Ion channel regulation and function

Cholinergic modulation of membrane properties of calyx terminals in the vestibular periphery

This study investigates how cholinergic inputs modulate membrane properties and firing patterns of calyx terminals in the vestibular system through KCNQ channel activity.

Structure Basis of Cav1.1 Modulation by Dihydropyridine Compounds

This study reports cryo-EM structures of Cav1.1 bound to DHP compounds, revealing the molecular basis for chiral specificity and drug efficacy.

Optical measurement of physiological sodium currents in the axon initial segment

The paper improves Na+ imaging temporal resolution to directly measure Na+ currents in the axon initial segment of mouse pyramidal neurons, identifying subthreshold, fast inactivating, and persistent currents.

Novel target identification using single cell sequencing and electrophysiology of cardiac sympathetic neurons in disease

The paper identifies mechanisms of hyperactivity in cardiac sympathetic neurons using single-cell RNA-sequencing and electrophysiology, showing potential therapeutic targets to reduce sympathetic activity.

VOLTAGE-GATED POTASSIUM CHANNELS CONTROL THE GAIN OF ROD-DRIVEN LIGHT RESPONSES IN MIXED-INPUT ON BIPOLAR CELLS

This paper shows voltage-gated potassium channels in mixed-input ON bipolar cells adjust rod signal gain and create transient responses, enhancing dynamic range and reducing temporal redundancy.

Species differences in the cerebellar distribution of six members of the Kv1 channel subfamily.

The paper compares the cerebellar distribution of Kv1 channel subfamily members across species, finding marked differences in Kv1.4 and Kv1.6 between primates and rodents.

Alternative splicing tunes sodium channels to support channel- and neuron- specific effects

The paper shows that alternative splicing of sodium channels Nav1.1 and Nav1.2 has cell-type-specific effects on neuronal activity and firing properties.

Effect of FMRFamide on voltage-dependent currents in identified centrifugal neurons of the optic lobe of the cuttlefish, Sepia officinalis

This study characterizes voltage-dependent currents in cuttlefish centrifugal neurons and shows that FMRFamide reduces multiple currents, suggesting an inhibitory role in visual processing.

Impaired M-current in KCNQ2 Encephalopathy Evokes Dyshomeostatic Modulation of Excitability

This study investigates how KCNQ2 mutations affect neuronal excitability in patient-derived neurons, finding progressive hyperexcitability and altered firing patterns linked to impaired M-current.

Electrical match between initial segment and somatodendritic compartment for action potential backpropagation in retinal ganglion cells

The paper measures axial current in mouse retinal ganglion cells to show how the axon initial segment supports reliable action potential backpropagation through high sodium conductance and charge preservation.

The KCNQ4-mediated M-current regulates the circadian rhythm in mesopontine cholinergic neurons

The paper investigates the role of KCNQ4-mediated M-current in regulating circadian rhythms in mesopontine cholinergic neurons and identifies its impact on neuronal synchronization and sleep-wakefulness cycles.

Discovery of a Selective, State-Independent Inhibitor of NaV1.7 by Modification of Guanidinium Toxins

This paper describes the discovery of ST-2262, a selective NaV1.7 inhibitor with state-independent action, showing reduced pain sensitivity in non-human primates.

Different α2δ Accessory Subunits Regulate Distinctly Different Aspects of Calcium Channel Function in the Same Drosophila Neurons

This study shows that different 2{delta} subunits in Drosophila neurons regulate distinct aspects of calcium channel function, such as current amplitude and subcellular localization.

Functional and Pharmacological Evaluation of a Novel SCN2A Variant Linked to Early-onset Epilepsy

The paper evaluates a novel SCN2A variant linked to early-onset epilepsy, showing it causes gain-of-function effects and responds to carbamazepine.

Nav1.7 gating in human iPSC derived sensory neurons: an experimental and computational study

The paper combines experimental and computational approaches to study Nav1.7 channel behavior in human iPSC-derived sensory neurons, showing how mutations and toxins affect neuronal excitability and pain mechanisms.

