Hearing, Cochlea, Tinnitus, Genetics

Tonic sound-evoked motility of cochlear outer hair cells in mice with impaired mechanotransduction

The paper investigates tonic sound-evoked motility in mice with impaired mechanotransduction, finding that tonic responses occur even without functional amplification.

Changes in urinary proteome of rats before and after noise exposure

This study identifies 219 differentially expressed urinary proteins in rats after high-decibel noise exposure, 30 of which are linked to hearing loss.

Low-side and multitone suppression in the base of the gerbil cochlea

The paper investigates suppression in the gerbil cochlea using optical coherence tomography, finding frequency-specific suppression patterns and suggesting nonlinear mechanisms involving motion amplitude and vibration axis changes.

Sex-specific age-related changes in excitatory and inhibitory intra-cortical circuits in mouse primary auditory cortex

This study examines age-related changes in excitatory and inhibitory circuits in the auditory cortex of male and female mice, finding sex-specific reductions in connectivity.

Heterogeneous group of genetically determined auditory neuropathy spectrum disorders

The paper identifies genetic variants in ANSD patients and shows differences in auditory tests between ANSD and SNHL groups, suggesting ASSR testing for better diagnosis.

Rapid and objective assessment of auditory temporal processing using dynamic amplitude-modulated stimuli

This paper introduces a faster and more efficient method to measure envelope following responses (EFRs) using dynamic amplitude-modulated stimuli, achieving higher spectrotemporal resolution and reduced recording time across multiple species.

Multiple mechanisms of aminoglycoside ototoxicity are distinguished by subcellular localization of action

The paper distinguishes two mechanisms of aminoglycoside ototoxicity in zebrafish hair cells based on subcellular localization and timing of cellular responses.

Sex differences in auditory function of the desert locust

The paper investigates sex differences in auditory decline in Desert Locusts, finding that females show less decline and identify gene expression differences linked to hormones and metabolism.

Does age protect against loss of tonotopy after acute deafness in adulthood?

This study investigates how age affects the preservation of tonotopy after acute deafness in adult rats, finding that older rats maintain tonotopy better than younger rats.

Comprehensive genetic analysis of STRC variants in hereditary hearing impairment using long-read sequencing

This study uses long-read sequencing to identify STRC variants in patients with hereditary hearing impairment, finding 11% diagnostic yield and highlighting LRS's ability to detect complex variants missed by conventional NGS.

PKHD1L1 is required for stereocilia bundle maintenance, durable hearing function and resilience to noise exposure.

This study shows PKHD1L1 is essential for maintaining stereocilia bundles, hearing function, and resilience to noise in mice, with loss leading to age-related hearing loss and susceptibility to noise damage.

Tanshinone IIA potentiates the therapeutic efficacy of glucocorticoid in lipopolysaccharide-treated HEI-OC1 cells through modulation of Foxp3/Nrf2 signaling pathway

This study shows that tanshinone IIA enhances glucocorticoid efficacy in LPS-treated HEI-OC1 cells by modulating the Foxp3/Nrf2 signaling pathway.

Single-cell, spatial, and fate-mapping analyses uncover niche dependent diversity of cochlear myeloid cells.

This study identifies five myeloid cell types in the mouse cochlea using single-cell transcriptomics, fate mapping, and parabiosis, revealing their spatial distribution, ontogeny, and functional diversity.

Local Delivery of Soluble Fractalkine (CX3CL1) Peptide Restore Ribbon Synapses After Noise-Induced Cochlear Synaptopathy

This study shows that local delivery of soluble FKN peptide restores lost inner hair cell ribbon synapses and hearing after noise-induced cochlear synaptopathy in a macrophage-dependent manner.

Spatiotemporal transcriptomic analyses reveal molecular gradient patterning during development and the tonotopic organization along cochlear axis

The paper constructs a single-cell-resolution spatial transcriptomic atlas of mouse cochlear development, revealing molecular gradients and tonotopic organization along the cochlear axis.

