MicroRNA in disease regulation

LIN28 selectively modulates a subclass of let-7 microRNAs

The paper identifies a GAU motif recognized by LIN28's CSD domain, which enhances let-7 microRNA suppression in Class I precursors, contributing to development and cancer.

xMD-miRNA-seq to generate near in vivo miRNA expression estimates in colon epithelial cells

The paper introduces xMD-miRNA-seq to obtain in vivo miRNA expression from colon epithelial cells using FFPE tissues, showing cell-specific miRNA profiles comparable to other epithelial sources.

Structural basis for terminal loop recognition and processing of pri-miRNA-18a by hnRNP A1

This study reveals how hnRNP A1 binds to the terminal loop of pri-mir-18a, destabilizing stem base-pairing to enhance miRNA processing.

miR-21-5p and miR-30a-5p are identical in human and bovine, have similar isomiR distribution, and cannot be used to identify xenomiR uptake from cow milk

The paper shows miR-21-5p and miR-30a-5p are identical between human and bovine, and their presence in human blood after milk ingestion is likely due to endogenous regulation or technical issues, not xenomiR uptake.

Overexpressed microRNA-141-3p enhance proliferation via targeting PLAG1 in non-diabetic macrosomia

This study identifies miR-141-3p as a key miRNA that promotes placental proliferation and contributes to non-diabetic macrosomia by targeting PLAG1.

Genome-wide post-transcriptional dysregulation by microRNAs in human asthma as revealed by Frac-seq

The paper uses Frac-seq to analyze microRNA effects on gene expression in asthma, identifying six key microRNAs that regulate ~90% of their targets and contribute to disease mechanisms.

miRNAs in platelet-poor blood plasma and purified RNA are highly stable: a confirmatory study

This study confirms the stability of miRNAs in platelet-poor plasma and purified RNA, showing they are less prone to degradation than other RNAs.

Deep sequencing reveals two Jurkat subpopulations with distinct miRNA profiles during camptothecin-induced apoptosis

The paper identifies two Jurkat subpopulations with distinct miRNA profiles during camptothecin-induced apoptosis, showing 6 miRNAs with inverse expression.

SeedVicious: analysis of microRNA target and near-target sites

SeedVicious predicts microRNA target and near-target sites, detects functional variation, and complements existing tools with improved precision.

Polypyrimidine Tract Binding Protein blocks microRNA-124 biogenesis to enforce its neuronal specific expression.

The paper shows PTBP1 inhibits miR-124 biogenesis in mESCs, creating a regulatory loop that reinforces neuronal differentiation.

Isolation and sequencing of AGO-bound RNAs reveals characteristics of mammalian stem-loop processing in vivo

The paper isolates and sequences AGO-bound RNAs to study pre-miRNA processing in human and mouse cells, identifying novel pre-miRNAs and processing characteristics.

Interplay of target site architecture and miRNA abundance determine miRNA activity and specificity

The paper shows that miRNA activity and specificity depend on both target site architecture and miRNA abundance, challenging the binary view of target site functionality.

Alternative miRNAs: Human Sequences Misidentified As Plant miRNAs In Plant Studies And In Human Plasma

The paper shows that plant miRNAs detected in human plasma are likely artifacts, not evidence of cross-kingdom RNAi.

Prediction of potential disease-associated microRNAs using structural perturbation method

This paper introduces a structural perturbation method (SPM) to predict miRNA-disease associations, showing improved accuracy over existing methods in cross-validation and case studies.

miRNAtools: advanced training using the miRNA web of knowledge

The paper introduces miRNAtools, a web repository of miRNA analysis tools and tutorials for advanced training in miRNA functional analysis.

Comparing miRNA structure of mirtrons and non-mirtrons

The paper compares miRNA structures of mirtrons and non-mirtrons in human and mouse to explore their maturation and structural differences.

The plasma miR-122 basal levels respond to circulating catecholamine in rats

This study shows that plasma miR-122 levels in rats are influenced by circulating catecholamines and stress, suggesting a non-hepatic source for miR-122 release.

miRge 2.0: An updated tool to comprehensively analyze microRNA sequencing data

miRge 2.0 improves miRNA analysis with enhanced detection, A-to-I editing analysis, and better alignment, outperforming existing tools on human datasets.

Subtle alteration in microRNA dynamics accounts for differential nature of cellular proliferation

The paper presents a mathematical model of the Myc/E2F/mir-17-92 network to explain how differential cellular proliferation can be influenced by microRNA dynamics in a cell-type specific manner.

Pan-cancer characterisation of microRNA with hallmarks of cancer reveals role of microRNA-mediated downregulation of tumour suppressor genes

The paper investigates miRNA regulation across 15 cancer types, finding complex interactions between miRNA expression and cancer hallmarks, with specific emphasis on the oncomiR-1 cluster and repression of tumour suppressor genes.

miR-106b-responsive gene landscape identifies regulation of Kruppel-like factor family

The paper identifies miR-106b-regulated genes in cholangiocarcinoma cells, revealing repression of KLF family members and their potential role in tumor biology.

Towards the human cellular microRNAome

The paper establishes the landscape of human cell-specific microRNA expression using small RNA-seq data from diverse cell types and tissues, identifying novel microRNA loci and patterns correlated with super-enhancer activity.

A miRNA catalogue and ncRNA annotation of theshort-living fish Nothobranchius furzeri

The paper presents a comprehensive miRNA and ncRNA catalogue for the short-lived fish Nothobranchius furzeri and compares it to other fish species.

Noise control is a primary function of microRNAs and post-transcriptional regulation

The paper shows microRNAs primarily control expression noise rather than repress protein levels, and this noise control is widespread across species.

Microprocessor dynamics shows co- and post-transcriptional processingof pri-miRNAs

The paper develops a method to study pri-miRNA processing kinetics in vivo and shows co- and post-transcriptional processing occurs with varying speeds.

The presence or absence alone of miRNA isoforms (isomiRs) successfully discriminate amongst the 32 TCGA cancer types

The paper shows that binary isomiR profiles can accurately classify 32 TCGA cancer types with high sensitivity and low false discovery rate.

Functional transcriptomics in diverse intestinal epithelial cell types reveals robust gut microbial sensitivity of microRNAs in intestinal stem cells

The paper shows microbiota regulate miRNA expression in intestinal stem cells more than other cell types, with miR-375 suppression linked to increased stem cell proliferation.