Alzheimer's disease research and treatments

The paper shows that pathological tau activates NF-κB in microglia and that a pT181-Qβ vaccine reduces NF-κB activity in tauopathy mice.

This study develops a serum-free murine astrocyte culture to investigate ER stress and inflammation in response to amyloid-beta, showing enhanced ER stress and inflammatory responses under specific conditions.

The paper uses a computational model to show neuronal activity and amyloid-beta drive tau seeding in the entorhinal cortex, linking these factors to early Alzheimer's disease pathology.

The paper introduces a programmable self-assembling protein system to model intracellular protein aggregation in neurodegenerative diseases and reveals disease-specific aggregate-organelle interactions.

The paper demonstrates that Fe65 links APP to Arf6 and RhoGTPases to regulate macropinocytosis, which is critical for Aβ production in Alzheimer's disease.

This study shows that Arf6 and RhoGTPases Rac1, Cdc42, and RhoA are required for macropinocytosis of Aβ42 oligomers and tau fibrils in neurons, suggesting new targets to prevent their transfer in Alzheimer's disease.

CRB-2131, an NADPH oxidase inhibitor, reduces tauopathy and neuroinflammation in Alzheimer's disease models, improving cognition and neuronal health.

This study shows that lysosomal exocytosis releases amyloid beta from hiPSC-derived neurons, suggesting it as a therapeutic target for Alzheimer's disease.

This study shows that formaldehyde exposure increases Aβ40, Aβ42, and phosphorylated tau levels in 3D-cultured human neural cells, suggesting a role in Alzheimer's disease initiation and progression.

This paper investigates the link between low choline levels, obesity, metabolic dysfunction, and neuropathology in humans and 3xTg-AD mice, finding sex-specific and obesity-related associations.

The paper identifies a novel astrocyte state linked to cognitive decline in Alzheimer's disease and validates its regulators through multi-modal analysis and mechanistic experiments.

This study investigates how AT8 phosphorylation affects Tau protein conformation and dynamics using biophysical experiments and simulations.

The paper identifies shared molecular mechanisms between Alzheimer's and Parkinson's disease by analyzing gene co-expression at sub-cell-type resolution using single-nucleus datasets.

This study compares the efficacy of single-chain variable fragments (scFvs) targeting different tau epitopes in reducing cerebral tau in transgenic mice, finding that scFv-MC1 monotherapy is more effective than combination therapy.

The paper shows that synaptotoxic forms of amyloid-beta and alpha-synuclein act through the same Wnt/PCP pathway to cause dendritic spine loss in neurodegenerative diseases.

The paper identifies genetic variants associated with protein abundance and altered protein-protein correlations in the Gyrus Temporalis Medius in Alzheimer's Disease patients.

This study identifies gene-diet interactions that influence cognitive resilience to Alzheimer's disease in mice, finding a diet-dependent genetic locus associated with resilience.

This study uses synergistic MAPT mutations to create a model for tau aggregation, identifying Hsp70 as a key driver and showing its impact on neuronal function.

The paper analyzes the OTULIN interactome in PS19 transgenic and non-transgenic mice to identify proteins involved in immune response and autophagy associated with tauopathy.

This study uses single molecule microscopy to show that tau condensate ageing involves liquid-solid coexistence at the fibril level, with spatial heterogeneity driving the transition.

This study investigates how inhibiting disulphide bonding in truncated tau affects its self-assembly into seed-competent structures, revealing enhanced aggregation rates and implications for tauopathy research.

This paper develops a protein-like polymer that inhibits tau fibril propagation in human-derived models of neurodegeneration by targeting a specific structural motif of 4R tau isoforms.

This study investigates polyamine biosynthesis dysregulation in Alzheimer's disease and Down syndrome models, finding that DFMO reduces Aβ42 aggregation and AD-related protein levels in DS fibroblasts.

This study shows that impaired astrocyte stress response to amyloid-beta activates delta secretase, leading to amyloid and tau pathologies in Alzheimer's disease.

DARG provides a database of Alzheimer-related genes in model organisms, enabling users to search human genes, find orthologs, and access expression and phenotype data in Drosophila.

This study shows that APOE3 and APOE4 human astrocytes differentially affect Alzheimer's disease hallmarks in chimeric mice, with APOE3 reducing and APOE4 worsening pathology.

This study shows that alpha-Synuclein co-pathology in Alzheimer's Disease increases tau levels, linking AD and Parkinson's Disease pathogenesis.

The paper investigates how exogenous amyloid sequences from gut microbiota affect Aβ heterotypic aggregation and introduces the 'Interaction History' concept.

This study examines TTR levels and instability in plasma and CSF across AD stages, finding associations with amyloid-beta, tau, and neuroinflammation markers.