Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
17 papers
Recent·Most cited
R. Romero, T. Chu, T. J. Gonzalez-Robles, P. Smith, Y. Xie, H. Kaur, S. Yoder, H. Zhao, C. Mao, W. Kang, M. Pulina, K. E. Lawrence, A. Gopalan, S. Zaidi, K. Yoo, , C. Sawyers
This study identifies ASCL1 as a critical driver of neuroendocrine lineage transition in prostate cancer using an in vivo model and spatial transcriptomics.
bioRxiv · Apr 9, 2024Cancer Biology
A. W. Daman, A. C. Antonelli, G. Redelman-Sidi, L. Paddock, J. G. Cheong, L. F. Jurado, A. Benjamin, S. Jiang, D. Ahimovic, S. Khayat, M. J. Bale, O. Loutochin, V. A. McPherson, D. Pe'er, M. Divangahi, , M. Glickman
This study shows that bladder BCG immunotherapy reprograms hematopoietic stem cells to enhance anti-tumor immunity in mice and humans.
bioRxiv · Mar 21, 2024 · PreprintImmunology
K. M. Tsanov, F. M. Barriga, Y.-J. Ho, D. Alonso-Curbelo, G. Livshits, R. P. Koche, T. Baslan, J. Simon, S. Tian, A. N. Wuest, W. Luan, J. E. Wilkinson, I. Masilionis, N. Dimitrova, C. A. Iacobuzio-Donahue, , S. W. Lowe
This study shows that metastatic site influences the function of driver genes like SMAD4 in pancreatic cancer, with organ-specific epigenetic states affecting tumor growth.
bioRxiv · Mar 17, 2024 · PreprintCancer Biology
A. Moorman, F. Cambuli, E. Benitez, Q. Jiang, Y. Xie, A. Mahmoud, M. Lumish, S. Hartner, S. Balkaran, J. Bermeo, S. Asawa, C. Firat, A. Saxena, A. Luthra, V. Sgambati, , K. Ganesh
This study identifies progressive plasticity in colorectal cancer metastases, showing reprogramming into fetal progenitor states and divergent differentiation, linked to poor survival.
bioRxiv · Aug 18, 2023Cancer Biology
S. Gan, D. G. Macalinao, S. H. Shahoei, L. Tian, X. Jin, H. Basnet, J. T. Muller, P. Atri, E. Seffar, W. Chatila, A.-K. Hadjantonakis, N. Schultz, E. Brogi, T. A. Bale, D. Pe'er, J. Massague
This study compares the brain metastasis colonization strategies of triple-negative breast cancer and HER2+ breast cancer, revealing distinct tumor architectures and stromal interactions.
bioRxiv · Jan 27, 2023 · PreprintCancer Biology
S. Lowe, F. M. Barriga, K. M. Tsanov, Y. J. Ho, N. Sohail, A. Zhang, T. Baslan, A. N. Wuest, I. Del Priore, B. Meskauskaite, G. Livshits, D. Alonso-Curbelo, J. Simon, A. Chaves-Perez, D. Bar-Sagi, , D. Pe'er
The paper investigates how 9p21.3 deletions in cancer disable both cell intrinsic and extrinsic tumor suppression by co-deleting CDKN2A/B and type I interferons, leading to immune evasion and metastasis.
bioRxiv · Aug 22, 2022 · PreprintCancer Biology
C. Burdziak, D. Alonso-Curbelo, T. Walle, F. M. Barriga, J. Reyes, Y. Xie, Z. Zhao, C. J. Zhao, H.-A. Chen, O. Chaudhary, I. Masilionis, Z.-N. Choo, V. Gao, W. Luan, A. Wuest, , D. Pe'er
The paper uses single-cell analysis to show that epigenetic plasticity and cell-cell interactions drive tissue remodeling in early pancreatic cancer.
bioRxiv · Jul 26, 2022Cancer Biology
R. Niec, T. Chu, S. Gur-Cohen, M. Schernthanner, L. Hidalgo, H. A. Pasolli, R. Kataru, B. Mehrara, D. Pe'er, E. Fuchs
The paper identifies lymphatic-secreted factors that maintain intestinal stem cells and inhibit their premature differentiation through a novel deconvolution algorithm and spatial transcriptomics.
