F. Yang

Differences in Activation of Intracellular Signalling in Primary Human Retinal Endothelial Cells Between Isoforms of VEGFA-165.

This study compares the activation of MAPK and AKT signaling pathways by VEGFA165a and VEGFA165b in primary human retinal endothelial cells, finding stronger activation by VEGFA165a at lower doses.

Ferroptosis contributes to developmental cell death in rice blast

This study identifies ferroptosis as a key developmental cell death mechanism in the rice blast fungus, showing its role in pathogenic growth and host invasion.

Stable integrant-specific differences in bimodal HIV-1 expression patterns revealed by high-throughput analysis

The paper tracks HIV-1 proviral clones over time in polyclonal populations, revealing stable, clone-specific expression patterns and clonal expansion dynamics independent of cell-type or metabolic factors.

Changes in the expression of interleukin-10 in myocardial infarction and its relationship with macrophage activation and cell apoptosis

This study examines changes in IL-10 expression in myocardial infarction and its association with macrophage activation and cardiomyocyte apoptosis over time.

Integrated Low-Energy and Low Carbon Shortcut Nitrogen removal with Biological Phosphorus Removal for Sustainable Mainstream Wastewater Treatment

The paper demonstrates efficient combined nitrogen, phosphorus, and chemical oxygen demand removal in a wastewater treatment system using anaerobic-aerobic cycling and nitritation-denitritation without exogenous chemicals.

A novel xenograft model of human HCC in immunocompetent mouse

This paper establishes a novel human HCC patient-derived xenograft model in immunocompetent mice, showing high tumor formation rates and preserved tumor characteristics.

PIRD: Pan immune repertoire database

PIRD is a database that collects and stores annotated TCR and BCR sequencing data, along with tools for visualization and analysis.

Age-related changes to macrophages are detrimental to fracture healing

This study shows that age-related changes in macrophages impair fracture healing in old mice, and depleting these macrophages improves healing outcomes.

The glycine locating at random coil of picornaviruses VP3 enhances viral pathogenicity by targeting p53 to promote apoptosis and autophagy

This study shows that the Gly129 residue in FMDV-VP3 enhances viral pathogenicity by promoting apoptosis and autophagy through p53 interaction, and this residue is conserved across picornaviruses.

Distinct gut metagenomics and metaproteomics signatures in prediabetics and treatment-naïve type 2 diabetics

The paper compares gut metagenomics and metaproteomics in prediabetics and treatment-naïve type 2 diabetics to identify host-microbial interplays across disease stages.

High Genetic Potential for Proteolytic Decomposition in Northern Peatland Ecosystems

The paper assesses microbial genetic potential for organic nitrogen depolymerization in northern peatlands, finding bacterial protease genes dominate over nitrogen-fixing genes.

Mitochondrial dynamics and mitophagy are necessary for proper invasive growth in Rice Blast

This study shows that mitochondrial dynamics and mitophagy are essential for the invasive growth of Magnaporthe oryzae during rice blast disease.

Plasma Circular RNA Panel to Diagnose Hepatitis B Virus-Related Hepatocellular Carcinoma

This study identifies a plasma circular RNA panel with higher diagnostic accuracy than AFP for detecting HBV-related hepatocellular carcinoma.

Functional linkage of gene fusions to cancer cell fitness assessed by pharmacological and CRISPR/Cas9 screening

The paper functionally links gene fusions to cancer cell fitness using drug sensitivity and CRISPR-Cas9 data, identifying rare functional fusions and novel therapeutic targets.

The third-generation tetracycline, KBP-7072, exploits and reveals a new potential of the primary tetracycline binding pocket

This study determines the structure of KBP-7072 bound to the 30S ribosomal subunit, showing it inhibits protein synthesis by binding to the primary tetracycline site and interacting uniquely with the subunit.

Comammox Nitrospira are the dominant ammonia oxidizers in a mainstream low dissolved oxygen nitrification reactor

This study shows comammox Nitrospira dominate ammonia oxidation in a low dissolved oxygen nitrification reactor, outperforming conventional systems.

Proteomic Profile of TGF-β1 treated Lung Fibroblasts identifies Novel Markers of Activated Fibroblasts in the Silica Exposed Rat Lung

The paper identifies 196 differentially expressed proteins in TGF-β1-treated lung fibroblasts and finds that VLDLR and SDC2 are upregulated in silica-exposed lungs, with knockdown reducing collagen production.

Aerobic removal of microcystin-LR by a novel native effective bacterial community designated as YFMCD4 isolated from Lake Taihu

This study identifies a bacterial community YFMCD4 that effectively removes microcystin-LR from water, with degradation rates influenced by temperature, pH, and concentration.

ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks

The paper identifies how ATM counteracts toxic non-homologous end-joining at broken replication forks by showing that loss of NHEJ components or BRCA1-A complex confers resistance to DNA-damaging agents in ATM-deficient cells.

Molecular mechanisms controlling the multistage post-translational processing of endogenous Nrf1α/TCF11 proteins to yield distinct proteoforms within the coupled positive and negative feedback circuits

This study identifies the molecular mechanisms and post-translational modifications governing the generation of distinct Nrf1α/TCF11 proteoforms and their involvement in feedback circuits with regulatory proteins.

SlARF10, an auxin response factor, is required for chlorophyll and sugar accumulation during tomato fruit development

This study shows SlARF10 regulates chlorophyll and sugar accumulation in tomato fruits by controlling starch synthesis and photosynthesis.

A lncRNA/Lin28/Let7 Axis Coupled To DNA Methylation Fine Tunes The Dynamics Of A Cell State Transition

The paper identifies a lncRNA/miRNA/DNA methylation axis that regulates the timing of stem cell state transition from naive pluripotency.