communities

This paper develops a method to edit specific bacteria within microbial communities using ET-Seq and DART systems, enabling genetic manipulation in complex environments.

Groundwater Elusimicrobia are metabolically diverse compared to gut microbiome Elusimicrobia and some have a novel nitrogenase paralog

The paper analyzes genomes of Elusimicrobia from various environments, finding groundwater-associated species show diverse metabolic capabilities and some encode novel nitrogenase paralogs.

Scaled Recoupling of Chemical Shift Anisotropies at High Magnetic Fields under MAS with Interspersed C-elements

This paper introduces a new NMR pulse sequence, fROCSA, to measure chemical shift anisotropies for carbonyl groups in solid-state NMR by modifying scaling factors with interspersed C-elements.

Human IgG neutralizing monoclonal antibodies block SARS-CoV-2 infection

This study identifies potent human neutralizing antibodies against SARS-CoV-2 from convalescent patients, with some showing high efficacy in blocking viral entry.

Fecal microbiota transplantation reconstructs the gut microbiota of septic mice and protects the intestinal mucosal barrier

This study shows that fecal microbiota transplantation (FMT) restores gut microbiota balance and protects the intestinal barrier in septic mice by enhancing short-chain fatty acid production.

Impact of DNA sequences in the DNA duplex opening by the Rad4/XPC nucleotide excision repair complex

This study shows that DNA sequences affect how Rad4/XPC opens DNA duplexes, with some sequences resisting opening despite prolonged Rad4 binding.

H. pylori infection inhibits autophagy to aggravate DNA damage by p62-mediated Rad51 ubiquitination

This study shows H. pylori infection inhibits autophagy, leading to DNA damage via p62-mediated Rad51 ubiquitination in gastric cells.