Y. Ding

Systematic mining and functional analysis of factors regulating wheat spike development for breeding selection

This study identifies regulators of wheat spike development through multi-omic analysis and GWAS, revealing novel transcription factors that influence spike architecture and flowering time.

Characterization of TelE, an LXG effector exhibiting a conserved C-terminal glycine zipper motif required for toxicity

The paper identifies and characterizes TelE, an LXG effector from SGG with pore-forming activity, showing its toxicity and requirement for a conserved glycine zipper motif.

Reconstitution of a minimal ESX-5 type VII secretion system suggests a role for PPE proteins in outer membrane transport of proteins

The paper reconstitutes the ESX-5 T7SS in Mycobacterium smegmatis to show that PPE proteins localize to the outer membrane and are required for active secretion.

ATF3 Preserves Skeletal Muscle Stem Cell Quiescence by Preventing Precocious Activation

This study identifies ATF3 as a key regulator that preserves skeletal muscle stem cell quiescence by preventing premature activation and maintaining genome stability.

Extensive plant use of exometabolites

The paper uses 13C-tracing to study plant uptake of exometabolites across multiple species, finding that uptake accounts for 23% of the carbon budget in Brachypodium distachyon and that some metabolites promote root growth.

Respiratory mucosal vaccination of peptide-poloxamine-DNA nanoparticles provides complete protection against lethal SARS-CoV-2 challenge

This study shows that peptide-poloxamine-DNA nanoparticles provide complete protection against lethal SARS-CoV-2 challenge through robust mucosal immunity.

Cytokinin oxidase/dehydrogenase family genes exhibit functional divergence and overlap in rice growth and development, especially in control of tillering

This study investigates the functional roles of OsCKX genes in rice by generating mutants, revealing functional overlap and subfunctionalization, and identifying gene expression changes related to auxin and cytokinin pathways.

Fish oil Nano-emulsion Kills Macrophage: Ferroptosis and Autophagy Triggered by Catalase-catalysed Superoxide Eruption

The paper shows fish oil nano-emulsions trigger ferroptosis and autophagy in macrophages via catalase-catalyzed superoxide production, leading to oxidative damage.

A snapshot of the root phenotyping landscape in 2021

This paper surveys the current state of root phenotyping, identifying key trends, challenges, and needs in the field.

Harringtonine has the effects of double blocking SARS-CoV-2 membrane fusion

This study shows Harringtonine inhibits SARS-CoV-2 membrane fusion by targeting both the viral S protein and host TMPRSS2, effectively blocking infection in delta and Omicron variants.

Multiscale 3D Genome Reorganization during Skeletal Muscle Stem Cell Lineage Progression and Muscle Aging

This study maps 3D genome reorganization during skeletal muscle stem cell activation, proliferation, and aging using Hi-C, revealing how chromatin architecture influences gene expression and lineage progression.

Identification of a promiscuous conserved CTL epitope within the SARS-CoV-2 spike protein

The paper identifies a conserved CTL epitope in the SARS-CoV-2 spike protein that is compatible with most HLA alleles and suitable for evaluating CD8+ T cell responses.

An individualized causal framework for learning intercellular communicationnetworks that define microenvironments of individual tumors

The paper develops a causal framework to identify tumor-specific intercellular communication networks in head and neck squamous cell carcinoma, revealing subtype-specific patterns linked to clinical outcomes.

Dual Recognition of Multiple Signals in Bacterial Outer Membrane Proteins Enhance Assembly and Maintain Membrane Integrity

The paper identifies an additional signal in bacterial outer membrane proteins that enhances assembly efficiency and maintains membrane integrity through interaction with BamD.

Metabolite profiling reveals organ-specific flavone accumulation in Scutellaria and identifies a scutellarin isomer isoscutellarein 8-O-β-glucuronopyranoside

This study profiles flavone accumulation in seven Scutellaria species, revealing organ-specific patterns and identifying a rare 4-hydroxyflavone isomer in some species.

