M. Yang

In the absence of reproductive isolation - Extensive gene flow after speciation

The paper sequenced two mangrove species to show extensive gene flow after speciation, with many small introgression blocks and genomic islets contributing to speciation.

A tandem-repeat dimeric RBD protein-based COVID-19 vaccine ZF2001 protects mice and nonhuman primates

ZF2001, a tandem-repeat dimeric RBD protein vaccine, induces strong immune responses and protects mice and non-human primates from SARS-CoV-2 infection.

Engineering the Immune Adaptor Protein STING as a Biologic

This study engineers the STING protein as a delivery system to enhance CDN delivery and restore STING signaling in cancer cells.

MMP12 Knockout Prevent Weight and Muscle Loss Induced by Cancer Cachexia

This study shows that MMP12 knockout prevents weight and muscle loss in ApcMin/+ mice with cancer cachexia by disrupting insulin and glycolipid metabolism.

Lipidomic analysis of roseobacters of the pelagic RCA cluster and their response to phosphorus limitation

This study reports lipidomic analysis of six RCA roseobacter isolates, revealing unique phospholipid synthesis and adaptation to phosphorus limitation.

Structural Basis of Complex Formation Between Mitochondrial Anion Channel VDAC1 and Hexokinase-II

This study investigates the structural basis of the HKII/VDAC1 complex formation using simulations and electrophysiological measurements, revealing partial blockade of VDAC1 and phosphorylation-dependent disruption of binding.

Transcriptome Profiling of different types of human respiratory tract cells infected by SARS-CoV-2 Highlight an unique Role for Inflammatory and Interferon Response

This study identifies 36 upregulated genes across SARS-CoV-2-infected respiratory tract cells, highlighting inflammatory and interferon response pathways linked to cytokine storms in severe COVID-19.

Transferrin receptor is another receptor for SARS-CoV-2 entry

This study identifies the transferrin receptor (TfR) as an additional receptor for SARS-CoV-2 entry, showing that TfR-mediated infection can occur independently of ACE2 and that targeting TfR has anti-viral effects.

Genome sequencing sheds light on the contribution of structural variants to Brassica oleracea diversification

This study identifies structural variants in Brassica oleracea genomes that contribute to morphological divergence between cauliflower and cabbage.

A non-canonical EZH2 function sensitizes solid tumors to genotoxic stress

This study shows EZH2 inhibitors inhibit CRPC growth by downregulating DNA repair genes, making cancer cells more sensitive to genotoxic stress.

Control of ss-glucan exposure by the endo-1,3-glucanase Eng1 in Candida albicans modulates virulence

This study shows that Eng1 and Ywp1 in C. albicans reduce Dectin-1 binding by masking β-glucans, thereby decreasing immune recognition and virulence.

Airway epithelial integrin β4 suppresses allergic inflammation by decreasing CCL17 production

This study shows that ITGB4 in airway epithelial cells reduces CCL17 production, thereby suppressing Th2 responses and allergic inflammation in asthma.

Susceptibility of tree shrew to SARS-CoV-2 infection

This study investigates tree shrew susceptibility to SARS-CoV-2 infection and finds that they show mild symptoms and low viral replication, suggesting limited susceptibility.

Rapid development of an inactivated vaccine for SARS-CoV-2

A purified inactivated SARS-CoV-2 vaccine candidate (PiCoVacc) induces neutralizing antibodies in animals and shows safety and partial to complete protection against SARS-CoV-2 strains.

Direct Metatranscriptome RNA-seq and Multiplex RT-PCR Amplicon Sequencing on Nanopore MinION - Promising Strategies for Multiplex Identification of Viable Pathogens in Food

Comparison of SARS-CoV-2 infections among 3 species of non-human primates

This study compares SARS-CoV-2 infection outcomes in three non-human primate species, finding that M. mulatta is most susceptible, followed by M. fascicularis and C. jacchus.

Pancreatlas: applying an adaptable framework to map the human pancreas in health and disease

Pancreatlas provides a web resource for exploring annotated human pancreas images, integrating multiple imaging technologies into an adaptable framework for data access and analysis.

An Improved 4'-Aminomethyltroxsalen-Based DNA Crosslinker for Biotinylation of DNA

The paper introduces a novel DNA crosslinker, AP3B, which is significantly more effective than the commercial EZ-Link Psoralen-PEG3-Biotin in labeling DNA in cells and crosslinking DNA strands in vitro.

Polyploidization enhancing genetic recombination of the ancestral diploid genome in the evolution of hexaploid wheat

This study shows that hexaploidization in wheat enhances genetic recombination of the ancestral diploid genome, increasing evolutionary potential and aiding wheat's global spread.

The Pathogenicity of SARS-CoV-2 in hACE2 Transgenic Mice

This study infects hACE2 transgenic mice with SARS-CoV-2 and observes pathogenic effects, confirming Koch's postulates and establishing a model for vaccine and therapeutic development.

Alteration of fecal microbial compositions and bacterial taxa in female osteoporotic patients

The paper compares fecal microbial compositions between female osteoporotic patients and healthy controls, identifying bacterial taxa associated with osteoporosis and demonstrating predictive power using a random forest model.

Genomic and protein structure modelling analysis depicts the origin and infectivity of 2019-nCoV, a new coronavirus which caused a pneumonia outbreak in Wuhan, China

The paper analyzes the genomic and protein structure of 2019-nCoV to determine its origin and infectivity, finding it is a bat coronavirus with weak human ACE2 receptor binding.

Streptococcus pyogenes Cas9 displays biased one-dimensional diffusion on dsDNA to search for a target

This study shows that Cas9 uses biased one-dimensional diffusion along dsDNA to efficiently locate its target, with diffusion length quantified at 27 bp.

Voltage-dependent activation of Rac1 by Nav1.5 channels promotes cell migration

The paper shows Nav1.5 channels depolarize the membrane potential, increasing Rac1 activation and promoting cell migration.

Diverse, abundant and novel viruses infecting \"unculturable\" but abundant marine bacteria

The paper isolates and characterizes seven phages infecting Roseobacter RCA lineage bacteria, revealing genomic diversity and abundance in marine virosphere.

GDF15 and the beneficial actions of metformin in pre-diabetes

This study shows metformin increases GDF15 levels, which is necessary for its weight loss and insulin-sensitizing effects in both humans and mice.

Dynamic Changes of G-CSF etc. Nine Cytokines in Mouse Bloodstream Infection Models of Staphylococcus aureus and Klebsiella pneumoniae and their Clinical Performances

This study monitors cytokine dynamics in mouse infection models and evaluates their diagnostic performance for bacterial bloodstream infections.

Metastatic breast cancer cells induce altered microglial morphology and electrical excitability in vivo

This study shows metastatic breast cancer cells alter microglial morphology and electrical activity in the brain, contributing to seizures and cognitive issues.

Rare non-synonymous germline mutations systematically define the risk of triple negative breast cancer

This paper identifies rare germline mutations associated with triple-negative breast cancer risk using a machine learning approach and shows improved risk prediction compared to existing methods.

Red and black: A β-carotene-binding protein carrying a red pigment regulates body-color transition in locusts

This study identifies a β-carotene-binding protein that regulates body color transition in locusts by modulating red pigment accumulation.