PAM-flexible adenine base editing rescues hearing loss in a humanized MPZL2 mouse model harboring an East Asian founder mutation

This study uses base editing to correct a mutation causing hearing loss in a humanized mouse model, restoring hearing function and gene expression.

Irx3/5 define the cochlear sensory domain and regulate vestibular and cochlear sensory patterning in the mammalian inner ear

This study shows that Irx3/5 genes are critical for patterning vestibular and cochlear sensory domains in the mammalian inner ear, with their deletion causing structural and cellular abnormalities in the cochlea.

Molecular Specializations Underlying Phenotypic Differences in Inner Ear Hair Cells of Zebrafish and Mice

This study compares gene expression in zebrafish and mouse inner ear hair cells to identify molecular differences underlying their physiological specializations.

ATP-gated P2x7 receptor is a major channel type at type II auditory nerves and required for hearing sensitivity efferent controlling and noise protection

This study identifies the ATP-gated P2x7 receptor as a key channel in type II auditory nerves, showing its role in hearing sensitivity and noise protection through efferent control mechanisms.

KLHDC7B, a novel gene associated with age-related hearing loss in humans, is required for the maintenance of hearing in mice.

This paper identifies KLHDC7B as a gene associated with age-related hearing loss in humans and validates its role in hearing maintenance using two mouse models.

Cellular Reprogramming by Notch Inhibition Regenerates Hair Cells and Afferent Neurons to Restore the Sense of Balance

A gamma-secretase inhibitor regenerates hair cells and afferent neurons in a mouse model, restoring balance function.

Ototoxicity-related Changes in GABA Immunolabeling Within the Rat Inferior Colliculus

The paper examines changes in GABA immunolabeling in the rat inferior colliculus following ototoxic hearing loss, finding reduced intensity and density of GABAergic inputs.

Long-Read Sequencing Increases Diagnostic Yield for Pediatric Sensorineural Hearing Loss

This study evaluates the diagnostic yield of long-read sequencing in pediatric sensorineural hearing loss, finding it detects structural variants missed by short-read sequencing.

Modulating the Unfolded Protein Response with ISRIB Mitigates Cisplatin Ototoxicity

This study shows that ISRIB reduces cisplatin-induced hearing loss and hair-cell death without affecting its cytotoxicity in cancer cells.

Dynamic modulation of auditory hair cell stereocilia membrane mechanics by the scrambling mechanotransduction complex

The paper investigates the scramblase activity of TMC1 and TMC2 in auditory hair cells, showing their role in modulating stereocilia membrane mechanics during mechanotransduction.

Evaluating the Effects of Aircraft Noise on Hearing and Physiological Indicators: A Study of Military Personnel Using iTRAQ Proteomics and Cognitive Assessments

This study evaluates aircraft noise effects on hearing and physiological indicators in military personnel using proteomics and cognitive assessments, finding hearing impairment and links to oxidative stress and inflammation.

Rfx3 controls outer hair cell differentiation, maintenance, and hair bundle formation by regulating the expression of Insm1, Ikzf2, and Triobp genes

This study identifies Rfx3's role in outer hair cell development by regulating Insm1, Ikzf2, and Triobp through transcriptional activation and repression.

Compartment coupling integrates patterning and morphogenetic information during development

The paper investigates how compartment coupling coordinates patterning and morphogenetic information in the mouse organ of Corti, revealing vinculin-dependent junctional mechanics as a key mechanism.

foxg1a is required for hair cell development and regeneration in the zebrafish lateral line

This study shows that Foxg1a is essential for hair cell development and regeneration in zebrafish lateral line system by promoting cellular proliferation.

Rapid Emergence of an Adaptive Spatial Representation

The paper shows that neural representations of auditory space rapidly reorganize after binaural cue disruption without overwriting existing codes.