Stromal-cell deletion of STAT3 protects mice from kidney fibrosis by inhibiting pericytes trans-differentiation and migration

This study shows that deleting STAT3 in stromal cells prevents kidney fibrosis by blocking pericyte trans-differentiation and migration.

Comparison of Wild Type DNA Sequence of Spike Protein from SARS-CoV-2 with Optimized Sequence on The Induction of Protective Responses Against SARS-Cov-2 Challenge in Mouse Model

This study compares a wild-type SARS-CoV-2 spike protein DNA vaccine with an optimized sequence in a mouse model, showing enhanced immune responses and protection against viral challenge.

Evidence for the Presence of Hyphae and Fruiting Body Calcium Oxalate Crystallites in Schizophyllum commune

The paper examines S. commune fruiting bodies and hyphae to confirm the presence of calcium oxalate crystallites, demonstrating biomineralization in this fungus.

Notch-Induced Endoplasmic Reticulum-Associated Degradation Governs Thymocyte β-Selection

This study identifies ERAD as a proteostasis checkpoint during β-selection, showing Sel1l deficiency causes ER stress and apoptosis, impairing β T cell development.

A Novel Art of Electrocardiogram Assessment in Zebrafish for Cardiovascular Disease Studies and Drug Screening

This study develops a novel ECG monitoring system for zebrafish to assess cardiovascular function and drug effects, showing improved efficiency and reduced side effects.

Rapid determination of the wide dynamic range of SARS-CoV-2 Spike T cell responses in whole blood of vaccinated and naturally infected

This study evaluates a rapid whole blood test for measuring SARS-CoV-2 Spike-specific T cell responses in vaccinated and infected individuals, finding a wide dynamic range independent of neutralizing antibodies.

Mitogen-activated protein kinases contribute to temperature induced cardiac remodelling in rainbow trout (Oncorhynchus mykiss) heart

This study investigates how temperature affects cardiac remodeling in rainbow trout, finding sex-specific changes in MAPK phosphorylation during cold and warm acclimation.

Kaposi's Sarcoma-associated Herpesvirus vFLIP Promotes MEndT to Generate Hybrid M/E State for Tumorigenesis

This study shows KSHV infection of MSCs drives MEndT to generate hybrid M/E state cells, which are tumorigenic and recapitulate KS features, with vFLIP as a key regulator.

Integration of embryo-endosperm interaction into a holistic and dynamic picture of seed development using a rice mutant with notched-belly grains

The paper investigates embryo-endosperm signaling in rice using a mutant to identify regulatory pathways affecting endosperm development and proposes a new staging system for rice seed development.

Kaposi's Sarcoma-associated Herpesvirus Promotes Mesenchymal-to-Endothelial Transition by Resolving the Bivalent Chromatin of PROX1 Gene

This study shows KSHV resolves the bivalent chromatin of PROX1 to activate its expression, promoting MEndT and tumorigenic features in MSCs.

Focused Ultrasound Modulation of Hepatic Neural Plexus Restores Glucose Homeostasis in Diabetes

The paper demonstrates that focused ultrasound activation of the hepatic neural plexus restores glucose homeostasis in diabetes models across multiple species.

Combinatorial interactions between viral proteins expand the functional landscape of the viral proteome

This study shows that viral proteins interact combinatorially, leading to new biological functions beyond their individual roles during infection.

Screening of HLA-A restricted T cell epitopes of SARS-CoV-2 and induction of CD8+ T cell responses in HLA-A transgenic mice

This study identifies and validates SARS-CoV-2 CD8+ T cell epitopes, demonstrates their cross-presentation, and shows the efficacy of peptide vaccines in transgenic mice.

SongExplorer: A deep learning workflow for discovery and segmentation of animal acoustic communication signals

SongExplorer uses deep learning to discover, annotate, and segment animal acoustic signals with higher accuracy than existing methods and comparable to human experts.

The SARS-CoV-2 replication-transcription complex is a priority target for broad-spectrum pan-coronavirus drugs

The paper identifies two highly conserved druggable sites in the SARS-CoV-2 replication-transcription complex as potential targets for broad-spectrum antiviral drugs.