J. Jiang

Zinc Fingers and Homeoboxes 2 is Required for Diethylnitrosamine-induced Liver Tumor Formation in C57BL/6 Mice

This study shows that Zhx2 acts as an oncogene in a liver tumor model, contradicting previous findings in human cell lines and other models, and correlates with higher ZHX2 expression in HCC patients.

Asparagine starvation suppresses histone demethylation through iron depletion

This study shows asparagine starvation reduces histone demethylation by depleting labile iron, which is essential for JHDMs function, and this effect is mediated through IREB2 and TFRC regulation.

Novel Viroid-like RNAs Naturally Infect a Filamentous Fungus

The paper identifies novel viroid-like circular RNAs in a fungal host, showing they replicate autonomously and modulate host biology, suggesting a new class of viroid-like entities in fungi.

Prevalent regulation of GATA2/3 and MSX2 on endogenous retrovirus-derived regulatory elements in human trophoblast stem cells

This study identifies GATA2/3 and MSX2 as key regulators of ERV-derived enhancers in human trophoblast stem cells, revealing their role in placental gene regulation.

YAP antagonizes TEAD-mediated AR signaling and prostate cancer growth

This study shows YAP suppresses AR-driven prostate cancer growth by blocking TEAD-mediated AR signaling through competitive binding.

Machine learning reveals conserved chromatin patterns determining meiotic recombination sites in plants

The paper uses machine learning to identify key chromatin features that determine meiotic recombination sites in plants, finding that three features can predict crossover sites with 90% accuracy.

Talaromyces marneffei suppresses human macrophages inflammatory by producing the truncated protein NCOR2-013 via TUT1-regulated alternative splicing

This study identifies TUT1-regulated alternative splicing of NCOR2 producing NCOR2-013 as a mechanism by which Talaromyces marneffei suppresses macrophage inflammation.

Tracing back primed resistance in cancer via sister cells

The paper introduces ReSisTrace, a method to identify pre-resistant cell states in cancer by analyzing sister cells, and validates its use in ovarian cancer models.

Rapid Regulation of Local Temperature and TRPV1 Ion Channels with Wide-Field Plasmonic Thermal Microscopy

This paper introduces wide-field plasmonic thermal microscopy (W-PTM) for rapid local temperature regulation and demonstrates its use in modulating TRPV1 ion channels in living cells.

Covalent Disruptor of YAP-TEAD Association Suppresses Defective Hippo Signaling

This paper develops a covalent inhibitor of the YAP-TEAD complex, demonstrating its ability to suppress Hippo signaling defects and inhibit cancer cell growth.

Hypomorphism of a novel long ERα isoform causes severe reproductive dysfunctions in female mice

This study identifies a novel long ERα isoform enriched in female reproductive tissues and shows its critical role in reproductive function in female mice.

Development and evaluation of a loop-mediated isothermal amplification (LAMP) method for detection of the potato wart pathogen Synchytrium endobioticum

The paper develops and evaluates a LAMP method for detecting the potato wart pathogen Synchytrium endobioticum, showing it is sensitive, specific, and suitable for routine lab testing.

AFM Microfluidic Cantilevers as Weight Sensors for Single Cell Mass Measurements

This paper introduces microfluidic cantilevers for single-cell mass measurement, achieving sub-nanogram sensitivity and demonstrating improved performance with polymer materials.

Single-Objective Evanescent Scattering Microscopy for Imaging Single Proteins and Binding Kinetics

This paper introduces single-objective evanescent scattering microscopy for label-free single protein imaging and binding kinetics quantification with high spatiotemporal resolution.

Hedgehogs are the major amplifying hosts of severe fever with thrombocytopenia syndrome virus

This study identifies hedgehogs as the major amplifying hosts of SFTSV, showing they can sustain viral transmission cycles with ticks in both laboratory and natural settings.

