Mesenchymal stem cell research

Functional differentiation of Human Dental Pulp Stem Cells into neuron-like cells exhibiting electrophysiological activity

This study shows that human dental pulp stem cells can be differentiated into neuron-like cells with electrophysiological activity, highlighting the importance of serum-free culture protocols.

Hypoxia-Mediated Molecular Interactions of Tissue-Specific Mesenchymal Stem Cells Drive Metabolic Reprogramming and Immunomodulation in Acute Graft-versus-Host Disease

This study compares the immunomodulatory effects of hypoxia-preconditioned bone marrow and Wharton's jelly mesenchymal stem cells in acute graft-versus-host disease, finding WJ-MSCsHYP more effective due to enhanced mitochondrial transfer and metabolic reprogramming.

Human mitochondrial transfer modeling reveals biased delivery from mesenchymal-to-hematopoietic stem cells

The paper develops iMSOD-mito, a tool to model human mesenchymal-to-hematopoietic mitochondrial transfer, showing preferential transfer to hematopoietic stem cells and functional impacts.

Immortalized Intestinal Telocytes - A Stem Cell Niche In Vitro

This paper establishes an immortalized intestinal telocyte cell line that supports stem cell organoid growth in co-culture, demonstrating telocytes' sufficiency in maintaining stem cell activity.

Synergistic Hypoxia and Apoptosis Conditioning Unleashes Superior Mesenchymal Stem Cells Efficacy in Acute Graft-versus-Host-Disease

This study shows that hypoxia and apoptosis conditioning of WJ-MSCs enhances their immune regulatory capacity in aGVHD by promoting Treg differentiation and M2 macrophage polarization.

Readaptation of mesenchymal stem cells to high stiffness and oxygen environments modulate the extracellular matrix

This study shows that culturing mesenchymal stem cells under physiological stiffness and oxygen conditions increases secretion of redox and immunomodulatory proteins while reducing extracellular matrix proteins.

Landscape of Differentiation Potentials as a "Hallmark" in Oral-derived MSCs

The paper characterizes oral-derived mesenchymal stem cells (MSCs) by analyzing their differentiation potential and identifying differentially expressed genes across three MSC subtypes.

Fructose vs. Glucose: Modulating Stem Cell Growth and Function Through Sugar Supplementation

This study investigates how glucose and fructose, along with oxygen levels, affect stem cell growth, cytokine production, and differentiation in multicellular organisms.

Mimicking physiological stiffness or oxygen levels in vitro reorganizes mesenchymal stem cells machinery toward a more naive phenotype

This paper shows that culturing MSCs on soft substrates or under low oxygen levels alters their proteome, promoting a more naive phenotype by affecting redox homeostasis, protein chaperones, and translational complexity.

Mechanical Rejuvenation of Mesenchymal Stem Cells from Aged Patients

This study shows that mechanical conditioning improves the regenerative potential of aged mesenchymal stem cells by reducing senescence and altering their genetic landscape.

Age-Related KLHL22 Expression in Human MSCs and Regenerative Implications

This study identifies KLHL22 as a gene with age-related expression in hMSCs, suggesting its potential as a marker for selecting more effective cells for regenerative therapies.

FOSL2 Gene Expression Declines with Age in Bone Marrow-derived MSCs

This study shows FOSL2 gene expression decreases with age in human bone marrow-derived mesenchymal stromal cells, suggesting its role in aging and regenerative capacity decline.

LncRNA-CIR6 Mediates Repair of Infarcted Hearts by Inducing MSCs Differentiation into Cardiogenic Cells through CDK1

This study shows LncRNA-CIR6 promotes MSC differentiation into cardiogenic cells via CDK1, improving heart repair after myocardial infarction.

Self-renewing Sox9+ osteochondral stem cells in the postnatal skeleton

The paper identifies self-renewing osteochondral stem cells in the postnatal skeleton and compares their transcriptomes across adult, fetal, mouse, and human samples.

