Toxoplasma gondii Research Studies

In vivo CRISPR screens identify GRA12 as a transcendent secreted virulence factor across Toxoplasma gondii strains and mouse subspecies

The paper identifies GRA12 as a critical secreted virulence factor in Toxoplasma gondii that functions across different parasite strains and mouse species.

Metabolic Adaptability and Nutrient Scavenging in Toxoplasma gondii: Insights from Ingestion Pathway-Deficient Mutants

This study investigates the role of the ingestion pathway in Toxoplasma gondii nutrient acquisition by analyzing mutants lacking key pathway components, revealing reliance on biosynthetic pathways and highlighting the pathway's role in nutrient scarcity.

The essential kinase TgGSK regulates centrosome division and endodyogeny in Toxoplasma gondii

This study identifies TgGSK as an essential kinase in Toxoplasma gondii that regulates centrosome division and endodyogeny, with roles in RNA processing and interactions with GCN5b.

Unveiling the Unique Structure and Singular Function of the Histone Deacetylase 2 (TgHDAC2) of Toxoplasma gondii

This study identifies TgHDAC2 in Toxoplasma gondii as a class I HDAC that deacetylates non-histone proteins, essential for cell cycle regulation and replication.

Toxoplasma gondii infection accelerates the progression of hereditary spastic paraplegia

This study investigates how chronic Toxoplasma gondii infection affects neurodegenerative disease progression in a rat model of hereditary spastic paraplegia, finding exacerbated symptoms in infected rats.

Toxoplasma induced cytokine release syndrome is critically dependent on the expression of pore-forming Perforin-Like Protein-1

This study shows that Toxoplasma gondii's PLP1 protein drives cytokine release syndrome by inducing dysregulated immune responses, leading to lethal inflammation during acute infection.

Toxoplasma gondii PROP1 is critical for autophagy and parasite viability during chronic infection

This study identifies TgPROP1 as essential for autophagy and chronic infection of Toxoplasma gondii bradyzoites, while TgPROP2 is not involved in bradyzoite autophagy.

Toxoplasma in a natural population of chimpanzees

This study examines Toxoplasma gondii prevalence in wild chimpanzees, finding higher infection rates in a community with greater human interaction and among high-ranking males.

Activity of Carbazole, Aminoguanidine and Diamine Anti-infectives against Toxoplasma gondii

The paper tests carbazole, aminoguanidine, and diamine anti-infectives against Toxoplasma gondii, finding low IC50 values and protonophore uncoupling activity.

Anti-Toxoplasma gondii screening of eight species and bio-guided identification of metabolites of Elaeis guineensis leaves, a preliminary study

This study evaluates the anti-Toxoplasma gondii activity of extracts from eight plants, identifies nine compounds from Elaeis guineensis leaves, and suggests a synergistic effect among them.

Motility-dependent processes in Toxoplasma gondii tachyzoites and bradyzoites: same same but different

This study compares motility and motility-dependent processes in Toxoplasma gondii tachyzoites and bradyzoites, revealing similarities and differences in their movement and invasion capabilities.

High Throughput Repurposing Screen Reveals Compounds with Activity Against Toxoplasma gondii Bradyzoites

The paper identifies 44 compounds with >50% inhibitory effects against Toxoplasma gondii bradyzoites using a high-throughput screen and characterizes one compound's activity.

Toxoplasma strikes preemptively to swiftly suppress macrophage immune response during active infection

This study uses time-resolved transcriptomic profiling to analyze host and parasite gene expression during early Toxoplasma gondii infection in mouse macrophages, revealing rapid host immune responses and delayed parasite transcriptional activation.

TgGloL is an atypical glyoxalase/VOC domain-containing apicoplast protein that is important for the growth of Toxoplasma

The paper identifies TgGloL, an atypical apicoplast protein in Toxoplasma gondii, essential for parasite growth and organelle homeostasis.

Long Noncoding RNA Mir17hg and D43Rik Control the Macrophage Response to Toxoplasma gondii Infection

This study shows that lncRNAs Mir17hg and D43Rik regulate the macrophage response to Toxoplasma gondii infection by modulating the host transcriptional response.

