Dementia and Cognitive Impairment Research

Amyloid-Tau PET Fusion Reveals Covarying Network Territories Linked to Disease Stage, Cognition, and APOE4 in Alzheimers Disease

The paper uses PET imaging data to identify spatial patterns of Amyloid and Tau covariance in Alzheimer's disease, showing distinct disease-stage and cognitive associations.

Differential associations of insulin resistance with anterior hippocampal volume in mild cognitive impairment and Alzheimer's disease

This study examines how insulin resistance relates to hippocampal volume and cognitive performance in mild cognitive impairment and Alzheimer's disease.

Metabolic brain network reorganization precedes clinical conversion in Alzheimer's disease

The paper identifies hyperconnected metabolic networks in preclinical Alzheimer's converters using FDG-PET data, showing network reorganization precedes clinical conversion.

Investigating the Causal Relationship between Neuroticism and Alzheimer's Disease Using Mendelian Randomization and the Mediating Role of Modifiable Risk Factors

This study uses Mendelian randomization and mediation analysis to show that neuroticism's link to Alzheimer's disease is mediated by modifiable factors like depression, hypertension, and alcohol consumption, rather than being causal.

Elucidating the neuropathological and molecular heterogeneity of amyloid-beta and tau in Alzheimer's disease through machine learning and transcriptomic integration

This study uses machine learning and transcriptomic integration to identify brain network and molecular signatures associated with amyloid-beta and tau in Alzheimer's disease.

Machine learning identifies routine blood tests as accurate predictive measures of pollution-dependent poor cognitive function

This study uses machine learning to identify routine blood tests as predictive markers of pollution-related poor cognitive function in a cohort without neurological disease.

Evaluation of harmonization methods to mitigate assay and cohort effects in plasma p-tau217

This study evaluates harmonization methods to reduce assay and cohort effects in plasma p-tau217 measurements across two cohorts, finding that quantile mapping is most effective.

Machine-learning MRI stratification of genetic frontotemporal dementia for clinical trial enrichment

This paper uses machine learning to stratify genetic frontotemporal dementia patients into subtypes and provides progression scores that improve trial enrichment efficiency.

Cortical thinning in temporal pole, a core region in Alzheimer's disease, in non-demented, middle-aged APOE-e4 and PICALM-AA/AG carriers

This study examines cortical thickness in non-demented middle-aged individuals carrying AD risk alleles APOE-ε4 and PICALM-AA/AG, finding thinner cortex in the right temporal pole compared to non-carriers.

Interpretable Local-to-Global Estimation of Brain Aging Speed From Morphological Changes Using Longitudinal Structural MRI Data

This paper estimates brain aging speed from longitudinal MRI data using deformation fields, providing local and global predictions with improved accuracy and interpretability.

Episodic memory ERPs reflect preclinical Alzheimers disease progression

The paper examines ERP changes in preclinical Alzheimer's disease, finding reduced accuracy and ERP amplitudes in progressors compared to stable and control groups.

A spatially-specific pattern of cortical thickness in frontal lobe predisposes to faster future amyloid accumulation in individuals with subjective cognitive decline

The paper identifies a frontal lobe cortical thickness pattern in amyloid-negative individuals that predicts faster amyloid accumulation over five years.

Exploration of the molecular origins of sex-specific and temporal comorbidity patterns in dementia: insights from the Austrian claims data

This study identifies 51 risk factors for dementia using Austrian hospital claims data, highlighting endocrine/metabolic disorders and vitamin D deficiency as key contributors.

No effects of APOE ε4 on spatial navigation and broader cognition in young adults genetically at risk for Alzheimer's disease

This study finds no significant cognitive or spatial navigation differences in young APOE ε4 carriers compared to non-carriers using app-based navigation and cognitive tasks.

Disrupted Forward Connectivity in Parieto-temporal Network Impairs Memory Performance in Alzheimer's Disease

The paper examines how disrupted forward connectivity in the parieto-temporal network relates to memory impairment and AD pathology using fMRI and DCM in a longitudinal study.

