L. Lu

Arl15 upregulates the TGFβ family signaling by promoting the assembly of the Smad-complex

This study identifies Arl15 as a regulator of TGFβ signaling by promoting Smad-complex assembly through its interaction with Smad4.

pVHL regulates protein stability of TCF/LEF transcription factor family via ubiquitin-independent proteasomal degradation

This study shows pVHL regulates TCF/LEF protein stability via ubiquitin-independent proteasomal degradation, revealing a novel mechanism in Wnt/β-catenin signaling.

Integrated phylogenomics and fossil data illuminate the evolution of beetles

This paper integrates phylogenomic data and fossil records to refine the evolutionary timescale and classification of beetles, revealing a late Carboniferous origin and Cretaceous diversification.

Copper(II) Gluconate Boosts the Anti-SARS-CoV-2 Effect of Disulfiram in Vitro

This paper shows that combining disulfiram and copper(II) gluconate significantly enhances anti-SARS-CoV-2 activity in vitro compared to either compound alone.

Lupus Gut Microbiota Transplants Cause Autoimmunity and Inflammation

This study shows that transferring gut microbiota from SLE patients to germ-free mice induces lupus-like features, suggesting a causal role for gut microbiota in SLE pathogenesis.

Adaptation, spread and transmission of SARS-CoV-2 in farmed minks and related humans in the Netherlands

This study investigates SARS-CoV-2 transmission between minks and humans in the Netherlands, finding that some mutations led to faster and wider spread among mink farms.

Potential transmission chains of variant B.1.1.7 and co-mutations of SARS-CoV-2

The paper analyzes SARS-CoV-2 mutations and co-mutations, suggesting Canidae as a possible host for the B.1.1.7 variant and showing that co-mutations significantly reduce viral replication.

DEPDC1/ EEF1A1 complex promotes the progression of human osteosarcoma via downregulation of FOXO3a

This study identifies the DEPDC1-EEF1A1-FOXO3a axis as a critical pathway promoting osteosarcoma progression by downregulating FOXO3a, with implications for therapeutic strategies.

Fine-tuning of SUMOylation modulates drought tolerance

This study shows that both increased and decreased SUMOylation enhance drought tolerance in apple by modulating MdDREB2A stability through SUMOylation and ubiquitination.

SUMOylation of GMFB regulates the stability and function of GMF in RPE cells under oxidative stress and inflammation

This study shows SUMOylation of GMFB increases its stability and trans-localization, upregulating inflammatory pathways in RPE cells under oxidative stress and inflammation.

Apoptotic Extracellular Vesicles (ApoEVs) Safeguard Liver Homeostasis and Regeneration via Assembling an ApoEV-Golgi Organelle

This study shows that apoptotic extracellular vesicles (apoEVs) protect liver homeostasis and regeneration by forming a chimeric organelle with the Golgi apparatus and restoring hepatic ploidy.

A quantitative study of the Golgi retention of glycosyltransferases

This study quantitatively examines how glycosyltransferases remain in the Golgi by analyzing their post-Golgi trafficking and identifying retention mechanisms through chimeric protein analysis.

Human antibody immune responses are personalized by selective removal of MHC-II peptide epitopes

The paper shows that MHC-II epitope removal from BCRs correlates with antibody development, T cell help, and long-term serum antibody secretion.

Interactions between strains govern the eco-evolutionary dynamics of microbial communities

The paper tracks microbial communities over generations to show that strain-level interactions drive eco-evolutionary dynamics, with fine-scale genetic differences affecting community behavior.

Public good exploitation in natural bacterioplankton communities

The paper develops a genomic approach to identify public good exploiters in marine microbial communities degrading chitin, showing their activity and potential impact on polysaccharide degradation.

Epithelial colonies in vitro elongate through collective effects

This study investigates how epithelial colonies elongate in vitro, finding that global elongation results from cell elongation or oriented neighbor exchange depending on external stimuli.

Plant endophytic bacteria: a potential resource pool of electroactive microorganisms

This study isolates and evaluates electroactive endophytic bacteria from plant tissues, identifying strains with potential for microbial fuel cells.

Flexible and transparent silver nanowire structures for multifunctional electrical and optical biointerfacing

This paper develops flexible, transparent silver nanowire microelectrodes for multifunctional biointerfacing, showing high optical transparency, low impedance, and good biocompatibility in heart monitoring.

Discovery and Development of Human SARS-CoV-2 Neutralizing Antibodies using an Unbiased Phage Display Library Approach

This study identifies and develops human SARS-CoV-2 neutralizing antibodies using a phage display library, showing their efficacy in vivo against the virus.

Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide

This study evaluates enzalutamide's antiviral efficacy against SARS-CoV-2 in different cell types and mouse models, finding it effective in prostate cancer cells but not in lung cells or organoids.

Engineered Trimeric ACE2 Binds and Locks "Three-up" Spike Protein to Potently Inhibit SARS-CoVs and Mutants

This study engineers a trimeric ACE2 protein that binds the spike protein with high affinity, inhibiting SARS-CoVs and mutants by locking the spike in a 'three-up' conformation.

When and why an essential popular mineral-calcium-is an effective antifungal adjuvant against the human pathogen?

This study shows that exogenous calcium is toxic to fungal cells lacking calcineurin, a key calcium regulator, and that this toxicity is linked to cytosolic calcium overload and vacuolar storage deficits.

Genetic signatures for lineage/sublineage classification of HPV16, 18, 52 and 58 variants

The paper identifies genetic signatures for classifying HPV16, 18, 52, and 58 variants into lineages/sublineages with high accuracy using publicly available genomes.

How to quantitatively measure, assess and correct the fluorescence crosstalk in the wide-field microscopy

The paper introduces a quantitative metric and protocol to measure and correct fluorescence crosstalk in wide-field microscopy using common image processing software.

Glycans function as a Golgi export signal to promote the constitutive exocytic trafficking

The paper shows that O- and N-glycans act as signals for Golgi export, affecting the trafficking of transmembrane proteins.

Single-cell RNA-sequencing of peripheral neuroblastic tumors reveals an aggressive transitional cell state at the junction of an adrenergic-mesenchymal transdifferentiation trajectory

This study uses single-cell RNA-sequencing to identify a transitional cell state in peripheral neuroblastic tumors associated with poor prognosis and therapeutic targets.

De Novo Assembly of the Northern Cardinal (Cardinalis cardinalis) Genome Reveals Candidate Regulatory Regions for Sexually Dichromatic Red Plumage Coloration

This paper presents a high-quality genome assembly of the Northern Cardinal and identifies candidate regulatory regions associated with red plumage coloration and sexual dichromatism.

Evaluating rehabilitation progress using motion features identified by machine learning

This paper uses machine learning to identify motion features for evaluating rehabilitation progress in stroke patients, finding that movement smoothness is the best measure.

Fully human single-domain antibodies against SARS-CoV-2

This paper develops fully human single-domain antibodies against SARS-CoV-2 and identifies their neutralizing activity and immunogenic profile compared to SARS-CoV and MERS-CoV.

Inhibition of SARS-CoV-2 infection (previously 2019-nCoV) by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion

This paper identifies EK1C4, a potent fusion inhibitor against SARS-CoV-2 and other coronaviruses, showing high efficacy in vitro and in vivo.