Short heat shock has a long-term effect on mesenchymal stem cells' transcriptome

The paper shows that short heat shock alters mesenchymal stem cells' transcriptome, leading to long-term activation of lineage commitment genes.

Identification of the Metaphyseal Skeletal Stem Cell

This paper identifies a novel metaphyseal skeletal stem cell (mpSSC) population derived from hypertrophic chondrocytes that supports trabecular bone formation.

Culture of human nasal olfactory stem cells and their extracellular vesicles as advanced therapy medicinal products

The paper develops a clinical-grade manufacturing protocol for olfactory stem cells and their extracellular vesicles, validated using nasal mucosa biopsies and demonstrating neurogenic properties in vitro.

Canonical Wnt Signaling Maintains Human Mesenchymal Progenitor Cell Multipotency During Adipose Tissue Development

IFT20 governs mesenchymal stem cell fate through positively regulating TGF-β-Smad2/3-Glut1 signaling mediated glucose metabolism

This study shows IFT20 regulates mesenchymal stem cell fate by controlling TGF-β-Smad2/3-Glut1 signaling and glucose metabolism, preventing adipocyte differentiation.

Invigorating human MSCs for transplantation therapy via Nrf2/DKK1 co- stimulation in a mice acute-on-chronic liver failure model

This study shows that co-stimulating Nrf2 and DKK1 in human MSCs improves their therapeutic efficacy in a mouse ACLF model by enhancing anti-inflammatory and regenerative effects.

The Role of Human Platelet-Rich Plasma to Enhance the Differentiation from Adipose derived Mesenchymal Stem Cells into Cardiomyocyte: An Experimental Study

This study examines the effect of platelet-rich plasma on adipose-derived mesenchymal stem cells differentiation into cardiomyocytes, finding significant improvements in GATA-4 and cTnT expression compared to controls.

Mesenchymal stem cell subpopulations and their heterogeneity of response to inductions revealed by single-cell RNA-seq

The paper identifies MSC subpopulations and their differential responses to inductions using single-cell RNA-seq, revealing subtype-specific gene expression and differentiation potential.

Mapping SOX9 transcriptional dynamics during multi-lineage differentiation of human mesenchymal stem cells

The paper investigates SOX9 transcriptional dynamics in human mesenchymal stem cells during differentiation into chondrogenic, osteogenic, and adipogenic lineages, revealing subpopulations and donor-specific differences.

Human primed endothelial colony forming cells exert neuroprotective effects in the growth restricted newborn piglet

This study shows that primed endothelial colony forming cells improve brain outcomes in growth restricted newborn piglets by repairing vasculature and reducing inflammation.

The small and large intestine contain transcriptionally related mesenchymal stromal cell subsets that derive from embryonic Gli1+ mesothelial cells

Differentiation of human adult-derived stem cells towards a neural lineage involves a de-differentiation event prior to re-differentiation to neural phenotypes

This study shows that human adult stem cells differentiate into neural cells through a de-differentiation step followed by re-differentiation, confirmed by observing morphology changes and micronuclei movement.

Comparative Transcriptomics Identifies Potential Stemness-Related Markers for Mesenchymal Stromal/Stem Cells

This study identifies six proteasome degradation system genes as potential stemness markers for MSCs across multiple tissue sources using comparative transcriptomics and predictive models.

Induced neural differentiation of human mesenchymal stem cells affects lipid metabolism pathways

This study shows that inducing neural differentiation in human mesenchymal stem cells alters lipid metabolism pathways, specifically affecting arachidonic acid and docosahexaenoic acid metabolism.

Augmentation of Antibacterial Activity in Mesenchymal Stromal Cells Through Systems-Level Analysis and CRISPR-mediated Activation of CD14

This study identifies CD14 as a key target to enhance antibacterial activity in mesenchymal stromal cells through systems-level analysis and CRISPR activation.

Neurons from human mesenchymal stem cells display both spontaneous and stimuli responsive activity

This study shows that human mesenchymal stem cells can differentiate into functional neurons with spontaneous activity and respond to electrical stimuli.