Antifungal resistance and susceptibility

Macrophage vacuolar ATPase (v-ATPase) function controls Aspergillus fumigatus germination and hyphal growth independent of spore killing

Structure-activity Relationship for Diarylpyrazoles as Inhibitors of the Fungal Kinase Yck2

The paper identifies structure-activity relationships for diarylpyrazole inhibitors of the fungal kinase Yck2, showing improved selectivity and antifungal activity.

Unveiling Cell Wall Structure and Echinocandin Response in Candida auris and Candida albicans via Solid-State NMR

This study uses solid-state NMR to analyze how echinocandin treatment alters cell wall structures in Candida auris and Candida albicans, revealing structural changes linked to drug resistance.

Monitoring Candida albicans Biofilm Formation by Impedance Using Passive RFID

This study shows that C. albicans biofilm formation alters dielectric properties, which can be monitored using passive RFID for biofilm detection.

Combined genetic and environmental factors shape the landscape of anti-fungal tolerance in Nakaseomyces glabratus

This study quantifies antifungal drug tolerance in Nakaseomyces glabratus and shows it is influenced by both genetic and environmental factors.

Polygenetic Determinants of Azole Resistance, Tolerance, and Heteroresistance in Candida albicans

This study identifies polygenic determinants of fluconazole susceptibility, tolerance, and heteroresistance in Candida albicans using GWAS on 557 isolates, revealing distinct genetic loci and mechanisms.

Heterogeneity of Candida bloodstream isolates in an academic medical center and affiliated hospitals

This study analyzes Candida bloodstream isolates from multiple hospitals, identifying species distribution, antifungal resistance patterns, and within-patient variability in drug susceptibility.

The Maximum-Tolerated Dose and Pharmacokinetics of ISFP10 a Novel Inhibitor of Fungal Phosphoglucomutase (PGM)

This paper determines the maximum-tolerated dose and pharmacokinetics of ISFP10, a fungal PGM inhibitor, in mice, showing no safety concerns up to 100 mg/kg.

Altered susceptibility of rare yeast species causing vulvovaginal candidiasis at acidic vaginal environment

This study assesses antifungal susceptibility of rare yeast species causing VVC at acidic pH, finding that terconazole, amphotericin B, and nystatin show increased MICs at pH 4.5 compared to pH 7.0, while 5-flucytosine remains unaffected.

Transcriptional analysis of developing Aspergillus fumigatus biofilms reveals metabolic shifts required for biofilm maintenance

This study uses transcriptomics to identify metabolic shifts and genes important for maintaining mature A. fumigatus biofilms.

Aspergillus latus: a cryptic causative agent of aspergillosis emerging in Japan

This study identifies Aspergillus latus, a hybrid species, as a causative agent of aspergillosis in Japan, showing reduced susceptibility to certain antifungals.

Identification and evaluation of besifloxacin as repurposed antifungal drug in combination with fluconazole against Candida albicans

This study identifies besifloxacin as a repurposed antifungal drug that synergizes with fluconazole to inhibit Candida albicans growth and reduce fungal load in mice.

A Candidozyma (Candida) auris-optimized Episomal Plasmid Induced Cas9-editing system reveals the direct impact of the S639F encoding FKS1 mutation

The paper develops an EPIC gene-editing system for Candida auris to study the impact of FKS1 S639F mutation on echinocandin resistance, showing increased resistance and altered cell wall composition.

Varied mutual growth inhibition between commensal yeasts and strains

This study investigates the varied mutual growth inhibition between commensal yeasts and Escherichia coli strains, identifying species-specific inhibitory effects and potential antimicrobial compounds.

Widely dispersed clonal expansion of multi-fungicide-resistant Aspergillus fumigatus limits genomic epidemiology prospects

This study links triazole-resistant A. fumigatus isolates from environmental hotspots to clinical cases of aspergillosis, showing widespread clonal expansion that limits genomic epidemiology's ability to trace infection sources.

