J. Jiang

Maxent modeling for predicting the potential distribution of global talaromycosis

This paper uses Maxent modeling to predict the global distribution of talaromycosis, identifying key environmental and epidemiological drivers.

Generation of a microsporidia species attribute database and analysis of the extensive ecological and phenotypic diversity of microsporidia

The paper creates a database of 1,440 microsporidia species and analyzes their ecological and phenotypic diversity, finding broad host ranges and polar tube length as a determinant of tissue specificity.

Talaromyces marneffei promotes M2 polarization of human macrophages by downregulating SOCS3 expression and activating TLR9 pathway

This study shows Talaromyces marneffei induces M2 macrophage polarization by downregulating SOCS3 and activating TLR9, enhancing fungal survival.

Self-assembling SARS-CoV-2 nanoparticle vaccines targeting the S protein induces protective immunity in mice

This study develops self-assembling SARS-CoV-2 nanoparticle vaccines that induce protective immunity in mice through subcutaneous and oral administration.

Synthetic nanobody-SARS-CoV-2 receptor-binding domain structures identify distinct epitopes

The paper reports X-ray structures of synthetic nanobodies bound to SARS-CoV-2 RBD, revealing CDR loop interactions and epitope recognition details.

Coupling of H3K27me3 recognition with transcriptional repression through the BAH-PHD-CPL2 complex in Arabidopsis

The paper identifies a mechanism by which H3K27me3 is recognized and transcriptionally repressed through the BAH-PHD-CPL2 complex in Arabidopsis.

Representations of local spatial information in the human medial temporal lobe duringmemory-guided navigation

This study uses fMRI to examine how the human hippocampus and medial temporal lobe represent spatial and reward information during memory-guided navigation.

Stretch and Twist of HEAT Repeats Leads to Activation of DNA-PK Kinase

The paper reports cryoEM structures of DNA-PKcs in inactive and activated forms, revealing structural changes in HEAT repeats that drive kinase activation.

Antagonistic crosstalk fine-tunes sensitivities of IRE1 and PERK signaling during unfolded protein response

The paper studies how IRE1 and PERK signaling branches coordinate during ER stress, finding mutual inhibition and differential sensitivity regulated by p58IPK.

Indole acetic acid and lipopeptide-producing endophytic bacteria from Taxus chinesis: toxicity evaluation of metabolic products

The paper screens endophytic bacteria from Taxus chinensis for IAA and lipopeptide production, identifies non-toxic strains, and suggests their potential for biofertilizer use.

An automatic and efficient pulmonary nodule detection system based on multi-model ensemble

This paper presents a CAD system for pulmonary nodule detection that improves recall, reduces false positives, and optimizes time consumption using a multi-model ensemble approach.

Structural Insight into Mitochondrial Beta-Barrel Outer Membrane Protein Biogenesis

The paper reports cryoEM structures of the mitochondrial SAM complex from Myceliophthora thermophila, revealing its architecture and mechanism for substrate accommodation.

Senescent stromal cells promote cancer resistance through SIRT1 loss-potentiated overproduction of small extracellular vesicles

This study shows senescent stromal cells release sEVs that promote cancer drug resistance via SIRT1 loss, and suggests targeting SIRT1 could prevent this resistance.

Substrate deformation regulates DRM2-mediated DNA methylation in plants

This study identifies DNA deformation as a mechanism regulating DRM2-mediated methylation specificity in plants, showing how substrate deformation influences substrate preference.

Prostaglandin receptor EP2 is a novel molecular target for high-risk neuroblastoma

This study identifies EP2 as a key PGE2 receptor promoting neuroblastoma growth and shows that targeting it with small-molecule antagonists inhibits tumor growth in mice.

Combinatorial effect of miR-486-5p & miR-22-3p mimics thrombopoietin's impact on hematopoietic stem & progenitor cells

The paper identifies miR-486-5p and miR-22-3p as drivers of megakaryocytic differentiation in HSPCs without thrombopoietin, and shows MkMPs induce this through JNK and PI3K/Akt/mTOR signaling.

Microbial grazers may aid in controlling infections caused by aquatic zoosporic fungi

The paper evaluates how micrograzers control chytrid infections in amphibians by modeling their grazing impact on zoospores.

Retrograde induction of phyB orchestrates ethylene-auxin hierarchy to regulate growth

The paper shows MEcPP coordinates auxin and ethylene signaling via phytochrome B to regulate hypocotyl growth in response to light.

Sucrose promotes etiolated stem branching through activation of cytokinin accumulation followed by vacuolar invertase activity

This study shows sucrose promotes potato stem branching by increasing cytokinin levels and vacuolar invertase activity in lateral buds.

Active monomer RTR-1 derived from the root of Rhodomyrtus tomentosa induces apoptosis in gastric carcinoma cells by inducing ER stress and inhibiting the STAT3 signalling pathway

This study shows RTR-1, a compound from Rhodomyrtus tomentosa, inhibits gastric cancer cell proliferation by inducing ER stress and blocking the STAT3 pathway, while causing G2/M phase cell cycle arrest.

Prevalence of beta-lactam drug-resistance genes in commensal Escherichia coli contaminating ready-to-eat lettuce

This study found that a significant proportion of E. coli isolates from ready-to-eat lettuce in Northern California carry beta-lactam resistance genes, posing a potential risk for human infections.

Evolutionary changes of phosphoenolpyruvate transporter (PPT) during the emergence of C4 photosynthesis

This study examines evolutionary changes in the phosphoenolpyruvate transporter (PPT) during C4 photosynthesis emergence, identifying shifts in expression, light responsiveness, and cis-element acquisition in PPT1.

Targeting the Cx43 Carboxyl Terminal H2 Domain Preserves Left Ventricular Function Following Ischemia-Reperfusion Injury

This paper identifies that CT1's interaction with Cx43's carboxyl terminal H2 domain, not ZO-1, mediates its protective effects against ischemia-reperfusion injury in the heart.

Wolbachia pipientis occurs in Aedes aegypti populations in New Mexico and Florida, USA

The study detects Wolbachia in wild Ae. aegypti mosquitoes from New Mexico and Florida, but not in Texas, and identifies the wAlbB strain.

Changes in the Physicochemical Properties and Microbial Communities of Rhizospheric Soil after Cassava/Peanut Intercropping

This study examines how cassava/peanut intercropping affects rhizospheric soil physicochemical properties and microbial communities, finding improved nutrient content, pH, and microbial diversity.

A cellular census of healthy lung and asthmatic airway wall identifies novel cell states in health and disease

The paper uses single-cell transcriptomics to identify novel cell states in healthy and asthmatic lung tissues, revealing changes in cell communication and immune responses.

A simple method to co-purify genomic DNA, RNA, and proteins for functional studies

This paper introduces a simple method to co-purify genomic DNA, RNA, and proteins from the same samples, reducing precipitation steps and enabling high-throughput analyses.

Comparative evidence for the independent evolution of hair and sweat gland traits in primates

The paper compares hair follicle and eccrine sweat gland density across macaques, chimpanzees, and humans, finding humans have lower hair density and higher sweat gland density than other primates.

Hemolysin liberates bacterial outer membrane vesicles for cytosolic lipopolysaccharide sensing

This study shows hemolysin facilitates cytosolic LPS sensing by liberating bacterial outer membrane vesicles, leading to inflammasome activation and gut inflammation.

Gene markers for exon capture and phylogenomics in ray-finned fishes

The paper identifies and validates single-copy gene markers for phylogenomic studies in ray-finned fishes using comparative genomics and empirical testing across 83 species.