D. Wu

Ion currents through Kir potassium channels are gated by anionic lipids.

The paper shows anionic lipids gate potassium conduction through Kir channels by interacting with the internal gate via fatty acyl tails.

Structural basis for recognition of two HLA-A2-restricted SARS-CoV-2 spike epitopes by public and private T cell receptors

The paper determines the structural basis for recognition of two SARS-CoV-2 spike epitopes by T cell receptors, revealing insights into epitope specificity and variation.

Imaging biological samples by integrated differential phase contrast (iDPC) STEM technique

This study demonstrates that iDPC-STEM provides superior contrast and structural detail in biological samples compared to conventional TEM, especially at low doses and for thick sections.

Small-molecule cocktails induce the differentiation of human adipose-derived mesenchymal stem cells into hepatocyte-like cells

This study induces human adipose-derived mesenchymal stem cells into hepatocyte-like cells using small-molecule cocktails and growth factors, producing cells with mature phenotype and function.

One mucosal administration of a live attenuated recombinant COVID-19 vaccine protects non-human primates from SARS-CoV-2

This study shows that a single mucosal dose of the live attenuated RSV-based vaccine MV-014-212 protects non-human primates from SARS-CoV-2 infection by reducing viral shedding and inducing neutralizing antibodies.

Improved Metabolite Prediction Using Microbiome Data-Based Elastic Net Models

The paper develops ENVIM, an Elastic Net Model-based method for predicting metabolites from microbiome data, showing improved accuracy over existing methods in oral, gut, and vaginal microbiome datasets.

Somatic mutations of activated signaling genes, transcription factors, or tumor suppressors are a precondition for leukemic transformation from myelodysplastic syndromes: a sequencing analysis of 64 paired samples

Ultrafast amplitude modulation for molecular and hemodynamic ultrasound imaging

This paper introduces an ultrafast nonlinear ultrasound imaging technique that improves sensitivity, field of view, and frame rate for molecular and hemodynamic imaging.

A generalized kinetic model describes ion-permeation mechanisms in various ion channels

This paper introduces a generalized kinetic model to describe ion-permeation mechanisms in ion channels using patch-clamp data.

The Impact of Control Interface on Features of Heart Rate Variability

This study examines how different control interfaces affect the validity and reliability of using heart-rate variability features to monitor mental workload during powered wheelchair operation.

Endothelial restoration of CAD GWAS gene PLPP3 by nanomedicine suppresses YAP/TAZ activity and reduces atherosclerosis in vivo

This paper develops a nanomedicine approach to restore PLPP3 in endothelial cells, reducing YAP/TAZ activity and atherosclerosis in mice.

Diverse Hotspot Thermal Profiling Methods Detect Phosphorylation-Dependent Changes in Protein Stability

The paper compares two HTP methods, finding that LFE-HTP improves proteoform coverage and detects novel phosphorylation sites affecting protein stability.

Quantatitive Analysis of Conserved Sites on the SARS-CoV-2 Receptor-Binding Domain to Promote Development of Universal SARS-Like Coronavirus Vaccines

The paper identifies conserved antigenic sites in SARS-CoV-2 and SARS-CoV RBDs and designs RBD variants to improve immunogenicity for universal vaccine development.

Unbalanced dietary patterns contribute to the pathogenesis of precocious puberty by affecting gut microbiota and host metabolites

This study identifies unbalanced dietary patterns as contributors to precocious puberty by altering gut microbiota and host metabolites, with biomarkers showing high diagnostic accuracy.

Taking full advantage of modelling to better assess environmental risk due to xenobiotics

The paper reviews dose-response models and introduces MOSAIC, a tool for environmental risk assessment using TKTD models to improve pesticide risk evaluation for aquatic organisms.

