multiome

Deep brain stimulation device-specific artefacts in MEG recordings

This study compares DBS artefacts in MEG recordings using different DBS devices and cleaning methods, finding device-specific differences and potential spectral artefacts after cleaning.

Diffusion kurtosis MRI tracks gray matter myelin content in the primate cerebral cortex

This study shows that diffusion kurtosis MRI (MK) strongly correlates with myelin content in the primate cerebral cortex, offering a non-invasive method to assess gray matter myelination.

Integration of Multi-omics Data for the Classification of Glioma Types and Identification of Novel Biomarkers

This study integrates multi-omics data from TCGA to classify glioma types and identify novel biomarkers using DIABLO, finding key pathways and genes associated with glioblastoma and lower-grade gliomas.

Approximation of bone mineral density and subcutaneous adiposity using T1-weighted images of the human head

The paper proposes methods to approximate bone mineral density and subcutaneous adiposity from T1-weighted head MRI images and validates their reliability and correlation with DXA and MRI measurements.

scTIE: data integration and inference of gene regulation using single-cell temporal multimodal data

scTIE integrates temporal multimodal data and infers gene regulatory relationships predictive of cellular state changes, outperforming existing methods in data integration and biological signal preservation.

Age-related fornix decline predicts conservative response strategy-based slowing in perceptual decision-making

This study links age-related decline in fornix fractional anisotropy to slower perceptual decision-making in older adults using a diffusion drift model and neuroimaging data.

The ribosomal protein L22 binds the MDM4 pre-mRNA and promotes exon skipping to activate p53 upon nucleolar stress

Synthesis and Assembly of a New-generation Bifunctional Lipid Nanoparticle for Selective Delivery of mRNA to Antigen Presenting Cells

This paper develops a new mRNA-BLNP3 nanoparticle that selectively delivers mRNA to antigen-presenting cells, showing improved immune responses and reduced liver accumulation compared to previous versions.

An integrated Bayesian framework for multi-omics prediction and classification

The paper introduces a Bayesian ensemble method for multi-omics prediction and classification, showing improved performance and uncertainty quantification across four datasets.

Nerve Growth Factor Receptor Limits Inflammation to Promote Remodeling and Repair of Osteoarthritic Joints

This study identifies NGFR's role in limiting inflammation to promote joint remodeling and repair in osteoarthritis by modulating NF-κB and BMP-SMAD1 signaling.

A unified data infrastructure to support large-scale rare disease research

The paper describes a unified data infrastructure for rare disease research, enabling collaborative analysis of multi-omics data across institutions.

Nanotopography boosts cellular uptake by inducing macropinocytosis

This study shows that nanoporous surfaces enhance cellular uptake of genetic material and other molecules by inducing macropinocytosis, with optimal pore size of 400 nm.

eIF4E1b is a non-canonical eIF4E required for maternal mRNA dormancy

This study identifies eIF4E1b as a key factor in maternal mRNA dormancy by maintaining short polyA tails and repressing translation until needed in zebrafish embryos.

Denoising Diffusion MRI: Considerations and implications for analysis

This paper evaluates dMRI denoising methods by defining performance criteria and comparing patch-based algorithms in complex and magnitude domains.

Influence of plant defense signaling and innate insect metabolic differences to the overall performance of fall armyworm (Spodoptera frugiperda) corn and rice strains on maize as a host

ERK3 Is Involved in Regulating Cardiac Fibroblast Function

This study shows ERK3 regulates cardiac fibroblast function by affecting collagen production and motility in response to TGF-β and TAC.

Multi-omics framework to reveal the molecular determinants of fermentation performance in wine yeast populations

The paper develops a multi-omics framework to identify molecular factors influencing fermentation performance in wine yeast communities, finding that yeast dominance drives metabolite profiles and transcriptomic activity.

Preclinical evaluation of RQ3013, a broad-spectrum mRNA vaccine against SARS-CoV-2 variants

This paper evaluates RQ3013, an mRNA vaccine against SARS-CoV-2 variants, showing robust immune responses and protection in animal models.

Molecular cartography uncovers evolutionary and microenvironmental dynamics in sporadic colorectal tumors

This study maps tumor evolution and microenvironment dynamics in colorectal cancer using spatial multi-omic data, identifying key genes associated with immune exclusion and prognosis.

Multimodal generation of astrocyte by integrating single-cell multi-omics data via deep learning

The paper introduces ACGDC, a deep learning model that generates synthetic single-cell multi-omics samples to aid in brain disease research.

Exploring the Brain Characteristics of Structure-informed Functional Connectivity through Graph Attention Network

This study uses graph attention networks on MRI data to analyze functional connectivity differences between brain gyri, sulci, and subcortical regions, finding task-specific connection importance.

CTNS mRNA as a potential treatment for nephropathic cystinosis

This paper demonstrates that synthetic CTNS mRNA therapy can restore cystinosin function and reduce cystine accumulation in kidney cells and zebrafish models of cystinosis.

Peak-agnostic high-resolution cis-regulatory circuitry mapping using single cell multiome data

The paper introduces CREMA, a framework for mapping cis-regulatory circuits using single-cell multiome data without peak-calling, and validates it using mouse pituitary data.

Paired single-cell multi-omics data integration with Mowgli

Mowgli integrates paired single-cell multi-omics data using a combination of NMF and OT, improving clustering and interpretability, and is benchmarked against state-of-the-art methods.

MKT1 alleles regulate stress responses through post-transcriptional modulation of Puf3 targets in budding yeast

This study shows MKT1 alleles modulate stress responses by stabilizing Puf3-target mitochondrial genes, with PBP1 and PUF3 playing key roles in this regulation.

Polymer-mediated oligonucleotide delivery enables construction of barcoded 3D cultures for spatial single-cell analysis

The paper introduces a method to create barcoded 3D cell cultures for spatial single-cell analysis using polymer-mediated oligonucleotide delivery and multiplex single-cell RNA sequencing.

Multi-Site Statistical Mapping of Along-Tract Microstructural Abnormalities in Bipolar Disorder with Diffusion MRI Tractometry

This study maps microstructural abnormalities along white matter tracts in bipolar disorder using multisite diffusion MRI tractometry and identifies significant differences in fractional anisotropy between BD patients and controls.

TIPE drives a cancer stem-like phenotype by promoting glycolysis via PKM2/HIF-1alpha axis in melanoma

This study shows TIPE promotes glycolysis and stemness in melanoma by interacting with PKM2 and activating HIF-1α through phosphorylation.

Comparing virtual staining artificial intelligence model performance on same-tissue versus serial-tissue sections based on CD3+ T-cell ground truth

This study compares a virtual staining AI model's performance on same-tissue versus serial-tissue sections using CD3+ T-cell ground truth, finding better performance with same-tissue data.

Turnover of PPP1R15A mRNA encoding GADD34 controls the molecular memory of the cellular integrated stress response

The paper identifies a mechanism by which PPP1R15A mRNA stability regulates GADD34 expression, controlling the cellular integrated stress response's memory and adaptation to stress.