Biomarker Variability Limits Individualized Amyloid Time Estimation in Alzheimer Disease

This study evaluates how biomarker variability affects individualized amyloid time estimation in Alzheimer's disease, finding that inter-individual variability is the main source of error.

Dopamine Compensates for Amyloid-Induced Default Mode Network Dysfunction to Support Learning

This study shows that dopamine compensates for amyloid-induced dysfunction in the default mode network to support learning in preclinical Alzheimer's disease.

Genetic Associations with Temporal Modeling of Alzheimer's Disease Progression Supports a Novel Paradigm for Disease Risk

This paper uses temporal modeling of Alzheimer's disease progression with metabolomics data to identify novel genetic loci associated with disease speed, independent of traditional case-control associations.

Somatosensory gating dysfunction is masked by cognitive variability in cognitively impaired individuals

The paper investigates somatosensory gating dysfunction in cognitively impaired individuals and finds exaggerated gamma SG and altered oscillatory dynamics after controlling for cognitive variability.

Progressive loss of independence in neuronal representations predicts cognitive decline

The paper shows that reduced independence in neuronal representations predicts cognitive decline in Alzheimer's disease models and humans.

Predicting Alzheimer's disease phenotypes with aging clocks: an exploratory analysis

This study explores proteomic and epigenetic aging clocks as biomarkers for Alzheimer's disease phenotypes, finding proteomic clocks improve explained variance in cognitive and biomarker measures by up to 18%.

Postmortem brain MRI reveals differential associations of subcortical and limbic volumes with cortical thinning and neurodegenerative pathologies

The paper examines subcortical and limbic volume associations with cortical thinning and neurodegenerative pathologies in postmortem brain MRI data from multiple disease groups.

Sex-specific associations between astrocytic reactivity and cognitive decline in unimpaired elderly

The paper finds that higher plasma GFAP levels in women are associated with worse episodic memory and lower Aβ42/40 ratio over time, suggesting sex-specific astrocytic reactivity linked to cognitive decline.

Bridging Language Markers and Pathology: Correlations Between Digital Speech Measures and Surrogate CSF Biomarkers in Alzheimer's Disease

This study links digital speech measures to surrogate CSF biomarkers in Alzheimer's disease, finding correlations between speech complexity and amyloid-beta, tau, and phosphorylated tau levels.

Neuroticism is linked to cognitive decline and increased risk of Alzheimer's disease through dysregulation of excitatory neurons

The paper identifies two genes, ADRA1B and LY6E-DT, downregulated in excitatory neurons associated with neuroticism and found to partially mediate the risk of Alzheimer's disease.

Altered Hippocampal Structure-Function Coupling and Brain-Cognition Aging Profile in Mild Cognitive Impairment

This study examines hippocampal structure-function coupling and brain-cognition aging in MCI, finding altered connectivity and a decoupled aging profile.

Polygenic risk scores for incident dementia in the Multi-Ethnic Study of Atherosclerosis

The paper evaluates polygenic risk scores for dementia prediction in diverse populations, finding that a model with fewer SNPs outperforms one with more SNPs in multiple ethnic groups.

Characterisation of Posterior Predominant Amyloid PET Binding Across Multiple Cohorts

This paper identifies a posterior predominant amyloid PET binding pattern in multiple cohorts, showing its clinical and biological relevance and suggesting the need for more nuanced analysis methods.

Discrete Cognitive Resolution in Alzheimer's Disease: Cross-Cohort Reanalysis of ADNI and NACC Longitudinal Data

The paper introduces a discrete cognitive resolution model to analyze longitudinal cognitive data from Alzheimer's Disease cohorts, finding it outperforms continuous models in capturing discrete decline structures.

Alzheimer's Disease Selectively Perturbs Age-Sensitive Brain Radiomic Features Across the Disease Continuum

This study identifies age-sensitive radiomic features in Alzheimer's disease that selectively deviate from normal aging patterns, suggesting potential early biomarkers for neurodegeneration.