J. Sun

Quasi-Equilibrium State Based Quantification of Biological Macromolecules in Single-Molecule Localization Microscopy

This paper introduces a method to precisely quantify molecular stoichiometry in vivo using single-molecule localization microscopy by analyzing fluorophore detections during the quasi-equilibrium state.

Differential cellular immune responses against Orientia tsutsugamushi Karp and Gilliam strains following acute infection in mice

This study compares immune responses in mice infected with two Orientia tsutsugamushi strains, showing differential cellular activation and cytokine profiles linked to disease severity.

A deep learning-based drug repurposing screening and validation for anti-SARS-CoV-2 compounds by targeting the cell entry mechanism

This study uses deep learning to screen FDA-approved drugs and TCM compounds for anti-SARS-CoV-2 activity by targeting cell entry, identifying several effective candidates.

Covalent targeting as a common mechanism for inhibiting NLRP3 inflammasome assembly.

This study identifies covalent compounds that inhibit NLRP3 inflammasome assembly by targeting reactive cysteines, suggesting NLRP3 as an electrophile sensor for inflammatory signaling.

Spatio-temporal variation of bacterial community structure in two intertidal sediment types of Jiaozhou Bay

This study examines bacterial community structure in intertidal sediments of Jiaozhou Bay, finding that sandy sediments have more species involved in community building and that temporal changes have a greater impact on bacterial communities than on gene families.

Drosophila AHR limits tumor growth and stem cell proliferation in the intestine

This study shows that Spineless, the Drosophila AHR homolog, limits tumor growth and stem cell proliferation in the adult intestine by regulating gene expression and metabolism.

Nuclear bodies protect phase separated proteins from degradation in stressed proteome

The paper uses imaging methods to study how nuclear bodies protect TDP-43 from degradation during stress by monitoring its folding states in live cells.

Sterile Soil as Prebiotics Mitigate Intergenerational Loss of Gut Microbial Diversity and Anxiety-Like Behavior Induced by Antibiotics in mice

This study shows that sterile soil prebiotics can restore gut microbial diversity and alleviate anxiety-like behavior and intestinal barrier issues caused by antibiotic exposure across generations in mice.

ANKRD49 promotes the metastasis of NCI-H1299 and NCI-H1703 cells via activating JNK-ATF2/c-Jun-MMP-2/9 axis

This study shows ANKRD49 promotes metastasis in NSCLC cells by activating the JNK-ATF2/c-Jun-MMP-2/9 pathway.

Adaptive-learning physics-aware light-field microscopy enables day-long and millisecond-scale super-resolution imaging of 3D subcellular dynamics

This paper introduces Alpha-LFM, a physics-aware deep learning framework for 3D super-resolution imaging of living cells, achieving high resolution, speed, and low phototoxicity over long periods.

Urine proteomic characterization of active and recovered COVID-19 patients

This study characterizes urine proteomic changes in active and recovered COVID-19 patients, identifying persistent immune and metabolic alterations and potential biomarkers.

CLE11 and CLE10 Suppress Mycorrhizal Colonisation in Tomato

This study identifies SlCLE10 and SlCLE11 as CLE peptides that suppress arbuscular mycorrhizal colonisation in tomato roots, with SlCLE11 acting locally and SlCLE10 showing a minor or redundant role.

Mechanism of outer membrane destabilization by global reduction of protein content

This study investigates how reducing outer membrane protein content in Gram-negative bacteria weakens the outer membrane, alters cell shape, and causes rupture by disrupting lipid asymmetry.

MiR-302-Induced anti-aging neural stem cells enhance cognitive function and extend lifespan

This study reprograms human fibroblasts into anti-aging neural stem cells using miR-302a, which enhance cognitive function and extend lifespan in mice with Alzheimer's.

Mono-ADP-ribosyltransferase 1 (Artc1)-deficiency decreases tumorigenesis, increases inflammation, decreases cardiac contractility, and reduces survival

Homocysteine accelerates hepatocyte autophagy by upregulation of TFEB via DNMT3b-mediated DNA hypomethylation

This study shows homocysteine increases hepatocyte autophagy by upregulating TFEB through DNMT3b-mediated DNA hypomethylation of the TFEB promoter.

PI(3,5)P2 Controls the Signaling Activity of Class I PI3K

This study identifies PI(3,5)P2 as a regulator of Class I PI3K activity by interacting with its p85 subunit, revealing a feedback mechanism that impacts cancer and tissue repair.

Aspartyl protease in the secretome of honey bee trypanosomatid parasite is essential for the efficient infection of host

The paper identifies the exoproteome of the honey bee trypanosomatid parasite Lotmaria passim and shows that an aspartyl protease is essential for efficient infection of the host.

RNA sequencing identifies lung cancer lineage and facilitates drug repositioning

This paper uses RNA sequencing to classify lung cancer subtypes and identifies drug repositioning opportunities based on lineage-specific responses.

Hepatocyte-specific miR-33 deletion attenuates NAFLD-NASH-HCC progression

This study shows that deleting miR-33 in hepatocytes reduces NAFLD progression to NASH, fibrosis, and HCC by improving lipid metabolism and mitochondrial function.

Alterations in Germinal Center Formation and B Cell Activation during Severe Orientia tsutsugamushi Infection in Mice

This study investigates B cell and germinal center (GC) responses in mice infected with Orientia tsutsugamushi, finding disrupted GC formation and reduced B cell activation at later stages of infection.

A cinnamyl alcohol dehydrogenase (CAD) like enzyme leads to a branch in the shikonin biosynthetic pathway in Arnebia euchroma

This study identifies AeHGO, a CAD-like enzyme, as the branch point enzyme in the shikonin biosynthetic pathway of A. euchroma, showing it catalyzes reversible oxidation/reduction of key intermediates.

Engineering and characterization of carbohydrate-binding modules to enable real-time imaging of cellulose fibrils biosynthesis in plant protoplasts

This study engineers and characterizes tandem carbohydrate-binding modules (CBMs) to enable real-time imaging of cellulose fibril biosynthesis in Arabidopsis protoplasts.

Molecular insights into the gating mechanisms of voltage-gated calcium channel CaV2.3

This study determines the cryo-EM structure of human CaV2.3 channels and identifies key residues and interactions involved in channel gating and inactivation.

Phylogenomic analyses shed light on the relationships of chiton superfamilies and shell-eye evolution

The paper uses genome and transcriptome data to resolve the phylogeny of chitons, supporting that shell eyes originated in Schizochitonoidea and evolved secondarily in other genera.

Arabidopsis ORP2A positively regulates glucose signaling by interacting with AtRGS1 and promoting AtRGS1 degradation

PlantServation: time-series phenotyping using machine learning revealed seasonal pigment fluctuation in diploid and polyploid Arabidopsis

PlantServation uses machine learning to analyze field images and estimate anthocyanin content in Arabidopsis, revealing seasonal fluctuations influenced by environmental factors.

O-GlcNAcylation promotes YTHDF1 cytosolic localization and colorectal cancer tumorigenesis

This study shows O-GlcNAcylation of YTHDF1 enhances its cytosolic localization and promotes colorectal cancer by increasing c-Myc expression.

Confocal reflectance microscopy for mapping collagen fiber organization in the vitreous gel of the eye

This study uses confocal reflectance microscopy to map collagen fiber organization in porcine vitreous, revealing fiber density variations and poor alignment.

Discovery of benzophenanthridine derivatives with potent activity against multidrug resistant Mycobacterium tuberculosis

This study identifies two benzophenanthridine derivatives with potent anti-Mtb activity, effective against multidrug-resistant strains and comparable to rifampicin.