F. Yang

Life on the leaf: Seasonal activities of the phyllosphere microbiome of perennial crops

This study analyzes the seasonal activities of the phyllosphere microbiome in switchgrass and miscanthus using metagenome and metatranscriptome sequencing to identify key microbial functions and their responses to environmental cues.

Fungal jasmonate as a novel morphogenetic signal for pathogenesis

This study identifies a fungal oxylipin analogous to jasmonic acid as a morphogenetic signal that triggers pathogenic development in Magnaporthe oryzae by interacting with cyclic AMP and redox signaling.

Single cell transcriptome analysis of decidua macrophages in normal and recurrent spontaneous abortion patients

The paper profiles single-cell transcriptomes of decidual macrophages in normal and recurrent spontaneous abortion patients, identifying distinct polarization states and potential therapeutic targets.

Structure of SOQ1 lumenal domains identifies potential disulfide exchange for negative regulation of photoprotection, qH

This study reports the crystal structures and biochemical characterization of SOQ1 lumenal domains, revealing their structural organization and potential regulatory mechanisms in suppressing qH.

Molecular basis for SPINDOC-Spindlin1 engagement and its role in transcriptional inhibition

This paper identifies the molecular mechanism by which SPIN*DOC inhibits Spindlin1's transcriptional coactivator activity through multivalent binding and competitive inhibition.

S-Trimer, a COVID-19 subunit vaccine candidate, induces protective immunity in nonhuman primates

This study evaluates S-Trimer, a subunit vaccine candidate for COVID-19, showing it induces protective immunity in nonhuman primates with adjuvants.

Soil causes gut microbiota to flourish and total serum IgE levels to decrease in mice

The study shows that soil intake in mice increases gut microbial diversity and reduces serum IgE levels, suggesting potential prebiotic effects.

Autonomous sensing the insulin peptide by an olfactory G protein coupled receptor modulates glucose metabolism

The paper identifies Olfr109 as an olfactory receptor that detects insulin peptides in pancreatic β cells, modulating glucose metabolism and inflammation.

Shared B cell memory to coronaviruses and other pathogens varies in human age groups and tissues

The paper examines age-related differences in B cell memory to coronaviruses and other pathogens across tissues and age groups, finding higher frequencies of class-switched memory B cells in children.

Collagen induced inflammations

This paper describes a protocol for inducing collagen-induced arthritis (CIA) in mice using bovine collagen type II and Freund's adjuvants, and reports associated enteritis and arthritis outcomes.

An improved comprehensive strategy for deep and quantitative N-glycomics based on optimization of sample preparation, isotope-based data quality control and quantification, new N-glycan libraries and new algorithms

The paper presents an improved strategy for deep N-glycomics with optimized sample prep, isotope-based QC, new libraries, and algorithms, but the manuscript was withdrawn due to incomplete data.

Increased light availability enhances tolerance against ocean acidification stress in Halimeda opuntia

Increased light availability enhances stress resistance in Halimeda opuntia by the accumulation of soluble organic molecules and enzyme-driven activities to alleviate ocean acidification stress.

Oncogenic Activation of AKT by MAPK6

This study shows that MAPK6 activates AKT to promote cancer, leading to oncogenic outcomes and poor patient survival in multiple cancers.

Integrative proteomic and phosphoproteomic analysis of granulosa cells during follicular atresia in porcine

This study identifies differentially expressed proteins and phosphosites in porcine granulosa cells during follicular atresia, revealing potential biomarkers and pathways involved in the process.

Qualitative and quantitative bioanalytical methods validation of aristolochic acid DNA adducts and application in human formalin-fixed paraffin-embedded hepatocellular carcinoma tissues

This paper validates a method to quantify aristolochic acid DNA adducts in human tissues and applies it to hepatocellular carcinoma samples, finding a low prevalence of adducts.

In-cell destabilization of a homo-dimeric protein complex detected by DEER spectroscopy

This study uses DEER spectroscopy to show that a homo-dimeric protein complex is destabilized in human cells compared to solution, challenging excluded volume crowding theory.

A valid protective immune response elicited in rhesus macaques by an inactivated vaccine is capable of defending against SARS-CoV-2 infection

This study shows an inactivated SARS-CoV-2 vaccine induces neutralizing antibodies and CTL responses in rhesus macaques, effectively preventing viral replication and lung inflammation.

Structure of human sodium leak channel NALCN in complex with FAM155A

The paper reports the cryo-EM structure of human NALCN with FAM155A, revealing interactions and ion-binding sites that inform Na+ permeation and disease mechanisms.

An Antioxidant Enzyme Therapeutic for COVID-19

This paper describes a catalase-based therapeutic for COVID-19 that reduces oxidative stress and cytokine production in human and animal models without toxicity.

SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damage and constitutes an antiviral target

This study shows the SARS-CoV-2 envelope protein causes ARDS-like damage and identifies channel inhibitors as potential antiviral targets.

Post-translational control of PlsB is sufficient to coordinate membrane synthesis with growth in Escherichia coli

This study identifies PlsB as the key enzyme regulating membrane phospholipid synthesis in E. coli, showing its post-translational control coordinates membrane production with growth.

Structural basis of bile acid receptor activation and Gs coupling

The paper reports cryo-EM structures of GPBAR-Gs complexes, revealing structural features of bile acid recognition, allosteric effects, and biased signaling.

PIWIL1 Promotes Gastric Cancer via a piRNA-Independent Mechanism

This paper shows PIWIL1 promotes gastric cancer independently of piRNA by interacting with the NMD pathway.

Lamin B2 follows lamin A/C- mediated nuclear mechanics and cancer cell invasion efficacy

The paper investigates the role of lamin B2 in nuclear mechanics and cancer cell invasion, finding that lamin B2 cooperates with lamin A/C to regulate nuclear deformability and migration efficacy.

In Vivo Efficacy and PK/PD Modeling of KBP-7072, An Aminomethylcycline Antibiotic, in Neutropenic Pneumonia and Thigh Infection Models

This study evaluates the in vivo efficacy and PK/PD of KBP-7072, an aminomethylcycline antibiotic, in pneumonia and thigh infection models, showing significant dose-dependent reductions in CFUs and improved survival.

Consistency of superb microvascular imaging and contrast enhanced ultrasonography in detecting intraplaque neovascularization: a meta-analysis

This meta-analysis compares the consistency of superb microvascular imaging and contrast-enhanced ultrasonography in detecting intraplaque neovascularization, finding a high Kappa index indicating good agreement.

A transferrable and interpretable multiple instance learning model for microsatellite instability prediction based on histopathology images

This paper develops a transferable and interpretable deep learning model for MSI prediction from histopathology images, achieving high AUC scores in two cohorts.

Polyploidization enhancing genetic recombination of the ancestral diploid genome in the evolution of hexaploid wheat

This study shows that hexaploidization in wheat enhances genetic recombination of the ancestral diploid genome, increasing evolutionary potential and aiding wheat's global spread.

Targeting Aryl Hydrocarbon Receptor with small molecule, 1'H-indole-3'-carbonyl -thiazole-4-carboxylic acid methyl ester blocked human glioma cell invasion via MYH9

The paper shows that ITE, an AHR ligand, inhibits glioma cell migration and invasion by reducing MYH9 expression, which is critical for cell motility.

An unorthodox mechanism underlying voltage sensitivity of TRPV1 ion channel

This study identifies an unconventional voltage-sensing mechanism in TRPV1 channels where outer pore acidic residues, not the S4 segment, mediate voltage sensitivity and activation.