Apoptotic Extracellular Vesicles (ApoEVs) Safeguard Liver Homeostasis and Regeneration via Assembling an ApoEV-Golgi Organelle

This study shows that apoptotic extracellular vesicles (apoEVs) protect liver homeostasis and regeneration by forming a chimeric organelle with the Golgi apparatus and restoring hepatic ploidy.

Rapid Characterization of AAV gene therapy vectors by Mass Photometry

This paper demonstrates that mass photometry can rapidly and accurately characterize rAAV vectors by resolving capsid populations and quantifying full and empty capsids.

Energetic and structural features of SARS-CoV-2 N-protein co-assemblies with nucleic acids

This study investigates how SARS-CoV-2 N-protein interacts with nucleic acids to form supramolecular clusters and phase-separated droplets, revealing structural and energetic changes during assembly.

SARS-CoV-2 infection reduces Krüppel-Like Factor 2 in human lung autopsy

This study shows that SARS-CoV-2 infection reduces KLF2 in human lung autopsies, linking KLF2 down-regulation to vascular dysfunction in ARDS.

MEMS directed evolution of two cytochrome P450 enzymes revealing distinct active-sites for convergent function

This study introduces a multi-enzyme directed evolution model to improve screening throughput and efficiency, revealing convergent evolution in two cytochrome P450 enzymes with distinct active sites achieving similar functions.

First demonstration of the FLASH effect with ultrahigh dose-rate high-energy X-rays

This paper demonstrates the first use of high-energy X-rays in FLASH radiotherapy, showing effective tumor control and tissue protection in mice.

Keratin-Based Epidermal Green Autofluorescence is a Common Biomarker of Organ Injury

This study identifies keratin 1-based epidermal green autofluorescence as a biomarker for non-invasive assessment of inflammation and oxidative stress levels in the body.

Dysregulation of Pulmonary Responses in Severe COVID-19

The paper reanalyzes a single-cell RNA-Seq dataset to identify cellular and molecular differences in severe versus mild COVID-19, suggesting potential biomarkers for disease severity.

Proteomics study of colorectal cancer and adenomatous polyps identifies TFR1, SAHH, and HV307 as potential biomarkers for screening

This study identifies TFR1, SAHH, and HV307 as potential biomarkers for colorectal cancer screening through proteomics analysis of pre-cancerous to cancerous tissues.

Identify potent SARS-CoV-2 main protease inhibitors via accelerated free energy perturbation-based virtual screening of existing drugs

This paper identifies potent SARS-CoV-2 main protease inhibitors using accelerated free energy perturbation-based virtual screening of existing drugs, finding 15 inhibitors from 25 predicted drugs.

Polo-like kinase 1 independently controls microtubule-nucleating capacity and size of the centrosome

This study shows that Polo-like kinase 1 directly controls microtubule-nucleating sites on centrosomes, independent of centrosome size, and is critical for spindle assembly.

A targetable epigenetic vulnerability in PI3K/AKT inhibitor resistant cancers

This study identifies an epigenetic vulnerability in PI3K/AKT inhibitor-resistant cancers, showing that targeting bromodomain or HDAC inhibitors can overcome resistance by modulating histone acetylation at growth factor/receptor gene loci.

Identification of microbial markers across populations in early detection of colorectal cancer

The paper identifies microbial markers for early colorectal cancer detection across populations using meta-analysis and classifier models, achieving high diagnostic accuracy.

Alterations in bile acid metabolizing gut microbiota and specific bile acid genes as a precision medicine to subclassify NAFLD

The paper identifies bile acid metabolizing microbes and genes associated with NAFLD subtypes using metagenomic data and develops a classifier model for NAFLD detection.

Rbx1 Cullin-Ring ligase E3 and Ube2m neddylation E2 differentially governs the fitness of Treg cells

This study shows Rbx1 and Ube2m differentially regulate Treg cell homeostasis and function, with Rbx1 deletion causing severe inflammation and Ube2m deletion causing milder issues, suggesting therapeutic potential for targeting neddylation/CRLs in immune disorders.