Gut microbiota and health

Exploring the role of multivariate associations between brain networks and gut microbiota in (food) value-based decision-making

The paper uses a supervised method to integrate gut microbiota and brain network data, identifying a multimodal component linked to food valuation and choice in a healthy population.

Cannabinoid receptor 1 activity promotes microbial dysbiosis by stimulating the oxygen-dependent expansion of Enterobacteriaceae

This study shows that CB1 receptor activation promotes microbial dysbiosis by stimulating oxygen-dependent expansion of Enterobacteriaceae, leading to exacerbated colitis.

Dietary omega-3 polyunsaturated fatty acids interact with select gut microbes to produce bioactive metabolites found in infant gut metabolomes

The paper identifies gut microbial interactions with omega-3 fatty acids that produce bioactive metabolites present in infant gut metabolomes.

Ethnic differences in gut microbiota composition and functional capacity persist over six years in the HELIUS multi-ethnic longitudinal cohort

The paper tracks ethnic differences in gut microbiota composition and function over six years in a multi-ethnic cohort, finding persistent disparities despite shared environment.

BioMeBar Indian Gut Reference Atlas: A Harmonised Multi-Cohort Healthy Microbiome Baseline and the Indian Gut Health Index

The paper harmonizes Indian gut microbiome cohorts to create a reference atlas and the Indian Gut Health Index, revealing geographic and cohort-specific microbial patterns.

Decision-relevant measurement for precision microbiome interventions

The paper evaluates how well microbiome measurements from different intestinal regions predict intervention decisions compared to stool samples.

Mechanistic prediction of fecal microbiota transplant engraftment and Clostridioides difficile colonization resistance with μODE

This paper introduces muODE, a framework that simulates microbial community dynamics using metagenomics data to predict FMT outcomes and C. difficile resistance.

Microbial Invasion and Immunosuppression Drives Adenoma Progression in Early Colorectal Cancer Development

The paper shows bacterial invasion and neutrophil immunosuppression drive adenoma progression in a porcine FAP model using single-cell RNA sequencing and spatial transcriptomics.

Chronic stress remodels gut bacterial ecology and polysaccharide metabolism with neuroendocrine consequences despite unchanged behavior

This study shows chronic stress alters gut bacterial function and metabolism, affecting neuroendocrine pathways without changing behavior in mice.

Urban Vietnam at the microbiome transition: Co-existing enterotypes reflect the global industrialization patterns

The paper analyzes gut microbiome data from Vietnamese adults to show two enterotypes reflecting industrialization stages, similar to global patterns.

Bacterial dispersal and host specificity shape microbiome strain sharing among great ape species in neighboring zoo exhibits

This study examines microbiome strain sharing among zoo-housed great apes, finding that phylogenetic structure persists despite shared environments and that spore-forming bacteria may drive cross-exhibit transmission.

Variation in gut microbiome diversity and structure across host lifestyles in Thailand

This study examines gut microbiome diversity and structure across different lifestyles in Thailand, finding variations in microbial composition and associations with lifestyle factors.

SpiE is a distinct gut microbial 4-cholesten-3-one 5β-reductase that acts with SpiR to convert cholesterol to coprostanol

The paper identifies SpiE as a gut microbial enzyme that, along with SpiR, converts cholesterol to coprostanol, and shows its correlation with stool coprostanol levels and antibiotic impact.

Fu Ling (Wolfiporia cocos) Fungal β-Glucan in Combination with Bacillus coagulans Improve Colitis-Related Outcomes and Cecal Fermentation in DSS-Treated Mice

This study shows that a combination of fungal β-glucan and Bacillus coagulans reduces colitis symptoms and improves gut health in DSS-treated mice.

Pharmacological Effects and Candidate Bioactive Constituents of Huanglian Wendan Decoction in Experimental Metabolic Syndrome: Multi-Omics Analysis of Gut-Liver Metabolism and NLRP3 Signaling

This study evaluates the effects of Huanglian Wendan Decoction on metabolic syndrome using multi-omics analysis, identifying its impact on gut-liver metabolism and NLRP3 signaling, with baicalin as a candidate bioactive constituent.

