Neuroinflammation and Neurodegeneration Mechanisms

The paper shows that microglia phagocytosing neurons with tau aggregates become hypofunctional and release tau seeds, contributing to tauopathy progression.

This study investigates the role of P2Y12R in Parkinson's disease progression in mice, showing that its inhibition can protect against neurodegeneration and neuroinflammation.

This study shows that deleting Presenilin 1 in microglia during development enhances memory and neuronal activity in mice, with effects dependent on GluN2B and mitigating Alzheimer's symptoms.

This study shows that microglial NKCC1 regulates ion homeostasis, inflammation, and brain injury through cell-autonomous mechanisms.

This paper characterizes microglial metabolic changes in an APP knock-in mouse model of AD, finding lipid dysregulation and immunometabolic perturbations linked to fibrillar Aβ.

This study shows that loss of basal forebrain cholinergic signaling leads to microglial activation and exaggerated inflammatory responses to systemic inflammation.

The paper shows that microglia perform local protein synthesis in peripheral processes to support phagocytic activity and lysosomal machinery assembly.

This study examines how neuroinflammation affects astrocyte gene expression in the mouse medial prefrontal cortex and links these changes to anhedonia, finding shared pathways with human major depressive disorder and Alzheimer's disease.

This study shows that cortical stroke causes long-lasting gliosis in the ipsilateral thalamus, with memantine reducing gliosis at 2 weeks post-stroke.

This study shows that incorporating microglial progenitors into human brain organoids supports neuronal maturation and synaptic activity.

The paper investigates how systemic inflammation affects synaptic plasticity using repetitive magnetic stimulation and shows that anti-inflammatory cytokines can restore plasticity in inflamed tissue cultures.

This study shows that microglia promote zebrafish brain repair through specific inflammatory signaling pathways, highlighting their role in neurogenesis and inflammation resolution.

The paper identifies gene expression changes in Alzheimer's disease pathology linked to cognitive impairment in hydrocephalus biopsies, showing microglial activation and loss of homeostatic genes.

This study investigates how chronic intermittent ethanol affects microglial translatome in striatum, identifying CHOP and UPR as key factors in ethanol withdrawal symptoms.

This study shows that GWIC exposure affects mitochondrial function and innate immune signaling in mice, leading to neurocognitive impairments and sex-specific differences.

This study investigates how the TREM2 R47H variant affects immune responses in Alzheimer's disease by comparing gene expression in different patient groups.

This study shows that chronic systemic inflammation in mice leads to brain changes resembling mixed vascular and Alzheimer's disease pathology, including tauopathy and microglial dysfunction.

This study identifies R47H-TREM2 mutation-induced proinflammatory microglial states in human AD and tauopathy mice, showing Akt pathway involvement and potential therapeutic targets.

This study shows that activating Fpr2/3 receptors reduces LPS-induced inflammation in microglia by inhibiting NFκB and promoting resolution.

This study shows that LDE-MTX reduces microglial activation and increases neuronal preservation after experimental cortical stroke in rats.

This study shows that microglial activation in the mPFC increases GABAergic transmission and causes abnormal behavior in mice, which can be mitigated by blocking microglial activation or administering BDNF.

The paper develops a computational systems biology approach to identify novel microglial-specific targets for the phagosome in Alzheimer's disease using integrated transcriptome and genotype data.

This study identifies the role of Arp2/3 and Cyfip1 in regulating microglial dynamics and suggests their involvement in neuropsychiatric diseases.

This study shows 17a-Estradiol reduces neuroinflammation in male mice but not females, with effects mediated by gonadal hormones and region-specific brain changes.

The paper investigates microglial synaptic internalisation in schizophrenia post-mortem brains and finds no differences in microglial activation or pre-synaptic protein levels between schizophrenia and control cases.

This study investigates the role of Cdk5 in microglia under physiological and pathological conditions, finding transcriptional changes but minimal effects on morphology and behavior.

The paper identifies primate-specific astrocyte responses to stroke, showing NogoA limits macrophage infiltration and suggests therapeutic targeting.

This study shows that microglial phagocytosis dysfunction in a genetic epilepsy model is linked to local neuronal activity, suggesting a role for neuronal activity in phagocytosis impairment.

The paper uses DREADD-activated astrocytes and single-cell RNA sequencing to show transcriptomic changes in astrocytes and microglia, highlighting gene pathways involved in neurogenesis and immune responses.