Neuroinflammation and Neurodegeneration Mechanisms

The paper analyzes single-cell gene expression and morphology in microglia to show how aging changes their spatial transcript organization and functional roles.

This study shows that quinpirole improves microglial dysfunction in LRRK2-R1441G transgenic mice by reversing motility and responsiveness issues.

This study uses human brain organoid microphysiological systems to show that AD patient monocytes cause increased inflammation and reduced Aβ clearance in organoids compared to controls.

This study tracks microglial state changes and neuronal asynchrony after irradiation in mice, showing delayed microglial responses and two phases of neuronal dysfunction.

This study shows DDT exposure increases neuroinflammation in microglia, potentially contributing to Alzheimer's disease risk through direct effects on microglial function.

The paper constructs an integrated atlas of astrocytes from human and mouse neurodegenerative disease models, identifying conserved and divergent subtypes across species.

The paper identifies Gpnmb as a marker of a phagocytic microglial state linked to neuronal loss in prion disease, showing its role in clearing apoptotic cells.

This study differentiates peripheral blood mononuclear cells from non-human primates into microglia-like cells to study the effects of chronic alcohol consumption on microglial function and transcriptional profiles.

The paper evaluates the long-term effects of miR-20a-3p treatment on brain pathology in female rats after ischemic stroke, finding reduced white matter volume and microglial activation in untreated animals.

This study identifies microglial subpopulations and shows their origin and transitions through transcriptomic and epigenomic analysis.

This study investigates how different levels of prenatal stress affect striatal microglia and behavior in adult offspring, finding that high and immune stress models exceed a threshold for persistent impacts.

This study examines the effects of a loss-of-function mutation in the rat Il34 gene on macrophage development, homeostasis, and inflammation in both the brain and periphery.

The paper shows that wild-type bone marrow-derived microglia-like cells reduce strain-dependent neuropathology in Csf1r mutant mice by preventing thalamic calcification.

This study shows that microglia are essential for excitatory synapse formation in the nucleus accumbens during early development, impacting threat avoidance behaviors in adulthood.

This study investigates how Kv1.3 and MAPK14 contribute to microglial oxidative stress and neuroinflammation after organic dust exposure, finding that inhibiting Kv1.3 reduces inflammation and oxidative stress markers.

This study uses a microfluidic coculture platform to investigate inflammatory crosstalk between microglia and astrocytes, revealing altered inflammatory mediator levels and microglial migration.

This study examines how wildfire smoke and diesel exhaust affect inflammatory responses in aging human microglia, showing distinct temporal and molecular effects on oxidative stress and cytokine profiles.

This study shows that microglial cathepsin B is essential for efficient neuronal efferocytosis during brain development, preventing apoptotic cell accumulation and ensuring proper neural circuit formation.

This study shows that peripheral inflammation reduces D1-MSN excitability in the NAc by increasing microglial engulfment of glutamatergic inputs.

This study shows that early-life immune activation in 5xFAD mice alters microglial responses and reduces Aβ pathology, with effects on cytokine levels and memory deficits.

This study identifies microglia as key contributors to senescence in Alzheimer's disease, linking cholesterol dysregulation to senescence pathologies through transcriptomic analysis of multiple datasets.

This study investigates the relationship between sulfatide deficiency, neuroinflammation, and lipid dyshomeostasis in a mouse model, showing Trem2's role in microglia-mediated neuroinflammation but not astrogliosis or myelin lipid disruption.

The paper generates morphologically distinct astrocyte subtypes from human iPSCs and links their shape, function, and reactivity.

This study shows nimodipine reduces microglial activation in vitro by altering gene expression and functional phenotypes.

This study shows TIA1 regulates divergent inflammatory responses in microglia and macrophages, reducing brain inflammation and tau pathology while increasing peripheral inflammation.

This study shows microglia regulate cerebral blood flow through CD39-mediated ATP breakdown, affecting neurovascular coupling and CBF reactivity.

This study shows that ADGRG1 in microglia helps protect against Alzheimer's disease by improving amyloid clearance and reducing pathology.

This study identifies dark microglia in postnatal mouse hippocampus, showing they perform synapse remodeling via phagocytosis and trogocytosis and depend on TREM2.

This paper shows that combined Alzheimer's and Parkinson's protein pathologies enhance neuroinflammation and neurodegeneration in a mouse model.