D. Wu

Definition and Signatures of Lung Fibroblast Populations in Development and Fibrosis in Mice and Men

This study identifies fibroblast subpopulations in mouse and human lungs using scRNA-seq, revealing conserved transcriptomic signatures and their roles in fibrosis.

Structural insights into the insecticidal Vip3A toxin of Bacillus thuringiensis

This study presents the first crystal structure of the Vip3A toxin, revealing its domain organization and glycan binding specificity, which informs its insecticidal mechanism and potential for improved bio-insecticides.

How to account for the uncertainty from standard toxicity tests in species sensitivity distributions: an example in non-target plants

This paper assesses how uncertainty in ER50 values affects HR5 estimates in SSD analyses for non-target plants using Bayesian and frequentist methods.

Protein enhanced NIR-IIb emission of indocyanine green for functional bioimaging

This study demonstrates that indocyanine green (ICG) emits strong NIR-IIb fluorescence when dissolved in protein solutions, enabling high-resolution bioimaging with improved signal-to-background ratio.

Biologically excretable AIE dots for visualizing through the marmosets intravitally: horizons in future clinical nanomedicine

This study designs excretable AIE dots for deep-tissue imaging in marmosets, demonstrating their biocompatibility and excretion capabilities.

Susceptibility of tree shrew to SARS-CoV-2 infection

This study investigates tree shrew susceptibility to SARS-CoV-2 infection and finds that they show mild symptoms and low viral replication, suggesting limited susceptibility.

Flow-cell based technology for massively parallelcharacterization of base-modified DNA aptamers

This paper introduces a flow-cell based system for high-throughput characterization of base-modified DNA aptamers using a modified Illumina MiSeq instrument.

Correlating glycoforms of DC-SIGN with stability using a combination of enzymatic digestion and ion mobility MS

This study uses mass spectrometry to show that the stability of DC-SIGN is better correlated with the number of glycosylation sites than with glycan mass or length.

Rapid development of an inactivated vaccine for SARS-CoV-2

A purified inactivated SARS-CoV-2 vaccine candidate (PiCoVacc) induces neutralizing antibodies in animals and shows safety and partial to complete protection against SARS-CoV-2 strains.

Comparison of SARS-CoV-2 infections among 3 species of non-human primates

This study compares SARS-CoV-2 infection outcomes in three non-human primate species, finding that M. mulatta is most susceptible, followed by M. fascicularis and C. jacchus.

Structural and Functional NIR-II Fluorescence Bioimaging in Urinary System via Clinically Approved Dye Methylene Blue

This study uses methylene blue for NIR-II fluorescence imaging to enable structural and functional imaging of the urinary system in vivo and preclinical renal function assessment.

Aging immune system-related blood cell DNA methylation can predict the onset of early stage colorectal cancer

This study identifies DNA methylation of DZIP3 as a marker for early stage colorectal cancer, linked to aging and immune cell composition.

Variation in the life history strategy of cells underlies tumor’s functional diversity

This study applies r- and K-selection to HeLa cells to show how life history strategies influence tumor functional diversity through gene expression and ecological competition.

Mitochondria branch within Alphaproteobacteria

The paper investigates the phylogenetic placement of mitochondria within Alphaproteobacteria using alternative methods to address compositional heterogeneity.

Genetically encoded nanostructures enable acoustic manipulation of engineered cells

This paper demonstrates that genetically encoded gas vesicles can be manipulated by ultrasound to control engineered cells.

Rapid discovery of synthetic DNA sequences to rewrite endogenous T cell circuits

This paper develops a platform to discover synthetic DNA sequences that enhance T cell functions by integrating them into endogenous genomic sites.

Integration of pathway, cellular and genetic context reveals principles of synthetic lethality that affect reproducibility

The paper identifies principles for improving synthetic lethality reproducibility by integrating pathway, cellular, and genetic context in KRAS-mutant cells.

Genome-Wide Association Study and Pathway-Level Analysis of Kernel Color in Maize

This study identifies genetic loci associated with maize kernel color through genome-wide association and pathway analysis, highlighting genes involved in carotenoid biosynthesis and retention.

The first genetic linkage map for Fraxinus pennsylvanica and syntenic relationships with four related species

This paper constructs the first genetic linkage map for green ash and identifies syntenic relationships with four related species.

The Growth Hormone Secretagogue Receptor, Ghrelin and Biochemical Signaling Molecules in Human Heart Failure

The paper examines GHSR and ghrelin levels in cardiac tissue from transplant patients to assess their correlation with heart failure markers and function.

Extracellular Degradation into Adenosine and the Activities of Adenosine Kinase and AMPK Mediate Extracellular NAD+-produced increases in the Adenylate Pool of BV2 Microglia under Basal Conditions

Accurate Immune Repertoire Sequencing Reveals Malaria Infection Driven Antibody Lineage Diversification in Young Children

The paper introduces a high-coverage antibody repertoire sequencing method, MIDCIRS, and uses it to show increased somatic hypermutation in infants and toddlers during malaria infection.

Glycolytic reliance promotes anabolism in photoreceptors

This study shows that rod photoreceptors use glycolysis for outer segment biogenesis and that FGF signaling regulates this process to support anabolic needs.