Toxoplasma gondii from Gabonese forest, Central Africa: first report of an African wild population

This study identifies a novel genotype of Toxoplasma gondii from wild animals in Gabon, Africa, which is genetically distinct from domestic and other global populations.

Extracts of food and medicinal plants sold in Moroccan markets induce apoptosis-like in Toxoplasma gondii tachyzoites in vitro

The paper tests extracts from Moroccan plants for anti-Toxoplasma effects and finds some induce apoptosis-like changes in tachyzoites with low cytotoxicity.

Paracrine rescue of MYR1-deficient Toxoplasma gondii mutants reveals limitations of pooled in vivo CRISPR screens

The paper shows that MYR1-deficient Toxoplasma gondii mutants are rescued by co-infection with wild-type parasites in mice, revealing a limitation of pooled in vivo CRISPR screens.

CD4 Co-Receptor Regulates Sex-Specific NK Cell Responses to Acute Toxoplasma gondii Infection.

This study shows that CD4 co-receptor deficiency leads to faster death in female mice infected with T. gondii due to reduced IFN-gamma+ NK cells, but not in males.

Immunization with Plant-based Vaccine Expressing Toxoplasma gondii SAG1 Fused to Plant HSP90 Elicits Protective Immune Response in Lambs

This study evaluates two vaccines against Toxoplasma gondii in lambs, showing that the recombinant vaccine increases anti-SAG1 IgG and the plant vaccine boosts IFN-γ levels and reduces histopathological lesions.

Cap-independent translation directs stress-induced differentiation of the protozoan parasite Toxoplasma gondii

This study identifies cap-independent translation as a mechanism driving stress-induced differentiation in Toxoplasma gondii by regulating BFD1 protein synthesis.

A bioinformatic approach for the prediction andfunctional classification of Toxoplasma gondii longnon-coding RNAs

The paper predicts and functionally classifies long non-coding RNAs in Toxoplasma gondii during differentiation, identifying stage-specific expression and potential roles in DNA damage repair.

Characterization of atypical BAR domain-containing proteins coded by Toxoplasma gondii

This study characterizes two atypical BAR domain-containing proteins in Toxoplasma gondii, revealing their distinct membrane-binding properties and roles in parasite trafficking.

TgATG9 is required for autophagosome biogenesis and maintenance of chronic infection in Toxoplasma gondii

This study identifies TgATG9 as essential for autophagosome formation and chronic Toxoplasma gondii infection.

N-terminal targeting sequences and coding sequences act in concert to determine the localization and trafficking pathway of apicoplast proteins in Toxoplasma gondii.

Toxoplasma gondii transcription factor AP2XII-8: a key regulator of G1 phase progression and parasite division

This study identifies TgAP2XII-8 as a critical regulator of G1 phase progression and parasite division in Toxoplasma gondii tachyzoites through functional characterization and genomic analysis.

Characterisation of cell cycle checkpoint kinases in Toxoplasma gondii

This study identifies and characterizes the DNA damage checkpoint kinases ATM and ATR in Toxoplasma gondii, revealing their unique roles in regulating replication and response to DNA damage.

The initiation and early development of apical-basal polarity in Toxoplasma gondii

This study investigates the initiation and early development of apical-basal polarity in Toxoplasma gondii using expansion microscopy, revealing the synchronized development of apical and basal structures and the synergistic role of APR2 and KinesinA.

Cyclical transcription factor AP2XII-9 is a key activator for asexual division and apicoplast inheritance in Toxoplasma gondii tachyzoite

This study identifies TgAP2XII-9 as a critical S/M-phase transcription factor regulating endodyogeny and apicoplast inheritance in Toxoplasma gondii tachyzoites.

Expansion of in vitro Toxoplasma gondii cysts using enzymatically enhanced ultrastructure expansion microscopy

This paper introduces an enzymatic digestion step using StcE to enable ultrastructure expansion microscopy of Toxoplasma gondii cysts, allowing detailed super-resolution analysis of the chronic infection stage.