Hematopoietic Stem Cell Transplantation

This study maps human hematopoiesis at single-cell resolution, revealing aging-associated topographic remodeling in bone marrow.

The paper identifies NOTCH1-JAG1 cis interactions regulated by RADICAL FRINGE that maintain hematopoietic stem cell fate during development.

The paper identifies CD32 as a marker for hemogenic endothelial cells in human embryos and shows its role in hematopoietic commitment.

This study identifies a nitric oxide-dependent metabolic pathway in stress erythroid progenitors that promotes proliferation and inhibits differentiation during inflammatory anemia.

This study identifies Rasip1 as a downstream target of Sox17 that enhances hematopoietic activity in intra-aortic hematopoietic clusters of midgestation mouse embryos.

The paper identifies IGFBP2 as a key factor secreted by arterial cells that enhances hematopoietic progenitor development in vitro.

This study shows that miR-128 regulates HSPC heterogeneity by modulating Wnt and Notch signaling in hemogenic endothelium, leading to lineage-specific biases in zebrafish and human systems.

This study investigates the association between predicted minor histocompatibility antigens (mHAs) and clinical outcomes in allogeneic hematopoietic cell transplantation using multivariate survival models.

The paper maps the multi-organ functions of the human yolk sac during early development, revealing its roles in hematopoiesis, nutrition, and oxygen regulation.

This study uses in vivo CRISPR screening to identify SAGA complex members as key regulators of hematopoiesis, showing their loss impairs blood production and activates interferon pathways.

The paper shows that fetal lung contains hemogenic endothelial cells capable of undergoing endothelial to hematopoietic transition to generate de-novo hematopoietic stem and progenitor cells.

The paper identifies a Lin28b-let-7-PRC1 axis that regulates hematopoietic maturation across development, with Cbx2 playing a key role in controlling developmental timing of hematopoietic transcription factors.

The paper shows that HSC-independent hematopoietic progenitors persist into adulthood, challenging the HSC-centric model of blood cell development.

The paper links DNA methylation changes in HSCs from large for gestational age neonates to altered quiescence via transcriptional network disruption.

The paper investigates the role of Tal1, Lmo2, and Lyl1 in the Endothelial to Hematopoietic Transition using a mouse embryonic-stem cell model and multi-omics approaches, finding that Tal1 expression in endothelial cells is crucial for the transition.

This study shows that endothelial-specific Gata3 expression is required for the maturation of haemogenic endothelial cells into haematopoietic stem cells during the endothelial-to-haematopoietic transition.

The paper shows p57Kip2 limits HSC numbers by restricting SNS progenitor size and catecholamine secretion in the AGM region via β2-adrenergic signaling.

The paper uses single cell RNA-seq to study human hematopoietic stem and progenitor cells (HSPCs) across development and aging, revealing age-related transcriptional changes and differentiation trajectories.

This study shows that DDX41 is essential for hematopoietic stem cell differentiation in mice, particularly affecting myeloid progenitor development and gene expression programs.

The paper identifies a unique myeloid progenitor cell type, TC90, specific to neonatal naked mole-rats that supports innate immunity during early development.

This study identifies site- and stage-specific transitions in gene regulatory networks and lineage specification in human hematopoietic stem and progenitor cells across developmental stages.

This study shows that PADI4 is not required for HSC maintenance, differentiation, or haematopoietic regeneration in mice.

The paper identifies a triad of myeloid cells and endothelial cells that collaborate to produce PGE2 and expand hematopoietic stem cells in the fetal niche.

The paper was withdrawn due to lack of author consent and is not intended for citation.

The paper shows that GATA2 deficiency during embryogenesis leads to elevated IRF8, which disrupts progenitor cell differentiation by altering the balance of myelo-erythroid progeny.

The paper identifies key signaling molecules involved in HSC development by analyzing single-cell transcriptomics data from AGM-derived cells and uses them to engineer a supportive niche for HSC generation.

This study investigates the role of DOT1L in hematopoietic progenitor cells by analyzing transcriptomes of knockout and mutant models, revealing its function as a transcriptional repressor.

This study shows that DOT1L methyltransferase activity is essential for early murine hematopoiesis, as its loss causes embryonic lethality and genomic instability in hematopoietic progenitors.

The paper identifies Notch glycosylation and Mycn upregulation as critical for endothelial-to-hematopoietic transition during HSC development.

The paper investigates HSC division patterns in mice, finding most divisions are symmetric self-renewing, maintaining HSC output despite age-related decline in differentiation.