Cryo-EM structures of calcium homeostasis modulator channels in diverse oligomeric assemblies

The paper presents cryo-EM structures of CALHM channels from different species, revealing their ATP conduction and oligomerization mechanisms.

Uncoupling sodium channel dimers rescues phenotype of pain-linked Nav1.7 mutation

The paper shows that uncoupling dimerized Nav1.7 channels reduces persistent current caused by a pain mutation, suggesting dimerization plays a role in pain syndromes.

A calcineurin-mediated scaling mechanism that controls a K+-leak channel to regulate morphogen and growth factor transcription

The paper shows how calcineurin regulates Kcnk5b to control gene expression and allometric growth in zebrafish appendages.

Calcium-induced calcium release and type 3 ryanodine receptors modulate the slow afterhyperpolarising current, sIAHP, and its potentiation in hippocampal pyramidal neurons

This study investigates how calcium-induced calcium release via RyR3 receptors modulates the sIAHP current and its activity-dependent potentiation in hippocampal pyramidal neurons.

Two opposite voltage-dependent currents control the unusual early development pattern of embryonic Renshaw cell electrical activity

The paper identifies two voltage-dependent currents that regulate the functional diversity and developmental trajectory of embryonic Renshaw cells.

Spike-frequency adaptation is modulated by interacting currents in an Hodgkin-Huxley-type model: Role of the Na,K-ATPase

The paper studies spike-frequency adaptation in a Hodgkin-Huxley-type model, showing how Na,K-ATPase and calcium-dependent potassium channels interact to shape neuronal firing patterns.

Coupling of Ca2+ and voltage activation in BK channels through the αB helix/voltage sensor interface

This study investigates how the B helix/voltage sensor interface in BK channels couples Ca2+ and voltage activation, showing its role in transducing both signals to pore opening.

Preferential Pharmacological Inhibition of Nav1.6, but not Nav1.1, Abolishes Epileptiform Activity Induced by 4-AP in Mouse Cortical Slices

This study investigates the effects of inhibiting specific voltage-gated sodium channel isoforms on epileptiform activity in mouse cortical slices, finding that Nav1.6 inhibition is more effective than Nav1.1 inhibition.

CRISPR Knockdown of Kcnq3 Attenuates the M-current in NPY/AgRP Neurons

This study uses CRISPR to knock down Kcnq3 in NPY/AgRP neurons, reducing the M-current and increasing neuronal excitability without affecting ingestive behavior but decreasing locomotor activity.

Kv1 potassium channels control action potential firing of putative GABAergic deep cerebellar nuclear neurons.

The paper investigates the role of Kv1 potassium channels in regulating the activity of GABAergic deep cerebellar nuclear neurons using pharmacological blockers in mouse models.

Rapid adaptation to elevated extracellular potassium in the pyloric circuit of the crab, Cancer borealis

The paper investigates how elevated extracellular potassium affects neuronal activity in the crab pyloric circuit, revealing transient loss followed by recovery of spiking and bursting activity.

Slo2 potassium channel function depends on a SCYL1 protein

The paper shows SCYL1 regulates Slo2 potassium channels in C. elegans and humans, with SCYL1 enhancing channel activity in human cells and reducing it in worms.

A regulatory domain in the K2P2.1 (TREK-1) carboxyl-terminal allows for channel activation by monoterpenes

This study identifies a regulatory domain in the K2P2.1 channel that enables activation by monoterpenes, with a specific triple arginine motif essential for this effect.

Theoretical relation between axon initial segment geometry and excitability

The paper derives a theoretical formula linking axon initial segment geometry and sodium conductance density to somatic voltage threshold, showing how AIS position affects excitability.

Pro-inflammatory cytokines drive deregulation of potassium channel expression in primary synovial fibroblasts

The paper investigates how TNF and IL1β cytokines affect potassium channel expression in rat synovial fibroblasts, finding increased Kcnma1 and Kcnmb3 gene expression.