bioRxiv · Jan 29, 2022 · PreprintCell Biology
A. I. Kousa, L. Jahn, K. Zhao, A. E. Flores, D. Granadier, K. Cooper, J. M. Sheridan, A. Lemarquis, L. Sikkema, K. V. Argyropoulos, J. Tsai, A. Lazrak, K. Nichols, N. Lee, R. Ghale, , M. R. van den Brink
The paper identifies age-related thymic epithelial cell states that impair thymic regeneration and immune function through spatial and single-cell transcriptomics.
bioRxiv · Dec 16, 2021Immunology
W. Karthaus, J. Chan, M. Setty, J. Love, S. Zaidi, Z.-N. Choo, S. Persad, J. LaClair, K. Lawrence, O. Chaudhary, T. Xu, I. Masilionis, L. Mazutis, R. Chaligne, D. Pe'er, C. Sawyers
This study identifies a pharmacological strategy to reverse lineage plasticity in prostate cancer by inhibiting FGFR and Janus kinase pathways.
bioRxiv · Nov 1, 2021 · PreprintCancer Biology
S. Zaidi, J. L. Zhao, J. M. Chan, M. P. Roudier, K. M. Wadosky, A. Gopalan, W. R. Karthaus, J. Choi, K. Lawrence, O. Chaudhary, T. Xu, I. Masilionis, L. Mazutis, R. Chaligne, I. Linkov, , C. L. Sawyers
The paper identifies stem-like luminal cells with elevated JAK/STAT signaling as a source of multilineage plasticity in prostate cancer, offering a therapeutic target.
bioRxiv · Nov 1, 2021 · PreprintCancer Biology
M. Dhainaut, S. A. Rose, G. Akturk, A. Wroblewska, E. Sook Park, S. R. Nielsen, M. Buckup, V. Roudko, L. Pia, J. Le Berichel, A. Bektesevic, B. H. Lee, A. Baccarini, N. Bhardwaj, A. H. Rahman, , B. D. Brown
Perturb-map enables spatial CRISPR screening in tumors, identifying genes that regulate immune composition by mapping gene knockouts and their effects on the tumor microenvironment.
bioRxiv · Jul 13, 2021 · PreprintImmunology
J. M. Chan, A. Quintanal-Villalonga, V. Gao, Y. Xie, V. Allaj, O. Chaudhary, I. Masilionis, J. Egger, A. Chow, T. Walle, M. Mattar, D. V. Yarlagadda, J. L. Wang, F. Uddin, M. Offin, , C. M. Rudin
The paper profiles single-cell transcriptomes of SCLC subtypes to identify novel tumor and myeloid subpopulations and their associations with metastasis and immune microenvironment changes.
bioRxiv · Dec 1, 2020Cancer Biology
D. Li, J. L. Chen, Q. Ma, Y. Xie, A. Liu, J. Cheung, H. Gudjonson, T. Nawy, D. Pe'er, I. Pe'er
The paper introduces a generative model to test hypotheses about cell-cell interactions in tumor microenvironments using synthetic multiplexed images.
bioRxiv · Oct 27, 2020 · PreprintCancer Biology
J. C. Schupp, T. S. Adams, C. Cosme, M. S. Brickman Raredon, N. Omote, S. Poli, K.-A. Rose, E. Manning, M. Sauler, G. DeIuliis, F. Ahangari, N. Neumark, Y. Yuan, A. C. Habermann, A. J. Gutierrez, , N. Kaminski
The paper reanalyzes six scRNA-seq datasets to create a comprehensive reference atlas of human lung endothelial cells, identifying new subpopulations and confirming their conservation in mice.
bioRxiv · Oct 21, 2020Cell Biology
A. D. Viny, R. L. Bowman, Y. Liu, V.-P. Lavallee, S. E. Redlich, W. Xiao, B. H. Durham, A. Navitski, J. Park, S. Braunstein, E. Azizi, M. Witkin, T. Baslan, C. J. Ott, D. Pe'er, , R. L. Levine
The paper shows Stag2 loss in HSPCs impairs B-cell lineage commitment by reducing chromatin accessibility, while Stag1 cannot restore this function despite rescuing topological domains.
bioRxiv · Mar 18, 2019 · PreprintCell Biology
E. Azizi, A. J. Carr, G. Plitas, A. E. Cornish, C. Konopacki, S. Prabhakaran, J. Nainys, K. Wu, V. Kiseliovas, M. Setty, K. Choi, R. M. Fromme, P. Dao, P. T. McKenney, R. C. Wasti, , D. Pe'er
The paper maps immune cell phenotypes in breast cancer using single-cell RNA-seq and identifies continuous tumor-specific expansions driven by environmental cues.
bioRxiv · Apr 2, 2018Immunology