D. Li

Accumulation of ammonium owing to the metabolic imbalance of carbon and nitrogen might inhibit the central metabolism in Methylomonas sp. ZR1

This study investigates how ammonium accumulation from nitrogen and carbon metabolism imbalance inhibits growth in Methylomonas sp. ZR1 and identifies strategies to mitigate this inhibition.

Information theory tests critical predictions of plant defense theory for specialized metabolism

The paper uses information theory to test predictions of plant defense theories by analyzing metabolomes across scales in Nicotiana attenuata and related species.

Global post-translational modification profiling of HIV-1-infected cells reveals mechanisms of host cellular pathway remodeling

The paper uses proteomics to analyze PTM changes in HIV-1-infected cells, identifying mechanisms of host pathway remodeling through Aurora kinase A and PP2A modulation.

Endocytic Clathrin Coats Develop Curvature at Early Stages of Their Formation

The paper uses live cell imaging to show clathrin-coated pits develop curvature early without requiring a flat-to-curved transition.

Parkinson's disease associated mutation E46K of α-synuclein triggers the formation of a novel fibril structure

This study determines the cryo-EM structure of a novel α-synuclein fibril formed by the E46K mutation, showing structural changes and altered stability compared to wild-type fibrils.

VIP-producing enteric neurons interact with innate lymphoid cells to regulate feeding-dependent intestinal epithelial barrier functions

This study shows that VIP-producing enteric neurons interact with ILC3 to regulate intestinal barrier functions and nutrient absorption during feeding.

Big data reveals deep associations in physical examination indicators and can help predict overall underlying health status

The paper systematically analyzes correlations between 221 physical examination indicators in healthy and disease states, identifies disease markers, and develops machine learning models to predict health status with high precision.

Protein adlayer thickness on colloidal nanoparticle determined by Rayleigh-Gans-Debye approximation

The paper develops rm-RGDA to in situ measure nanoparticle size and adlayer thickness, showing it aligns with SEM but differs from DLS and provides insights into protein structure changes based on nanoparticle curvature.

Structural characterization of the N-terminal domain of the Dictyostelium discoideum mitochondrial calcium uniporter

This study reports the crystal structure of the N-terminal domain of DdMCU and shows its oligomeric state and calcium-dependent dissociation.

ApoC-III overexpression and LDLr-/- protect mice from DSS-colitis: identifying a new role for lipoprotein metabolism in Tregs

This study shows that apoC-III overexpression and LDLr deficiency protect mice from DSS-colitis by increasing intestinal Tregs and IL-10, suggesting apoC-III as a potential therapeutic target for IBD.

Mechanistic insights into NAD synthase NMNAT chaperoning phosphorylated Tau from pathological aggregation

This study identifies NMNAT as a chaperone that prevents phosphorylated Tau aggregation in vitro and reduces pathology in a fly model.

Effects of Chinese herbal medicine residues on antibiotic resistance genes and the bacterial community in chicken manure composting

This study evaluates how adding Chinese herbal medicine residues affects antibiotic resistance genes and bacterial communities in chicken manure composting, finding increased ARG removal with higher residue addition.

Methods for broad-scale plant phenology assessments using citizen scientists’ photographs

The paper develops best practices for using iNaturalist citizen science data to assess plant flowering phenology, demonstrating its utility for studying unusual flowering events and integrating data into a global knowledge store.

LIN28B-PDZ Binding Kinase Signaling Promotes Neuroblastoma Metastasis

This study identifies LIN28B's role in promoting neuroblastoma metastasis through the regulation of PBK, a kinase that enhances self-renewal and migration.

Human oral microbiome characterization and its association with environmental microbiome revealed by the Earth Microbiome Project

The paper analyzes oral microbiome data from the Earth Microbiome Project to show its distinct composition, lower diversity, and environmental correlations.

3D mapping of host-parasite-microbiome interactions reveals metabolic determinants of tissue tropism and disease tolerance in Chagas disease

This study maps host-parasite-microbiome interactions in Chagas disease, identifying metabolic factors that influence tissue tropism and disease tolerance.

Optical interrogation of sympathetic neuronal effects on macroscopic cardiac monolayer dynamics

This study uses optical methods to investigate how sympathetic neurons affect cardiac monolayer dynamics, focusing on neurotransmitter release, neuronal density effects, and optogenetics applications.

Effects of melatonin on germination and amino acid content in different wheat varieties seeds under polyethylene glycol stress

This study examines how melatonin affects wheat seed germination and amino acid content under PEG stress, finding that 300 μM melatonin improves germination metrics and lysine levels.

BRCA1 Mediated Homologous Recombination and S Phase DNA Repair Pathways Restrict LINE-1 Retrotransposition in Human Cells

This study identifies BRCA1 and other DNA repair factors that suppress LINE-1 retrotransposition in human cells by affecting retrotransposition frequency and ORF2 protein translation.

Serum Amyloid A Proteins Induce Pathogenic TH17 Cells and Promote Inflammatory Disease

This study shows serum amyloid A proteins drive pathogenic TH17 cell differentiation and promote inflammatory disease through STAT3-activating cytokines.

For common community phylogenetic analyses, go ahead and use synthesis phylogenies

This paper compares purpose-built and synthesis phylogenies for community phylogenetic analyses, finding synthesis trees yield comparable results with less effort.

Cyclosporine A Directly Affects Human and Mouse B cell Migration in vitro by Disrupting a HIF-1α Dependent, O2 Sensing, Molecular Switch

This study shows cyclosporine A disrupts a HIF-1α-dependent oxygen sensing switch in B cells, affecting their migration in vitro.

Exogenous Melatonin accelerates seed germination in cotton(Gossypium hirsutum L.)

This study shows that low concentrations of melatonin promote cotton seed germination by enhancing antioxidant enzyme activity, reducing MDA, and modulating plant hormones like ABA and GA3.

Germline genomic patterns are associated with cancer risk, oncogenic pathways and clinical outcomes

This study identifies seven germline genomic patterns associated with cancer risk, oncogenic pathways, and clinical outcomes across 22 cancer types.

High specificity of widely used phospho-tau antibodies validated using a quantitative whole-cell based assay

The paper validates the specificity of phospho-tau antibodies using a flow cytometry assay and finds that some antibodies show significant non-specific binding.

Application of Volumetric Absorptive Micro Sampling to Measure Multidimensional Anti-Influenza Hemagglutinin IgG Antibodies by mPlex-Flu Assay

This paper combines VAMS and mPlex-Flu assays to measure influenza antibody responses, showing high consistency between finger-stick and venous blood samples.

Membrane association of VAMP2 SNARE motif in cells and its regulation by different lipid phases of synaptic vesicle membrane

This study investigates how lipid phases in synaptic vesicle membranes regulate the structure and function of the VAMP2 SNARE motif using in-cell NMR and lipidomic profiling.

Programming conventional electron microscopes for solving ultrahigh-resolution structures of small and macro-molecules

This paper develops a method to use conventional electron microscopes for high-resolution structure determination of small molecules and macromolecules by synchronizing the stage and camera.

Homogenization of species composition and species association networks are decoupled

The paper examines how species composition and species association networks change over time in Wisconsin forests, finding that shifts in associations often exceed those in composition.

Proteomic Profile of TGF-β1 treated Lung Fibroblasts identifies Novel Markers of Activated Fibroblasts in the Silica Exposed Rat Lung

The paper identifies 196 differentially expressed proteins in TGF-β1-treated lung fibroblasts and finds that VLDLR and SDC2 are upregulated in silica-exposed lungs, with knockdown reducing collagen production.