Peripheral microbial metabolites as indicators of gut microbiome disruption: systematic review and meta-analysis

This study identifies peripheral microbial metabolites as indicators of gut microbiome disruption, showing they can distinguish microbiome states with performance comparable to direct sequencing.

Prehistoric Global Migration of Vanishing Gut Microbes With Humans

The paper compares gut microbiomes of Tsimane and Hadza populations to show that many microbes co-migrated with humans globally, but are now vanishing in industrialized populations.

Quantifying the Resource Landscape That Shapes the Human Gut Microbiome

The paper maps resource fluxes into the human gut using diet and digestion data, finding carbon and phosphorus limitations for microbial growth and highlighting microbial contributions to cobamide pools.

Gut microbiota-derived indole-3-propionic acid preserves dorsal hippocampal catecholamines to prevent post-stroke cognitive impairment

This study identifies indole-3-propionic acid (IPA) as a gut microbiota-derived metabolite that prevents post-stroke cognitive impairment by preserving catecholamines in the dorsal hippocampus.

Measurement-Induced Decision Loss: A feasible-set theory of microbiome intervention under observation loss

Measurement-induced decision loss (MIDL), host benefit forgone versus perfect observation, grows linearly with microbiome information loss in a binary model, then plateaus once the optimal policy becomes signal-independent.

Diet-conditioned microbiota enhances fecal microbiota transplantation efficacy in alcoholic liver disease through caproic acid-PPARα signaling

This study shows that a high-protein donor diet enhances fecal microbiota transplantation efficacy in alcoholic liver disease by increasing caproic acid and PPARα signaling.

Sex-Dependent Microbiome-Metabolome Remodeling Associated with Bacteroides acidifaciens Modulation of Acute Respiratory Distress Syndrome

This study investigates sex-dependent microbiome and metabolome changes in mice with ARDS induced by Bacteroides acidifaciens, finding distinct metabolic and microbial responses in males and females.

Dissecting functional dynamics of fecal-derived in vitro stable microbial communities with metaproteomics

This study uses metaproteomics to analyze how culture medium and donor-specific factors influence the establishment of in vitro fecal microbial communities over time.

A microbiota-dependent gut bile acid axis links germline mutant p53 to distal tumour growth.

This study shows that mutant p53 alters gut microbiota interactions, leading to bile acid changes that promote distal tumour growth.

LGTM: Gaussian Process Modulated Neural Topic Modeling for Longitudinal Microbiome

LGTM couples a neural topic model with additive basis-function Gaussian processes, learning microbial co-abundance topics and how covariates relate to their trajectories in longitudinal gut microbiome data.

Paired sequencing of IgA-bound bacteria reveals widespread associations between adaptive immunity and gut microbiome gene expression.

The paper introduces PIg-seq to study IgA-bound bacteria and finds widespread transcriptional responses, including changes in conjugation genes and prophages, linking IgA to horizontal gene transfer.

Community-wide adaptive evolution of gut bacteria during dietary transitions

This study shows that dietary transitions drive reproducible adaptive evolution in gut bacteria across multiple species, with specific genetic responses observed in key functions like invertases.

Effects of CO2 on the growth and metabolism of Akkermansia muciniphila

This study investigates how CO2 affects the growth and metabolism of Akkermansia muciniphila, showing increased growth and metabolic changes under CO2 exposure.

Accurate detection of metagenomic strain-level associations using average nucleotide identity with StrainSpy

StrainSpy fits zero-inflated beta mixed models to containment ANI, reaching >98% simulated sensitivity versus ~79% for logistic regression and detecting colorectal-cancer E. coli strain shifts.

Gut Microbiota Fuel Aging Induced by Mitochondrial Dysfunction

This study shows mitochondrial dysfunction accelerates aging by disrupting gut microbiota structure and inducing immune dysregulation and inflammation through metabolic reprogramming.