X. Pan

Inhibition of aryl hydrocarbon receptor signaling promotes the terminal differentiation of human erythrocytes

This study shows that inhibiting AHR signaling enhances terminal differentiation of human erythrocytes by promoting F-actin remodeling and cytoskeleton maturation.

Transferrin receptor (Tfr1) ablation in satellite cells impacts skeletal muscle regeneration through the activation of ferroptosis

Conditional Tfr1 ablation in satellite cells causes ferroptosis, leading to skeletal muscle regeneration defects and labile iron accumulation, recapitulated in aged rodents.

Structure of SOQ1 lumenal domains identifies potential disulfide exchange for negative regulation of photoprotection, qH

This study reports the crystal structures and biochemical characterization of SOQ1 lumenal domains, revealing their structural organization and potential regulatory mechanisms in suppressing qH.

Structural basis of LhcbM5-mediated state transitions in green algae

The paper reports high-resolution structures of PSI-LHCI-LHCII supercomplex in green algae, revealing the role of LhcbM5 in state transitions and supercomplex formation.

Structure of human Nav1.5 reveals the fast inactivation-related segments as a mutational hotspot for the Long QT Syndrome

The paper presents the cryo-EM structure of the human Nav1.5-E1784K variant and identifies a mutational hotspot in fast inactivation segments linked to LQT3.

Molecular mechanism underlying the non-essentiality of Bub1 for the fidelity of chromosome segregation in human cells

This study shows Bub1 and the CENP-U complex redundantly recruit Plk1 to kinetochores, ensuring accurate chromosome segregation, and suggests potential therapeutic targets for cancer cells with Bub1 or CENP-U mutations.

De novo protein fold families expand the designable ligand binding site space

The paper constructs a library of ligand binding sites and shows de novo protein scaffolds expand the designable ligand binding site space compared to natural scaffolds.

Paired heavy and light chain signatures contribute to potent SARS-CoV-2 neutralization in public antibody responses

This study identifies a public antibody class, IGHV3-53/3-66, with potent SARS-CoV-2 neutralization capabilities through paired heavy and light chain interactions.

Necrotizing enterocolitis-induced systemic immune suppression in neonatal preterm pigs

This study shows that necrotizing enterocolitis (NEC) in preterm pigs leads to systemic immune suppression, increasing susceptibility to secondary infections.

Ceftazidime Is a Potential Drug to Inhibit SARS-CoV-2 Infection In Vitro by Blocking Spike Protein-ACE2 Interaction

This study identifies ceftazidime as a drug that inhibits SARS-CoV-2 infection by blocking the spike protein-ACE2 interaction in vitro, with an IC50 below therapeutic blood concentrations.

Gluconeogenic Enzyme PCK1 Deficiency Is Critical for CHK2 O-GlcNAcylation and Hepatocellular Carcinoma Growth upon Glucose Deprivation

This study shows that PCK1 deficiency increases O-GlcNAcylation and promotes HCC growth under glucose deprivation by enhancing CHK2 activity.

Oxidations and amino acid substitutions in urinary proteins are the distinguishing characteristics of aging

This study identifies multi-site oxidations and amino acid substitutions in urinary proteins as age-related features by comparing three age groups using mass spectrometry and statistical analysis.

SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damage and constitutes an antiviral target

This study shows the SARS-CoV-2 envelope protein causes ARDS-like damage and identifies channel inhibitors as potential antiviral targets.

Structure-Based Design with Tag-Based Purification and In-Process Biotinylation Enable Streamlined Development of SARS-CoV-2 Spike Molecular Probes

The paper develops biotin-labeled SARS-CoV-2 spike molecular probes using structure-based design and purification methods, achieving high yields and enabling antibody characterization.

Chloroquine and hydroxychloroquine as ACE2 blockers to inhibit viropexis of 2019-nCoV Spike pseudotyped virus

This study investigates whether chloroquine and hydroxychloroquine inhibit 2019-nCoV infection by blocking ACE2 binding, showing both drugs suppress virus entry into ACE2-expressing cells.

Fecal filtrate transfer protects against necrotizing enterocolitis in preterm pigs

This study shows that fecal filtrate transfer prevents necrotizing enterocolitis in preterm pigs without side effects, while fecal microbiota transplantation does not.

Broad-spectrum antivirals of protoporphyrins inhibit the entry of highly pathogenic emerging viruses

This study identifies a protoporphyrin derivative that inhibits entry of enveloped viruses by targeting viral lipids, showing broad antiviral activity in vitro and in vivo.

Expanding the space of protein geometries by computational design of de novo fold families

A computational method expands the structure space of designer proteins by systematically sampling loop-helix-loop geometries.

Organic manure managements increases soil microbial community structure and diversity in double-cropping paddy field of Southern China

The study shows that organic manure and rice straw residue increase soil microbial diversity and abundance in double-cropping paddy fields compared to chemical fertilizer alone or no fertilizer.

Immunoglobulin fragment F(ab')2 against RBD potently neutralizes SARS-CoV-2 in vitro

This study produces and tests an F(ab')2 fragment against SARS-CoV-2 RBD, showing potent in vitro neutralization with an EC50 of 0.07 g/ml.

Urine proteome changes in an α-synuclein transgenic mouse model of Parkinson's disease

The paper analyzes urine proteome changes in α-synuclein transgenic mice to identify proteins associated with Parkinson's disease progression.

Dynamic changes in the urine proteome of tumor-bearing mouse models of B16 melanoma and RM-1 prostate cancer

The paper identifies differential proteins in urine of tumor-bearing mice, showing early biomarker potential for melanoma and prostate cancer.

Global chemical modifications comparison of human plasma proteomes from two different age groups

This study compares global chemical modifications in human plasma proteomes between young and old age groups, identifying four significant differences in modifications such as succinylation, phosphorylation, and carbamylation.

Tracing the origin of a new organ by inferring the genetic basis of rumen evolution

The paper investigates the genetic basis of rumen evolution by comparing transcriptomes and genomic data across ruminants, camels, and cetaceans, identifying key genetic innovations.

The insert sequence in SARS-CoV-2 enhances spike protein cleavage by TMPRSS

This study identifies an insertion sequence in SARS-CoV-2 spike protein that enhances cleavage efficiency and expands tissue tropism beyond the lungs.

Structural basis for pore blockade of the human cardiac sodium channel Nav1.5 by tetrodotoxin and quinidine

The paper presents cryo-EM structures of Nav1.5 bound to tetrodotoxin and quinidine, revealing mechanisms of pore blockade and disease mutation mapping.

In-Depth Characterization and Validation in BRG1-Mutant Lung Cancers Define Novel Catalytic Inhibitors of SWI/SNF Chromatin Remodeling

This study validates novel BRM/BRG1 ATPase inhibitors as chemical probes for SWI/SNF chromatin remodeling and shows their therapeutic potential in BRG1-mut lung cancers.

Structural studies of the Tudor domain from the Bombyx homolog of Drosophila PAPI: Implication to piRNA biogenesis

The paper presents crystal structures of the Tudor domain of BmPAPI to understand its role in piRNA processing.

Arginine-GlcNAcylation of death domain and NleB/SseK proteins is crucial for bacteria pathogenesis by regulating host cell death

This study identifies arginine-GlcNAcylation as a mechanism by which bacterial effectors NleB and SseKs modulate host death receptor signaling to promote pathogenesis.

Auxin-induced nanoclustering of membrane signaling complexes underlies cell polarity establishment in Arabidopsis

This study shows auxin induces TMK1 nanoclustering and lipid nanodomains, which, with microtubule feedback, establish cell polarity in Arabidopsis.