T. Jiang

Comparative transcriptome analysis reveals the intensive early-stage responses of host cells to SARS-CoV-2 infection

This study compares the early host responses to SARS-CoV-2, SARS-CoV, and MERS-CoV infections using transcriptome analysis, revealing distinct patterns of cytokine and antiviral gene expression.

The potential function of forehead gland secretions in conflict resolution of the male Great Himalayan leaf-nosed bats

This study identifies the role of forehead gland secretions in conflict resolution among male Great Himalayan leaf-nosed bats through chemical analysis and behavioral experiments.

The study of lumbar ligamentum flavum hypertrophy induced in bipedal mice

This study induces bipedal posture in mice to create a model of lumbar ligamentum flavum hypertrophy and shows increased stress leads to degeneration.

MGMT genomic rearrangements contribute to chemotherapy resistance in gliomas

This study shows that MGMT genomic rearrangements cause TMZ resistance in gliomas and can be detected in exosomes as potential recurrence markers.

Proteasome activator PA200 maintains stability of histone marks during transcription and aging

This study shows that PA200 maintains histone mark stability during transcription and aging by promoting acetylation-dependent degradation of core histones.

Tracking crystallophore nucleating properties: setting-up a database for statistical analysis.

The paper introduces a database to analyze the nucleating properties of Crystallophore proteins and compares Tb-Xo4 with Lu-Xo4 for improved phasing.

CM93, a novel covalent small molecule inhibitor targeting lung cancer with mutant EGFR

The paper develops CM93, a novel EGFR inhibitor with improved targeting and brain penetration, showing better efficacy and safety in mouse models of EGFR-mutant NSCLC and brain metastases.

Mutations, Recombination and Insertion in the Evolution of 2019-nCoV

The paper analyzes 120 SARS-CoV-2 genomes to identify genetic subgroups, recombination events, and a unique spike protein insertion that may enhance infectivity.

Nucleosomal embedding reshapes the dynamics of abasic sites

This study uses molecular dynamics simulations to show how AP sites in nucleosomal DNA exhibit distinct dynamics and increased DNA-protein cross-link formation compared to tetrahydrofuran analogs.

Glutamate dehydrogenase (Gdh2)-dependent alkalization is dispensable for escape from macrophages and virulence of Candida albicans

This study shows that Gdh2-dependent alkalization is not required for C. albicans to escape macrophages or maintain virulence, challenging the existing model of amino acid catabolism in phagosomes.

Structural characterization of an intermediate reveals a unified mechanism for the CLC Cl-/H+ transport cycle

The paper presents a 2.6 Å structure of a CLC mutant, revealing a global conformational change that supports a unified transport mechanism for CLC proteins.

Direct comparison of clathrin-mediated endocytosis in budding and fission yeast reveals conserved and evolvable features

This study compares clathrin-mediated endocytosis in budding and fission yeast, finding conserved mechanisms and species-specific adaptations in actin assembly and membrane invagination.

From phages to mammalian viruses: viral receptors play a central role in protein-protein interaction network

The paper curates a database of phage-host receptor interactions and finds that viral receptors, both in phages and mammalian viruses, are central in host protein-protein interaction networks.

A Network of Phosphatidylinositol 4,5-bisphosphate Binding Sites Regulate Gating of the Ca2+-activated Cl- Channel ANO1 (TMEM16A)

This study identifies three PI(4,5)P2 binding sites on ANO1 that allosterically regulate its Ca2+-activated Cl- channel gating through molecular dynamics and electrophysiology.

Branched-Chain Amino Acid Metabolic Reprogramming Orchestrates Drug Resistance to EGFR Tyrosine Kinase Inhibitors

This study identifies BCAT1-mediated metabolic reprogramming as a mechanism of EGFR TKI resistance in lung cancer and shows that combining TKI with ROS-inducing agents can overcome resistance.

Genetic determinants in Salmonella enterica serotype Typhimurium required for overcoming stressors in the host environment

This study identifies 339 conditionally essential genes in S. Typhimurium required for survival under various host stressors using Tn-seq.

Direct control of shell regeneration by the mantle tissue in the pearl oyster Pinctada fucata via accelerating CaCO3 nucleation

This study shows that mantle tissue retraction and dislocation in Pinctada fucata directly control shell regeneration by accelerating CaCO3 nucleation through increased shell matrix protein expression.

Homologous Recombination as an Evolutionary Force in African Swine Fever Viruses

This study analyzes ASFV genomes to show that homologous recombination contributes to genetic diversity through indels, with conserved enzymes involved in recombination.

Identification of genome-wide nucleotide sites associated with mammalian virulence in influenza A viruses

This study identifies genome-wide nucleotide sites associated with mammalian virulence in influenza A viruses and develops machine-learning models to predict virulence.

Membrane proteins with high N-glycosylation, high expression, and multiple interaction partners were preferred by mammalian viruses as receptors

The paper curates a database of virus-host receptor interactions and identifies common features of viral receptors, showing their role in cross-species transmission.

A Highly Efficient and Faithful MDS Patient-Derived Xenotransplantation Model for Pre-Clinical Studies

This paper develops a novel MDS patient-derived xenotransplantation model in MISTRG mice that faithfully represents all MDS subtypes and enables effective drug testing.

An Adaptive Geometric Search Algorithm for Macromolecular Scaffold Selection

This paper introduces an adaptive geometric search algorithm for macromolecular scaffold selection, improving efficiency in matching functional motifs to protein surfaces.