M. Yang

ATG5- and ATG7-mediated autophagy regulates pollen tube guidance and male fertility in Arabidopsis thaliana

Genetic disruption of isocitrate dehydrogenase arrests the full development of sexual stage parasites in Plasmodium falciparum

This study shows that knocking out isocitrate dehydrogenase (IDH) in Plasmodium falciparum parasites arrests gametocyte development, similar to aconitase knockout, and suggests IDH as a potential target for malaria transmission control.

Machine Learning Informs RNA-Binding Chemical Space

This study introduces ROBIN, a large RNA-binding small molecule library, and uses machine learning to model RNA-binding chemical space.

Anti-apoptotic BH3-only proteins inhibit Bak

The paper identifies BNIP5 and Bcl-G as anti-apoptotic BH3-only proteins that inhibit Bak activation, preventing apoptosis.

FOXA2 controls the anti-oxidant response in FH-deficient cells

This study identifies FOXA2 as a key transcription factor regulating the anti-oxidant response in FH-deficient cells, independent of NRF2, and highlights its role in metabolic rewiring.

A Novel Selective ERK1/2 Inhibitor, Laxiflorin B, Targets EGFR Mutation Subtypes in Non-small-cell Lung Cancer

This study identifies Laxiflorin B, a novel ERK1/2 inhibitor, showing efficacy against EGFR mutant NSCLC through apoptosis induction and suppression of AREG/EREG.

Fbxo7 promotes Cdk6 activity to inhibit PFKP and glycolysis in T cells.

This study identifies Fbxo7's role in promoting Cdk6 activity to inhibit PFKP and glycolysis in T cells, revealing its impact on metabolism and viability.

HIRA loss transforms FH-deficient cells

This study identifies HIRA depletion as a factor that enhances proliferation and invasion of Fh1-deficient cells, revealing a mechanism involving MYC activation and nucleotide metabolism.

Orchestration of alternative splicing regulates bone marrow mesenchymal stem cells fate during aging

This study identifies YBX1 deficiency causes mis-splicing in BMSCs, leading to senescence and bone loss, and shows Sciadopitysin can reverse this process.

Structural basis of a two-antibody cocktail exhibiting highly potent and broadly neutralizing activities against SARS-CoV-2 variants including diverse Omicron sublineages

This study identifies two broadly neutralizing antibodies against SARS-CoV-2 variants and shows their synergistic neutralization effect, supported by cryo-EM structures.

Loss-of-function mutation in human Oxidation Resistance gene 1 disrupts the spatial-temporal regulation of histone arginine methylation in early brain development

This study identifies a loss-of-function mutation in OXR1 causing neurodevelopmental disorders and shows its role in regulating histone arginine methylation in brain organoids.

3'UTR-directed, kinase proximal mRNA decay inhibits C/EBPβ phosphorylation/activation to suppress senescence in tumor cells

This study identifies a mechanism where 3'UTR-directed mRNA decay inhibits C/EBPβ activation, suppressing senescence in tumor cells and promoting tumor progression.

Global Spatial Transcriptome of Macaque Brain at Single-Cell Resolution

The paper creates a 3-D cell type atlas of the monkey brain using single-cell spatial transcriptomics and identifies molecular markers for neocortical layers and subregions.

Biochemical analysis challenging Western blot analysis as validation step for antibodies intended for ELISA and immunohistochemistry

The study compares antigen-antibody interactions at different states using QDB, showing conformational epitopes dominate interactions, challenging Western blot as a validation tool for IHC and ELISA antibodies.

Preclinical Pharmacokinetics and In Vitro Properties of GS-441524, A Potential Oral Drug Candidate for COVID-19 Treatment

This study examines the preclinical pharmacokinetics and in vitro ADME properties of GS-441524, showing its stability across species and varying bioavailability, supporting its development as an oral drug candidate for COVID-19.

Novel MBLs inhibitors screened from FDA-approved drug library restore the susceptibility of carbapenems to NDM-1-harbouring bacteria

The paper screens FDA-approved drugs to find inhibitors of NDM-1, restoring carbapenem efficacy against resistant bacteria.

Barley stripe mosaic virus γb protein targets thioredoxin h-type 1 to dampen SA-mediated antiviral defenses

The paper shows that BSMV γb protein targets NbTRXh1 to reduce its reductase activity, impairing SA defense gene expression and enhancing viral movement.

Structural and functional characterizations of altered infectivity and immune evasion of SARS-CoV-2 Omicron variant

The paper characterizes structural and functional changes in the SARS-CoV-2 Omicron variant's Spike protein, identifying new immune escape sites and providing insights for vaccine development.

Biogenesis of a bacterial metabolosome for propanediol utilization

This study investigates the biogenesis of propanediol-utilization metabolosomes in bacteria, revealing both 'Shell first' and 'Cargo first' assembly pathways.

Direct Imaging and Identification of Proteoforms up to 70 kDa from Human Tissue

This paper introduces PiMS, a method that detects proteoforms up to 70 kDa in human tissue with high spatial resolution, identifying key metabolic enzymes in kidney tissue.

Immune, endothelial and neuronal network map in human lymph node and spleen

The paper maps immune, endothelial, and neuronal networks in human spleen and lymph node using multiplex imaging, revealing novel cellular localization patterns.

Macrophage Innate Training Induced by IL-4 and IL-13 Activation Enhances OXPHOS Driven Anti-Mycobacterial Responses

This study shows that IL-4 and IL-13 activation of macrophages induces protective innate memory against mycobacterial infection through enhanced OXPHOS-driven pro-inflammatory responses.

Tuning the sensitivity of genetically encoded fluorescent potassium indicators through structure-guided and genome mining strategies

The paper develops genetically encoded fluorescent potassium indicators with tunable binding affinities through structure-guided design and genome mining, showing varying Kd values in vitro and in cells.

Streptococcus pneumoniae rapidly translocates from the nasopharynx through the cribriform plate to invade and inflame the dura

This study shows Streptococcus pneumoniae rapidly translocates from the nose through the cribriform plate to the meninges without entering the bloodstream.

Zika virus causes placental pyroptosis and associated adverse fetal outcomes by activating GSDME

This study shows that Zika virus causes placental pyroptosis via GSDME activation, leading to adverse fetal outcomes.

Nitrogen partitioning between branched-chain amino acids and urea cycle enzymes sustains renal cancer progression

This study identifies metabolic reprogramming in renal cancer cells, showing how branched-chain amino acid catabolism and urea cycle enzymes support tumor progression and metastasis.

Nanobody-Functionalized Cellulose for Capturing and Containing SARS-CoV-2

This paper develops a cellulose-based method using nanobodies to capture and neutralize SARS-CoV-2 pseudoviruses, showing effectiveness against wildtype and D614G variants.

Ribosomal protein L23 drives the metastasis of hepatocellular carcinoma via upregulating MMP9

This study identifies ribosomal protein L23 as a driver of hepatocellular carcinoma metastasis by upregulating MMP9 expression and promoting tumor growth and metastasis in vivo.

Disruption of the TCA cycle reveals an ATF4-dependent integration of redox and amino acid metabolism

This study investigates the effects of TCA cycle inhibition on redox and amino acid metabolism, revealing ATF4-dependent metabolic rewiring and distinct responses between FH and SDH inhibition.

Perinatal maternal chronic exposure to dibutyl phthalate promotes visceral obesity in adult female offspring

This study shows that maternal exposure to dibutyl phthalate during pregnancy and lactation leads to increased visceral obesity in adult female offspring without affecting serum glucolipid levels or the PI3K/AKT pathway in muscle.