Targeted photothrombotic stroke leads to disruptions in neurovascular coupling

This study investigates how photothrombotic stroke disrupts neurovascular coupling and shows that acute recovery of this coupling predicts sensorimotor function recovery.

Chromatin reprogramming and transcriptional regulation orchestrate embryogenesis in hexaploid wheat

This study maps chromatin reprogramming and transcriptional regulation during hexaploid wheat embryogenesis, revealing epigenetic mechanisms governing cell fate and organogenesis.

The Flowering Repressor SVP recruits the TOPLESS co-repressor to control flowering in chrysanthemum and Arabidopsis

This study shows that SVP interacts with TPL to repress flowering by inhibiting FT gene expression in chrysanthemum and Arabidopsis, highlighting a conserved mechanism across species.

Re-entry into mitosis and regeneration of intestinal stem cells through enteroblast dedifferentiation in Drosophila midguts

This study shows that enteroblasts in Drosophila midguts re-enter mitosis and dedifferentiate into intestinal stem cells via EGFR-Ras signaling, revealing a mechanism for tissue regeneration.

Identification of diverse viruses associated with grasshoppers unveils phylogenetic congruence between hosts and viruses

This study identifies 322 viruses in 34 grasshopper species, including 202 novel species, and finds phylogenetic congruence between grasshoppers and certain viral families.

Connexin Hemichannels with Prostaglandin Release in Anabolic Function of Bone to Mechanical Loading

The paper shows that osteocytic Cx43 hemichannels mediate bone anabolic responses to mechanical loading via PGE2 release, and identifies them as a potential therapeutic target for bone loss.

Structure of the Shaker Kv channel and mechanism of slow C-type inactivation

The paper determines the structure of the Shaker Kv channel and reveals that slow C-type inactivation involves dilation of the selectivity filter.

STAYGREEN-mediated chlorophyll a catabolism is critical for photosystem stability upon heat stress in ryegrass

This study shows that suppressing Chl a catabolism in ryegrass reduces heat tolerance by disrupting photosystem stability, ROS balance, and chloroplast structure under moderate heat stress.

Aphid transmission of a Potexvirus, Foxtail mosaic virus, in the presence of the Potyvirus helper component proteinase

This study shows that adding specific DAG motifs from potyviruses to non-aphid transmissible potexviruses can confer aphid transmission capabilities, with varying efficiency depending on the motif and host plant.

A NOVEL PREGNANT RAT MODEL FOR LABOR INDUCTION AND AUGMENTATION WITH OXYTOCIN

This paper develops a rat model for oxytocin-induced labor and evaluates its effects on maternal and neonatal outcomes, finding no evidence of oxidative stress in the newborn brain.

Inactivation effects of plasma-activated water on Fusarium graminearum

This study investigates how plasma-activated water (PAW) affects the viability and cellular responses of Fusarium graminearum, finding significant inhibition of microbial activity and damage to cell wall, membrane, and mitochondria.

TMEM120A contains a specific coenzyme A-binding site and might not mediate poking- or stretch-induced channel activities in cells

This study shows TMEM120A does not mediate poking- or stretch-induced currents and identifies a specific coenzyme A-binding site through cryo-EM structures.

CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 variants

This study shows that CD147 antibody inhibits SARS-CoV-2 infection and cytokine storm in variants by blocking viral entry and reducing inflammatory responses.

KDM4 Orchestrates Epigenomic Remodeling of Senescent Cells and Potentiates the Senescence-Associated Secretory Phenotype

This study shows KDM4 promotes epigenomic changes in senescent cells, enhances the SASP, and presents a therapeutic target for age-related diseases.

Reduced virulence and enhanced host adaption during antibiotics therapy: A story of a within-host carbapenem-resistant Klebsiella pneumoniae sequence type 11 evolution in a fatal scrotal abscess patient

This study tracks the genomic evolution of ST11-CRKP during antibiotic therapy in a patient, identifying mutations linked to reduced virulence and increased host adaptation.