P. Sharma

Distinct Mechanisms of Innate and Adaptive Immune Regulation Underlie Poor Oncologic Outcomes Associated with KRAS-TP53 Co-Alteration in Pancreatic Cancer

SARS-CoV-2 and its variants, but not Omicron, induces thymic atrophy and impaired T cell development

This study shows SARS-CoV-2 and its variants cause thymic atrophy and impair T cell development, with Omicron having a lesser effect than Delta.

The role of floral traits in community assembly process at high elevations in Lesser Himalaya

This study examines how floral traits influence plant community assembly along an elevation gradient in the Lesser Himalaya, finding that abiotic factors and pollinator interactions shape floral trait composition.

A molecular dynamics study of antimicrobial peptide translocation across the outer membrane of Gram-negative bacteria

This study uses molecular dynamics simulations to analyze the translocation mechanism of the antimicrobial peptide CM15 across the outer membrane of E. coli, revealing key structural and energetic features of the process.

Elucidating Collective Translocation of Nanoparticles Across the Skin Lipid Barrier: A Molecular Dynamics Study

This study uses molecular dynamics simulations to examine nanoparticle translocation through skin lipid membranes, finding coated nanoparticles more efficiently traverse double bilayer models than bare particles.

Avobenzone, Guaiazulene and Tioxolone identified as potent autophagy inducers in a high-throughput image based screen for autophagy flux

The paper identifies Avobenzone, Guaiazulene, and Tioxolone as potent autophagy inducers through a high-throughput image-based screen using a GFP-LC3-RFP reporter system in A375 cells.

RICTOR Drives ZFX-mediated Ganglioside Biosynthesis to Promote Breast Cancer Progression.

This study identifies RICTOR's role in regulating ganglioside biosynthesis via ZFX and UGCG, promoting breast cancer progression through EGFR signaling.

SARS-CoV-2 Omicron-B.1.1.529 Variant leads to less severe disease than Pango B and Delta variants strains in a mouse model of severe COVID-19

This study compares the severity of SARS-CoV-2 Omicron-B.1.1.529, Pango B, and Delta variants in a mouse model, finding Omicron causes less severe disease with lower viral load and inflammation.

Single-dose immunisation with a multimerised SARS-CoV-2 receptor binding domain (RBD) induces an enhanced and protective response in mice

This paper demonstrates that a multimerised SARS-CoV-2 RBD vaccine using a stable scaffold provides enhanced antibody responses and complete protection in mice.

Particle Uptake Driven Phagocytosis in Macrophages and Neutrophils Enhances Bacterial Clearance

This study shows that non-stimulatory cargo-free particles enhance phagocytic ability in macrophages and neutrophils, leading to faster bacterial clearance.

Keratin 19 interacts with GSK3β to regulate its nuclear accumulation and degradation of cyclin D3

This study shows that keratin 19 interacts with GSK3β to inhibit its nuclear accumulation and prevent cyclin D3 degradation, affecting cell proliferation and CDK4/6 inhibitor sensitivity.

Temporal regulation of Pten is essential for retina regeneration in zebrafish

This study shows that Pten downregulation is essential for zebrafish retina regeneration by promoting Muller glia-derived progenitor cell proliferation through Akt and Mmp9/Notch pathways.

Interactions of surfactants with the bacterial cell wall and inner membrane: Revealing the link between aggregation and antimicrobial activity

This study investigates how surfactants interact with bacterial cell walls and membranes, showing that laurate is more effective than oleate in disrupting bacterial membranes and inducing aggregation.

Use of Induced Pluripotent Stem Cells to Build Isogenic Systems and Investigate Type 1 Diabetes

This paper demonstrates the use of induced pluripotent stem cells to create an isogenic system for studying genetic influences on cell-cell interactions in type 1 diabetes.

