Q. Yu

Extracellular histones stimulate collagen expression and potentially promote liver fibrogenesis via TLR4-MyD88 signalling pathway

This study shows extracellular histones stimulate collagen production in liver fibrosis via TLR4-MyD88 signaling, and NAHP reduces fibrosis by neutralizing histones.

The human cytomegalovirus protein UL116 interacts with the viral ER resident glycoprotein UL148 and promotes the incorporation of gH/gL complexes into virions

This study identifies UL116 as a chaperone for gH that promotes gH/gL complex expression and virion incorporation, interacting with UL148 to support viral entry mechanisms.

The mutability of demographic noise in microbial range expansions

This study measures how single gene deletions in E. coli affect demographic noise during range expansions, finding that mutations can reduce noise and enhance beneficial mutation establishment.

Integrative Analysis the characterization of peroxiredoxins in pan-cancer

This study systematically analyzes peroxiredoxins (PRDXs) across 33 cancer types, examining expression, genetic alterations, methylation, prognosis, pathways, and drug targets, with validation of PRDX6's role in bladder cancer cell proliferation via JAK2-STAT3 pathway.

Genetically Determined Strength of Natural Killer Cells is Enhanced by Adaptive HLA class I Admixture in East Asians

The paper shows that East Asian populations, particularly the Chinese Southern Han, have enhanced NK cell strength due to genetic admixture and natural selection of HLA class I alleles that interact with inhibitory KIR receptors.

An Antioxidant Enzyme Therapeutic for COVID-19

This paper describes a catalase-based therapeutic for COVID-19 that reduces oxidative stress and cytokine production in human and animal models without toxicity.

Trade-Offs between Speed, Accuracy, and Dissipation in tRNAIle Aminoacylation

This study uses a stochastic model to analyze how tRNAIle aminoacylation balances speed, accuracy, and energy dissipation in E. coli, revealing an economic proofreading strategy that optimizes performance under tolerable error rates.

The insulin receptor adaptor IRS2 is an APC/C substrate that promotes cell cycle protein expression and a robust spindle assembly checkpoint

This study identifies IRS2 as an APC/C substrate, showing it regulates cell cycle protein expression and the spindle assembly checkpoint.

Polymorphisms in Human Cytomegalovirus gO Exert Epistatic Influences on Cell-Free and Cell-To-Cell Spread, and Antibody Neutralization on gH Epitopes.

This study shows how variations in the gO protein of HCMV affect viral spread and antibody neutralization, with effects influenced by genetic background.

Bacillus subtilis spore induces efficient generation of memory T cells via ICAM-1 expression on dendritic cells

This study shows that Bacillus subtilis spore enhances mucosal immunity by promoting intestinal-resident memory T cells through ICAM-1 expression on dendritic cells.

Specialization for cell-free or cell-to-cell spread of BAC-cloned HCMV strains is determined by factors beyond the UL128-131 and RL13 loci.

This study shows HCMV strains can specialize in cell-free or cell-to-cell spread, with these traits determined by factors beyond the UL128-131 and RL13 loci.

CsHscB as a novel TLR2 agonist from carcinogenic liver fluke Clonorchis sinensis modulates host immune response

The paper identifies CsHscB from Clonorchis sinensis as a TLR2 agonist that modulates macrophage activation and IL-10 production through TLR2-dependent mechanisms.

Existence and functions of hypothalamic kisspeptin neuropeptide signaling system in a non-chordate deuterostome species

This study identifies and characterizes the kisspeptin system in the sea cucumber Apostichopus japonicus, revealing its existence and function in a non-chordate species.

Antibody-free enzyme-assisted chemical labeling for detection of transcriptome-wide N6-methyladenosine

This paper introduces an antibody-free method for transcriptome-wide m6A detection using FTO-assisted chemical labeling, showing good sensitivity and overlap with antibody-based results.

Defining and targeting adaptations to oncogenic KRASG12C inhibition using quantitative temporal proteomics

This study uses quantitative temporal proteomics to analyze KRASG12C inhibitor responses in cancer models, identifying effective drug combinations to overcome resistance.

Study of the AMP-activated protein kinase role in energy metabolism changes during the postmortem aging of yak longissimus lumborum

This study investigates how AMPK activity and energy metabolism change in yak muscle during postmortem aging using AICAR and STO-609.

Full-featured, real-time database searching platform enables fast and accurate multiplexed quantitative proteomics.

The paper introduces a real-time database search platform, Orbiter, that improves the efficiency and accuracy of multiplexed quantitative proteomics by reducing data acquisition time and increasing protein quantification.

Synthetic lethality targeting LKB1 mutant and EGFR wild type human non-small cell lung cancer cells by glucose starvation and SGLT2 inhibition

This study identifies glucose starvation and SGLT2 inhibition as synthetic lethal strategies for EGFR-WT/LKB1-mutant NSCLC, showing efficacy in xenograft models.

The gut microbiota regulates mouse biliary regenerative responses

This study shows that gut microbiota influences biliary regenerative responses in mice, with butyrate playing a role in inhibiting fibrosis.

CryoEM structures of MDA5-dsRNA filaments at different stages of ATP hydrolysis

This paper determines cryoEM structures of MDA5-dsRNA filaments at different ATP hydrolysis stages, revealing how ATPase activity influences filament twist, RNA binding, and signaling.

Endodermal differentiation is reconstructed by coordination of two parallel signaling systems derived from the stele in roots

The paper demonstrates that SHR and stele-derived small peptides coordinate to rebuild functional Casparian strips in non-endodermal cells through two parallel signaling systems.