Broad-Spectrum Activity and Mechanisms of Action of SQ109 on a Variety of Fungi

This study evaluates SQ109's antifungal activity against sixteen fungal pathogens and identifies its mechanisms involving mitochondrial targeting and isoprenoid biosynthesis pathway inhibition.

Membrane damage during Candida albicans epithelial invasion is localized to distinct host subcellular niches

This study identifies two distinct host subcellular niches where membrane damage occurs during Candida albicans invasion, with the cell-cell boundary being the main driver of host cell death.

FIRST REPORT OF CANDIDA AURIS IN VIETNAM.

This paper reports the first antifungal susceptibility testing of Candida auris in Vietnam using the Sensititre YeastOne system, showing resistance patterns to three antifungal classes.

Mutations in transcription factors that confer fluconazole resistance also confer reduced susceptibility to manogepix in Candida auris, Candida albicans, Candida parapsilosis, and Candida glabrata (Nakaseomyces glabratus)

The paper identifies mutations in transcription factors that confer fluconazole resistance and also reduce susceptibility to manogepix in multiple Candida species.

Essential role of Hepcidin in host resistance to disseminated candidiasis

This study shows hepcidin deficiency increases susceptibility to Candida albicans infection by promoting fungal growth and kidney damage, and suggests hepcidin mimetics as a potential treatment.

A conserved in vivo burn wound infection model for diverse pathogenic fungi.

This paper establishes a zebrafish burn wound model to study fungal colonization and host immune responses, finding that macrophages and neutrophils control fungal infection with some redundancy.

Immunotherapy with nebulized pattern recognition receptor agonists restores severe immune paralysis and improves outcomes in mice with influenza-associated pulmonary aspergillosis

This study shows that nebulized Toll-like receptor agonists improve survival and immune function in a mouse model of influenza-associated pulmonary aspergillosis.

Characterization of a Novel FKS1 Mutation in Candida lusitaniae Shows a Potential Critical Role for MKC1 in Echinocandin Resistance

This study identifies a novel FKS1 mutation in Candida lusitaniae that confers echinocandin resistance through activation of the CWI pathway via MKC1.

Forward genetic screen in zebrafish identifies new fungal regulators that limit host-protective Candida-innate immune interaction

The paper identifies new fungal regulators in zebrafish that modulate Candida-phagocyte interactions, with NMD5 playing a key role in limiting phagocytosis and virulence.

Relative contributions of the ERG11VF125AL and MRR1AN647T mutations to fluconazole resistance in Clade III Candidozyma (Candida) auris clinical isolates

This study shows that the ERG11 mutation, not MRR1A, is primarily responsible for fluconazole resistance in Clade III C. auris isolates, while both mutations modestly affect voriconazole resistance but not other azoles.

Expression of human CEACAMs promotes inflammation and organ damage during systemic Candida albicans infection in mice

This study shows that human CEACAM receptors in mice worsen inflammation and organ damage during Candida albicans infection, leading to shorter survival.

Fighting Aspergillus infection using biocontrol bacteria: A proof-of-concept of environmental interference in a translational setting

The paper demonstrates biocontrol using oxalotrophic bacteria to combat Aspergillus niger in a mouse infection model by interfering with oxalic acid production.

Mitochondrial defects result in decreased susceptibility to echinocandins via the transcriptional regulator Pdr1 in Candida glabrata.

This study shows that mitochondrial defects increase resistance to echinocandins in Candida glabrata via Pdr1-mediated upregulation of PDR1 expression.

Adiponectin pathway activation dampens inflammation and enhances alveolar macrophage fungal killing via LC3-associated phagocytosis

This study shows that adiponectin pathway activation reduces inflammation and improves fungal killing by alveolar macrophages through LC3-associated phagocytosis in a mouse model of invasive aspergillosis.

Rapid Detection of Candida auris Using a Loop-Mediated Isothermal Amplification (LAMP) method

This study develops a LAMP method for rapid and accurate detection of Candida auris, showing it has 10 times higher sensitivity than PCR with 100% specificity.