Neuroinvasion and neurotropism by SARS-CoV-2 variants in the K18-hACE2 mouse

This study investigates SARS-CoV-2 variant neuroinvasion in K18-hACE2 mice, finding CNS spread in all variants except Omicron, with microglial activation and immune cell apoptosis observed.

Immunophenotyping and transcriptional profiling of human plasmablasts in dengue.

This study characterizes plasmablasts in dengue patients from India, showing their transcriptional features, adhesion molecule expression, and differential expansion based on infection severity.

Experimental evidence pointing to rain as a reservoir of tomato phyllosphere microbiota

The paper tests if rain is a reservoir of tomato phyllosphere microbiota by comparing microbial communities on rain-exposed and protected tomato leaves.

Phagocytic Uptake of Polymeric Particles by Immune cells Under Flow Conditions

This study shows that immune cells can phagocytose polymeric particles under flow conditions, similar to or better than static conditions, with implications for particle design.

Naturally-acquired immunity in Syrian Golden Hamsters provides protection from re-exposure to emerging heterosubtypic SARS-CoV-2 variants B.1.1.7 and B.1.351

This study shows that prior SARS-CoV-2 infection in Syrian Golden Hamsters protects against re-exposure to variants B.1.1.7 and B.1.351, suggesting immunity may limit disease from emerging variants.

Endothelial alpha globin is a nitrite reductase

This study shows endothelial alpha globin functions as a nitrite reductase to mediate hypoxia-induced vasodilation in resistance arteries.

Convergent evolution of resistance pathways during early stage breast cancer treatment with combination cell cycle (CDK) and endocrine inhibitors

This study examines how breast cancer tumors evolve during early stage treatment with combination CDK and endocrine inhibitors, finding convergent resistance pathways and increased subclonal diversity with combination therapy.

Design of novel Cyanovirin-N variants by modulation of binding dynamics through distal mutations

The paper introduces an ICDC approach to identify distal mutations that modulate protein function through dynamic allostery, validated on TEM-1 β-lactamase and applied to Cyanovirin-N.

Evaluating coarse-grained MARTINI force-fields for capturing the ripple phase of lipid membranes

This study evaluates MARTINI force-fields for simulating the ripple phase of lipid membranes, finding that they fail to capture the phase at larger system sizes due to kinetic trapping and require re-parametrization.

Evidence for co-evolution of masking and circadian phase in Drosophila melanogaster

This study shows that artificial selection in Drosophila melanogaster led to early chronotypes with enhanced masking and advanced entrainment phases, suggesting masking contributes to circadian phasing.

Sequential infection with influenza A virus followed by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) leads to more severe disease and encephalitis in a mouse model of COVID-19.

This study shows that sequential infection with influenza A virus followed by SARS-CoV-2 in mice leads to more severe disease and encephalitis compared to single infections.

Microbiome-Gut-Brain-Axis communication influences metabolic switch in the mosquito Anopheles culicifacies

This study shows that the gut microbiome influences brain function and metabolic changes in mosquitoes through a microbiome-gut-brain axis.

Direct shoot regeneration from cotyledon, leaf and root of Citrus jambhiri Lush.

This study demonstrates direct shoot regeneration from cotyledons, leaves, and roots of Citrus jambhiri using tissue culture techniques, with varying success rates and plantlet health outcomes.

Single-cell Characterization of Acute Myeloid Leukemia and its Microenvironment Following PD-1 Blockade Based Therapy

This study analyzes single-cell RNA and TCR profiles from AML patients before and after PD-1 blockade therapy to identify factors influencing response and resistance.

Integrated genomic view of SARS-CoV-2 in India

The paper analyzes SARS-CoV-2 genomic data from India to trace introduction and local transmission, identifying multiple clades and highlighting the need for molecular surveillance.

Developing a Coarse-Grained Model for Bacterial Cell Walls and Evaluating Mechanical Properties and Free Energy Barriers

This paper develops a coarse-grained MARTINI model for peptidoglycan and evaluates its mechanical properties and free energy barriers for small molecule insertion.