K. Chen

Impairment of autophagy-lysosomal activity near the chronically implanted microelectrodes

This study investigates how long-term microelectrode implantation impairs autophagy-lysosomal activity, leading to tissue degeneration near the implant.

Deciphering deep-sea chemosynthetic symbiosis by single-nucleus RNA-sequencing

This study uses single-nucleus RNA sequencing to create a cell atlas of deep-sea mussel gills, revealing cell types and their roles in supporting chemosynthetic symbiosis and environmental adaptation.

Spatially-resolved single-cell atlas of ascidian endostyle provides insights into the origin of vertebrate pharyngeal organs

The paper constructs a spatially-resolved single-cell atlas of the ascidian endostyle, identifying new cell types and evolutionary insights into vertebrate pharyngeal organs.

Learning from the expert: studying Salicornia to understand salinity tolerance

This study identifies genes and proteins in Salicornia bigelovii that contribute to salinity tolerance, with potential applications for improving crop resilience.

MmcA is an electron conduit that facilitates both intracellular and extracellular electron transport in Methanosarcina acetivorans

This study identifies MmcA as an electron conduit in Methanosarcina acetivorans that supports both methanogenesis and dissimilatory metal reduction.

Lead (Pb) Inhibits-PMA Induced Microglia Multinucleation

This study investigates how lead exposure affects PMA-induced multinucleation in microglia, finding that lead inhibits multinucleation by inducing multinuclear regression.

Piezo inhibition prevents and rescues scarring by targeting the adipocyte to fibroblast transition

This study shows that inhibiting Piezo1 or Piezo2 prevents adipocyte-to-fibroblast transition, reducing scarring in wounds and suggesting a therapeutic target for fibrosis.

Phage administration with repeated intravenous doses leads to faster phage clearance in mammalian hosts

This study evaluates phage clearance and host responses to repeated intravenous phage doses in rats and monkeys, finding faster clearance and immune activation with repeated administration.

An efficient stochastic steering strategy of magnetic particles in vascular networks

This paper develops a multi-physics model and stochastic magnetic steering strategy to enhance drug particle mobility and navigation in vascular networks.

Single-cell transcriptomic analyses reveal the cellular and genetic basis of aquatic locomotion in scyphozoan jellyfish

The paper was withdrawn due to the need for additional experimental evidence and reorganization of data and writing.

The Alfin-like transcription factor GmAlfin09 regulates endoplasmic reticulum stress in soybean via a peroxidase GmPRDX6

This study identifies GmAlfin09 as a transcription factor that enhances ER stress resistance in soybean by upregulating GmPRDX6, which reduces ROS levels and maintains ER homeostasis.

Differential CpG methylation at Nnat in the early establishment of beta cell heterogeneity

This study identifies differential CpG methylation at the Nnat gene as a mechanism establishing beta cell heterogeneity during development and its potential role in diabetes.

Single-molecule displacement mapping unveils sign-asymmetric protein charge effects on intraorganellar diffusion

The paper uses single-molecule displacement mapping to show that positive charges impede protein diffusion in organelles, while negative charges do not, with an exception in the ER protein PPIB.

An efficient context-aware approach for whole slide image classification

The paper introduces WIT, a context-aware transformer model for whole slide image classification, achieving higher accuracy than baseline methods across multiple cancer datasets.

ATP-releasing SWELL1 channel in spinal microglia contributes to neuropathic pain

This study identifies VRAC as an ATP-releasing channel in microglia contributing to neuropathic pain and shows dicumarol inhibits it, reducing pain behaviors in mice.

Structure of the ISW1a complex bound to the dinucleosome

The paper reports the cryoEM structure of the ISW1a complex bound to the dinucleosome, revealing its mechanism of nucleosome spacing and organization.

Androgen-mediated TGFβ expression suppresses anti-tumor neutrophil response in bone metastatic prostate cancer

This study identifies androgen-mediated TGFβ expression as a mechanism suppressing anti-tumor neutrophil response in bone metastatic prostate cancer and shows that combining ADT with TGFβ receptor inhibition restores neutrophil cytotoxicity.

A high-throughput COPD bronchosphere model for disease-relevant phenotypic compound screening

This paper develops a high-throughput bronchosphere model for COPD and screens compounds to identify those that reverse CSE-induced phenotypic changes.

Spatial Localization Ability of Planarians Identified Through the Light Maze Paradigm

This paper demonstrates that planarians can navigate to a previously recognized location in a new maze, indicating they have spatial localization ability.

Multi-omics of Circular RNAs and Their Responses to Hormones in Moso Bamboo (Phyllostachys edulis)

This study identifies and characterizes circRNAs in moso bamboo, their biogenesis, function, and response to gibberellins and auxins.

Spatially Multiplexed Single-molecule Translocations through a Nanopore at Controlled Speeds

This paper introduces a method to control single-molecule translocations through a nanopore with spatial and temporal precision, achieving high-resolution DNA analysis.

Improved Genome Editing by an Engineered CRISPR-Cas12a

This paper improves CRISPR-Cas12a genome editing by combining rational engineering and directed evolution to enhance homology-directed repair efficiency.

Integrated single-cell functional and molecular profiling of extracellular vesicle secretion in metastatic breast cancer

The paper identifies a four-gene signature associated with EV secretion in breast cancer and links it to poor prognosis and immune evasion.

A comprehensive single-cell breast tumor atlas defines cancer epithelial and immune cell heterogeneity and interactions predicting anti-PD-1 therapy response

The paper defines cancer epithelial and immune cell heterogeneity in breast tumors using single-cell RNA-seq and develops a tool to predict anti-PD-1 therapy response.

Structure of the NuA4 acetyltransferase complex bound to the nucleosome

This study reports the cryo-EM structure of the NuA4 complex bound to a nucleosome, revealing its mechanism of nucleosome recognition and transcription coactivation.

In vivo spatiotemporal dynamics of astrocyte reactivity following neural electrode implantation

This study uses two-photon microscopy to observe astrocyte reactivity in mouse brains after intracortical microelectrode implantation, revealing distinct spatiotemporal dynamics compared to other glial cells.

Disruptive selection via pollinators and seed predators on the height of flowers in a wind-dispersed alpine herb

The paper examines how pollinators and seed predators influence selection on floral stalk height in Pulsatilla alpina, finding disruptive selection and positive effects on reproductive success.

High-density and scalable protein arrays for single-molecule proteomic studies

This paper develops a scalable method to create dense single-molecule protein arrays using DNA origami and surface functionalization, enabling high-sensitivity proteomic analysis.

Sugar transporter Slc37a2 regulates bone metabolism via a dynamic tubular lysosomal network in osteoclasts

This study identifies Slc37a2 as a sugar transporter in osteoclast secretory lysosomes, showing its role in bone metabolism through dynamic tubular networks and its impact on bone mass.

The Modular μSiM: a Mass Produced, Rapidly Assembled, and Reconfigurable Platform for the Study of Barrier Tissue Models In Vitro

The paper introduces a modular, mass-produced tissue chip platform for barrier tissue models, validated for blood-brain barrier studies and reconfigurable for other applications.