C. Yang

Rapidly induced drug adaptation mediates escape from BRAF inhibition in single melanoma cells

This study tracks single melanoma cells' response to BRAF inhibitors and identifies non-genetic mechanisms enabling rapid drug escape within 3 days of treatment.

A bottom-up approach for the de novo design of functional proteins

This paper introduces a bottom-up method for designing functional proteins tailored to complex motifs, demonstrating their use as biosensors and signaling ligands.

Nrf2 represses ER stress-related ferroptosis in renal carcinoma cells via HO-1

This study shows that Nrf2 represses ER stress-related ferroptosis in renal carcinoma cells through the HO-1 pathway, suggesting it as a potential therapeutic target.

De novo protein design enables precise induction of functional antibodies in vivo

This paper introduces a de novo protein design algorithm called TopoBuilder that generates immunogens inducing precise antibody responses against respiratory syncytial virus in mice and non-human primates.

Measuring protected-area outcomes with leech iDNA: large-scale quantification of vertebrate biodiversity in Ailaoshan reserve

The paper quantifies vertebrate biodiversity in Ailaoshan reserve using leech iDNA, showing species richness increases with elevation and distance from the reserve edge.

Integrin β3, a RACK1 interacting protein, is required for porcine reproductive and respiratory syndrome virus infection and NF-κB activation in Marc-145 cells

This study identifies integrin β3 as a RACK1-interacting protein essential for PRRSV infection and NF-κB activation in Marc-145 cells, revealing a positive feedback loop involving NF-κB and ITGB3/RACK1.

Circadian Rhythm Is Disrupted by ZNF704 in Breast Carcinogenesis

This study identifies ZNF704 as a driver of breast carcinogenesis by disrupting circadian rhythms through repression of PER2 and other clock genes.

The landscape of coadaptation in Vibrio parahaemolyticus

The paper identifies coadapted genetic elements in Vibrio parahaemolyticus through genome-wide screening, revealing complex interactions and ecological strategies.

Resolving cell cycle speed in one snapshot with a live-cell fluorescent reporter

The paper introduces a fluorescent reporter to measure cell cycle speed in single cells using one snapshot, demonstrating its application in hematopoietic cells and solid tissues.

Strain-level differences in gut microbiome composition determine fecal IgA levels and are modifiable by gut microbiota manipulation

The paper identifies Bacteroides ovatus strains that induce IgA production and shows that manipulating these strains can modify gut IgA levels in mice.

Structural and biochemical characterization on the cognate and heterologous interactions of the MazEF-mt9 TA system

This study characterizes the structural and biochemical interactions of the MazEF-mt9 TA system in M. tb, revealing its cognate and heterologous antitoxin binding and its role in stress adaptation.

Bimodal Regulation of the PRC2 Complex by USP7 Underlies Melanomagenesis

This study identifies USP7's dual role in stabilizing EZH2 and facilitating PRC2 chromatin loading, promoting melanoma progression and correlating with poor patient prognosis.

Rapid identification of homozygosity and site of wild relative introgressions in wheat through chromosome-specific KASP genotyping assays

The paper develops chromosome-specific KASP assays to rapidly detect and assess homozygosity of wild relative introgressions in wheat.

Structural determinants of microtubule minus end preference in CAMSAP CKK domains

This study compares human and Naegleria CKK domains to show how structural differences in tubulin conformations enable microtubule minus-end recognition.

METABOLIC DIVERSITY IN HUMAN NON-SMALL CELL LUNG CANCER CELLS

The paper quantifies metabolic features in NSCLC cell lines to explore associations between metabolism and other cell-autonomous processes.

Rare non-synonymous germline mutations systematically define the risk of triple negative breast cancer

This paper identifies rare germline mutations associated with triple-negative breast cancer risk using a machine learning approach and shows improved risk prediction compared to existing methods.

SWITCH 1/DYAD is a novel WINGS APART-LIKE antagonist that maintains sister chromatid cohesion in meiosis

This study identifies SWITCH 1/DYAD as a novel WAPL antagonist in Arabidopsis meiosis that maintains sister chromatid cohesion, showing functional similarity to Sororin despite lacking sequence homology.

Why panmictic bacteria are rare

The paper estimates recombination scaled effective population size in 21 bacterial species and finds only two show signs of panmixia, suggesting panmixia is unstable in bacteria.

Recent mixing of Vibrio parahaemolyticus populations

The paper analyzes genomic data from 1,103 Vibrio parahaemolyticus isolates to show recent genetic mixing among four populations due to increased human-mediated dispersal.

Temporal modulation of host aerobic glycolysis determines the outcome of M. marinum infection

This study shows that pre-infection modulation of host glycolysis with 2-DG enhances resistance to M. marinum infection by reducing phagocytosis and bacterial proliferation.

Access COI barcode efficiently using high throughput Single End 400 bp sequencing

The paper introduces a high-throughput sequencing approach to efficiently generate full-length COI barcodes using SE400 data, achieving high accuracy in species identification.

Environmental DNA for the enumeration and management of Pacific salmon

This study demonstrates that flow-corrected environmental DNA (eDNA) rates can accurately track daily numbers of returning and outmigrating Pacific salmon spawners and smolts.

Boosting subdominant neutralizing antibody responses with a computationally designed epitope-focused immunogen

This study demonstrates that a computationally designed epitope-focused immunogen enhances subdominant neutralizing antibody responses against RSV.

TP promotes malignant progression in hepatocellular carcinoma through pentose Warburg effect

This study shows TP, activated by Twist1, promotes HCC metastasis and VM via pentose Warburg effect by linking pentose phosphate pathway and glycolysis.

Coordinative Metabolism of Glutamine Carbon and Nitrogen in proliferating Cancer Cells Under Hypoxia

The paper identifies a hypoxia-specific metabolic pathway in cancer cells that redirects glutamine nitrogen to secretory dihydroorotate, avoiding ammonia toxicity and supporting tumor growth.

Gut microbiota density influences host physiology and is shaped by host and microbial factors

The paper examines factors influencing gut microbiota density across mammals, disease states, and interventions, finding host and microbial factors shape density and impact health.

Using eDNA to Detect the Distribution and Density of Invasive Crayfish in the Honghe-Hani Rice Terrace World Heritage Site

This study tests eDNA detection for invasive crayfish in rice terraces, finding it more sensitive than trapping and suggesting repeated sampling for reliable monitoring.